INT129343

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.03
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rasa1) plasma membrane (Rasa1) embryo development (Rasa1)
cytoplasm (Rasa1)
Anatomy Link Frequency
brain 1
Rasa1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 51 97.60 Very High Very High Very High
Pain 2 89.48 High High
qutenza 2 88.48 High High
Thalamus 9 87.68 High High
Action potential 2 64.08 Quite High
ischemia 8 50.00 Quite Low
Nerve growth factor 1 41.68 Quite Low
Hippocampus 12 15.64 Low Low
Analgesic 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Watson Syndrome 8 100.00 Very High Very High Very High
Injury 1 91.20 High High
Cancer 1 86.76 High High
Stroke 64 79.84 Quite High
Transient Ischemic Attack 1 50.00 Quite Low
Necrosis 1 41.64 Quite Low
Nociception 1 25.00 Low Low
Cv General 4 Under Development 4 5.00 Very Low Very Low Very Low
Brain Hemorrhage 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurofibromin is a guanosine triphosphatase activating protein (GAP) for Ras and accelerates the conversion of active Ras-GTP to inactive Ras-GDP; therefore mutation of the NF1 gene frequently results in an increase in activity of the Ras transduction cascade.
Positive_regulation (results) of GAP associated with watson syndrome
1) Confidence 0.10 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 16093333 Disease Relevance 0.82 Pain Relevance 0.24
In summary, long term monitoring of rodent brain for up to 21 days showed motor recovery well in advance of axonal sprouting measured by GAP-53 increase in the peri-lesional tissue.
Positive_regulation (increase) of GAP-53 in brain
2) Confidence 0.02 Published 2007 Journal The Open Neuroimaging Journal Section Body Doc Link PMC2577937 Disease Relevance 0.21 Pain Relevance 0.13

General Comments

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