INT129374

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.58
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)
Anatomy Link Frequency
paw 2
NS20Y 2
nerve 1
dorsal horn 1
Oprm1 (Mus musculus)
Pain Link Frequency Relevance Heat
mu opioid receptor 87 100.00 Very High Very High Very High
Dorsal horn neuron 2 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
Eae 4 99.44 Very High Very High Very High
Spinal cord 3 99.20 Very High Very High Very High
potassium channel 1 88.88 High High
Root ganglion neuron 1 59.52 Quite High
opioid receptor 5 50.00 Quite Low
analgesia 2 50.00 Quite Low
Opioid 6 41.68 Quite Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 99.30 Very High Very High Very High
Nervous System Injury 3 97.90 Very High Very High Very High
Repression 14 92.48 High High
Injury 1 75.00 Quite High
Ganglion Cysts 1 59.12 Quite High
Pain 3 39.52 Quite Low
Hypersensitivity 1 25.00 Low Low
Disease 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: At 4 weeks after SGAMOR and SGMOR infection, decreased and increased muOR immunoreactivity was observed in ipsilateral dorsal hind paw skin, lumbar dorsal root ganglion cells, and superficial dorsal horns, respectively, compared with SGZ.
Negative_regulation (decreased) of Regulation (immunoreactivity) of muOR in paw
1) Confidence 0.43 Published 2008 Journal Anesthesiology Section Body Doc Link 18212576 Disease Relevance 0 Pain Relevance 0
The result suggested that this GC box element may mainly act as a repressor in MOR gene regulation and explained why the MOR transcription level is very low in NS20Y cell line.
Negative_regulation (repressor) of Regulation (regulation) of MOR in NS20Y associated with mu opioid receptor
2) Confidence 0.36 Published 2006 Journal Nucleic Acids Research Section Body Doc Link PMC1702488 Disease Relevance 0.09 Pain Relevance 0.49
In both the spared nerve injury (SNI) and spinal nerve ligation (SNL) rat peripheral neuropathic pain models the presynaptic inhibitory effect of the mu opioid receptor (MOR) agonist (DAMGO) on primary afferent-evoked excitatory postsynaptic currents (EPSCs) and miniature EPSCs in superficial dorsal horn neurons is substantially reduced, but only in those spinal cord segments innervated by injured primary afferents.
Negative_regulation (reduced) of in nerve Regulation (effect) of MOR in dorsal horn associated with nervous system injury, eae, neuropathic pain, agonist, mu opioid receptor, dorsal horn neuron and spinal cord
3) Confidence 0.06 Published 2005 Journal Pain Section Abstract Doc Link 16098668 Disease Relevance 0.49 Pain Relevance 0.68

General Comments

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