INT129360

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.49
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn11a) plasma membrane (Scn11a) transmembrane transport (Scn11a)
Anatomy Link Frequency
neuronal 2
sensory neurons 2
pineal gland 2
Scn11a (Mus musculus)
Pain Link Frequency Relevance Heat
nav1.3 2 99.56 Very High Very High Very High
Morphine 6 99.48 Very High Very High Very High
Opioid 1 76.96 Quite High
fibrosis 22 76.04 Quite High
opioid receptor 1 75.84 Quite High
tetrodotoxin 5 75.00 Quite High
sodium channel 1 75.00 Quite High
dorsal root ganglion 1 54.72 Quite High
Action potential 6 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 93.12 High High
Fibrosis 19 76.04 Quite High
Targeted Disruption 4 52.48 Quite High
Disease 4 50.00 Quite Low
Arrhythmias 2 Under Development 27 44.60 Quite Low
Nociception 1 39.72 Quite Low
Heart Arrhythmia 16 8.48 Low Low
Aging 10 5.00 Very Low Very Low Very Low
Heart Rate Under Development 5 5.00 Very Low Very Low Very Low
Cardiovascular Disorder Under Development 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data also indicate that unidentified factors may be required for the efficient functional expression of Na(V)1.8 with a biophysical phenotype identical to that found in sensory neurons.
Spec (may) Positive_regulation (required) of Gene_expression (expression) of Na in sensory neurons
1) Confidence 0.10 Published 2008 Journal J. Neurophysiol. Section Abstract Doc Link 18272876 Disease Relevance 0.30 Pain Relevance 0.20
Overexpression of the mRNA of neuronal Na+ channel, Nav1.3, and T-type Ca2+ channel, Cav3.2, may result from a feedback mechanism compensating for the larger conduction deficit of mice with a severe phenotype.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of Na in neuronal associated with nav1.3
2) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824822 Disease Relevance 0.18 Pain Relevance 0.16
The results showed that both acute and chronic morphine treatments significantly increased NAT mRNA expression in rat pineal gland.
Positive_regulation (increased) of Gene_expression (expression) of NAT mRNA in pineal gland associated with morphine
3) Confidence 0.01 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16095816 Disease Relevance 0 Pain Relevance 0.64

General Comments

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