INT129358

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Context Info
Confidence 0.66
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 23
Total Number 25
Disease Relevance 29.39
Pain Relevance 2.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (ELOVL1) endoplasmic reticulum (ELOVL1)
Anatomy Link Frequency
lymphocytes 1
skin 1
connective tissue 1
fibroblasts 1
T cells 1
ELOVL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 181 100.00 Very High Very High Very High
spinal inflammation 6 99.76 Very High Very High Very High
Pain 21 99.44 Very High Very High Very High
fibrosis 134 98.52 Very High Very High Very High
ischemia 1 97.28 Very High Very High Very High
Central nervous system 13 93.84 High High
metalloproteinase 62 92.48 High High
Calcium channel 8 92.40 High High
antagonist 10 88.72 High High
Fibrositis 12 87.32 High High
Disease Link Frequency Relevance Heat
Systemic Sclerosis 1594 100.00 Very High Very High Very High
Infection 146 100.00 Very High Very High Very High
Hypersensitivity 4 100.00 Very High Very High Very High
Myositis 1 100.00 Very High Very High Very High
Hypoxia 13 99.84 Very High Very High Very High
Vasculitis 7 99.84 Very High Very High Very High
Syndrome 154 99.76 Very High Very High Very High
Low Back Pain 6 99.76 Very High Very High Very High
Disease 381 99.64 Very High Very High Very High
Pain 11 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The underlying genetic background supporting the full expression of both SSc- and AS-susceptibility alleles and the pertinent literature are discussed.
Gene_expression (expression) of SSc associated with spinal inflammation and systemic sclerosis
1) Confidence 0.66 Published 2005 Journal Scand. J. Rheumatol. Section Abstract Doc Link 16095012 Disease Relevance 0.89 Pain Relevance 0.45
There was a statistically significant association between solvent exposure and SSc (OR 5.8, 95% CI 2.5–13.4).
Gene_expression (exposure) of SSc associated with systemic sclerosis
2) Confidence 0.56 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.96 Pain Relevance 0.04
This paper supports the interpretation that there is a weak association between solvent exposure and SSc among women.
Gene_expression (exposure) of SSc associated with systemic sclerosis
3) Confidence 0.56 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.72 Pain Relevance 0.04
OBJECTIVE: Our study had 3 aims: (1) to evaluate the functioning of the Symptom Burden Index (SBI) in patients with systemic sclerosis (SSc); (2) to determine the amount of burden per problem experienced by patients as well as the number of patients experiencing each measured problem area, and the number of SSc problems per patient; and (3) to characterize the burden profiles of problem area-specific subgroups of patients.
Gene_expression (problems) of SSc associated with systemic sclerosis
4) Confidence 0.49 Published 2010 Journal J. Rheumatol. Section Abstract Doc Link 20516027 Disease Relevance 0.37 Pain Relevance 0
Fifty SSc patients were negative for anti-HEV antibodies (all patients tested), suggesting that hepatitis E is not involved in the pathogenesis of SSc [42].
Neg (negative) Gene_expression (negative) of SSc associated with systemic sclerosis and hepatitis
5) Confidence 0.47 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 2.06 Pain Relevance 0.08
The SSc group was comprised of 37% diffuse SSc, had a mean overall MRSS score of 9.5 ± 1.63, and a mean HAQ-DI score of 1.12 ±0.106 (Table 2).
Gene_expression (group) of SSc associated with systemic sclerosis
6) Confidence 0.40 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.03 Pain Relevance 0
The mean disease duration for the SSc group was 9.75 ± 0.53 years, and the mean age of diagnosis was 50.05 ± 1.64 years old (Table 2).
Gene_expression (group) of SSc associated with systemic sclerosis and disease
7) Confidence 0.40 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.17 Pain Relevance 0
A five-page questionnaire consisting of 23 questions was developed to assess: whether subjects had ever had specific infections; whether they had had any infection or antibiotic exposure 12 months prior to their SSc diagnosis; travel history (and any associated illnesses) outside of North America in the 12 months preceding; vaccine history since 18 years of age; and whether or not they had ever been positive for a TB skin test.
Gene_expression (diagnosis) of SSc in skin associated with mycobacterial infection, systemic sclerosis and infection
8) Confidence 0.40 Published 2007 Journal The Open Rheumatology Journal Section Body Doc Link PMC2581823 Disease Relevance 1.35 Pain Relevance 0.04
No association between prior infections and SSc was observed.
Gene_expression (infections) of SSc associated with systemic sclerosis and infection
9) Confidence 0.40 Published 2007 Journal The Open Rheumatology Journal Section Abstract Doc Link PMC2581823 Disease Relevance 2.42 Pain Relevance 0.25
Correlates of 6MWD differ between SSc subgroups and IPF; therefore, the 6MWT distance is not always reflective of the same physiological process. 6MWT interpretation should include consideration of vascular, pulmonary, and musculoskeletal exercise limitations.


Gene_expression (subgroups) of SSc
10) Confidence 0.26 Published 2009 Journal J. Rheumatol. Section Body Doc Link 19208563 Disease Relevance 0 Pain Relevance 0
The present study estimated prevalence, severity, and associations between SSc clinical variables and pain in all patients with SSc and in limited cutaneous (lcSSc) and diffuse cutaneous (dcSSc) subsets.
Gene_expression (with) of SSc associated with pain and systemic sclerosis
11) Confidence 0.24 Published 2010 Journal Arthritis Care Res (Hoboken) Section Abstract Doc Link 20391488 Disease Relevance 0.73 Pain Relevance 0.27
Receiver-operating characteristic curves for the diagnosis of SSc in subjects with RP were plotted for the primary RP and SSc patients.
Gene_expression (diagnosis) of SSc associated with systemic sclerosis
12) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257434 Disease Relevance 0.50 Pain Relevance 0
In this study, we chose to include patients fulfilling the American College of Rheumatology criteria with no evidence of overlap syndrome, in order to study definite SSc cases rather than overlap or undifferentiated connective tissue disease.
Gene_expression (cases) of SSc in connective tissue associated with syndrome, disease and systemic sclerosis
13) Confidence 0.14 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257434 Disease Relevance 1.23 Pain Relevance 0.07
In terms of clinical features, this subgroup was fully representative of the whole SSc group of patients (n = 25 with limited and n = 4 with diffuse disease).
Gene_expression (group) of SSc associated with disease and systemic sclerosis
14) Confidence 0.06 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 1.15 Pain Relevance 0
In SSc different types of antibodies are produced, including anti-centromere and anti-topoisomerase antibodies [3].
Gene_expression (produced) of SSc associated with systemic sclerosis
15) Confidence 0.06 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2276219 Disease Relevance 0.76 Pain Relevance 0.07
1, examined change in mRss over 6 months in patients with diffuse, progressive SSc in its earliest possible stage, who had a median disease duration at baseline of just 6.4 months [14].
Gene_expression (progressive) of SSc associated with disease and systemic sclerosis
16) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2072887 Disease Relevance 0.82 Pain Relevance 0.06
Of the 31 patients in this group, only two started out as ACA+/SS to which a diagnosis of SSc was added, in both cases after one year of follow up.
Gene_expression (diagnosis) of SSc associated with syndrome and systemic sclerosis
17) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888196 Disease Relevance 2.44 Pain Relevance 0
There is evidence that endotelin-1 (ET-1) is a key mediator in regulation of vascular tone and its enhanced production in SSc is believed to lead to vasoconstriction, vessel remodelling, local ischemia and ulcers of fingertips.
Gene_expression (production) of SSc associated with cv general 4 under development, ischemia, ulcers, increased venous pressure under development and systemic sclerosis
18) Confidence 0.04 Published 2007 Journal Reumatismo Section Abstract Doc Link 17603693 Disease Relevance 1.76 Pain Relevance 0.27
During acquisition, lymphocytes were gated according to CD45-PerCP staining and SSC properties and subsequent analysis was done using their FSC versus SSC properties (Figure 1A).
Gene_expression (staining) of SSC in lymphocytes associated with hypersensitivity
19) Confidence 0.03 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2438478 Disease Relevance 0.62 Pain Relevance 0.17
The clinical and physiologic expressions of SSc on sexual function are one such example.
Gene_expression (expressions) of SSc associated with systemic sclerosis
20) Confidence 0.01 Published 2010 Journal International Journal of Rheumatology Section Body Doc Link PMC2958492 Disease Relevance 1.71 Pain Relevance 0.12

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