INT129375

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Context Info
Confidence 0.28
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
nerve 1
dorsal horn 1
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 7 100.00 Very High Very High Very High
Dorsal horn neuron 2 100.00 Very High Very High Very High
agonist 1 100.00 Very High Very High Very High
Eae 4 99.44 Very High Very High Very High
Spinal cord 3 99.20 Very High Very High Very High
potassium channel 1 88.88 High High
Root ganglion neuron 1 59.52 Quite High
Opioid 4 41.68 Quite Low
Spontaneous pain 2 40.48 Quite Low
Neuropathic pain 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 2 99.30 Very High Very High Very High
Nervous System Injury 3 97.90 Very High Very High Very High
Injury 1 75.00 Quite High
Ganglion Cysts 1 59.12 Quite High
Pain 2 39.52 Quite Low
Hypersensitivity 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In both the spared nerve injury (SNI) and spinal nerve ligation (SNL) rat peripheral neuropathic pain models the presynaptic inhibitory effect of the mu opioid receptor (MOR) agonist (DAMGO) on primary afferent-evoked excitatory postsynaptic currents (EPSCs) and miniature EPSCs in superficial dorsal horn neurons is substantially reduced, but only in those spinal cord segments innervated by injured primary afferents.
Negative_regulation (reduced) of in nerve Regulation (effect) of mu opioid receptor in dorsal horn associated with nervous system injury, eae, neuropathic pain, agonist, mu opioid receptor, dorsal horn neuron and spinal cord
1) Confidence 0.28 Published 2005 Journal Pain Section Abstract Doc Link 16098668 Disease Relevance 0.49 Pain Relevance 0.68

General Comments

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