INT129398

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 7.11
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD1) peroxisome (SOD1) protein complex (SOD1)
cytoplasm (SOD1) cytosol (SOD1) extracellular space (SOD1)
Anatomy Link Frequency
liver 5
heart 3
joint 2
muscles 2
HL-60 2
SOD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 9 97.80 Very High Very High Very High
Osteoarthritis 33 97.60 Very High Very High Very High
agonist 9 96.88 Very High Very High Very High
Pain 20 86.16 High High
Inflammation 78 81.84 Quite High
Hippocampus 12 50.00 Quite Low
cINOD 10 46.08 Quite Low
COX2 4 25.00 Low Low
anesthesia 10 15.56 Low Low
Arthritis 1 10.00 Low Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 8 99.76 Very High Very High Very High
Poisoning 11 99.06 Very High Very High Very High
Osteoarthritis 32 97.60 Very High Very High Very High
Stress 169 97.44 Very High Very High Very High
Disease 131 91.52 High High
Leukemia 4 90.64 High High
Decapitation 1 89.08 High High
Motor Neuron Diseases 36 88.72 High High
Cancer 66 87.68 High High
Hepatotoxicity 17 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As presented in Table 3, SOD1 variants' loss of net charge correlates with increased patient survival, while gain of hydrophobicity, loss of ?
Negative_regulation (loss) of Gene_expression (variants) of SOD1
1) Confidence 0.43 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2486295 Disease Relevance 0.32 Pain Relevance 0
The expression of the mRNAs for MnSOD and Cu/ZnSOD in HL-60 cells, as assessed by RT-PCR, was significantly inhibited by treatment with 1 mM EUG for 1 hour.
Negative_regulation (inhibited) of Gene_expression (expression) of SOD in HL-60
2) Confidence 0.41 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16101137 Disease Relevance 0.26 Pain Relevance 0
Furthermore, inhibition of SOD mRNAs expression by EUG was strongly potentiated by the addition of 5 mM N-acetyl cysteine (NAC) or glutathione (GSH), whereas NAC or GSH alone did not affect the expression of SOD mRNAs.
Negative_regulation (inhibition) of Gene_expression (expression) of SOD
3) Confidence 0.41 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16101137 Disease Relevance 0.25 Pain Relevance 0
The expression of MnSOD and, less strongly, Cu/ZnSOD activity, as assessed by acrylamide gel electrophoresis, was inhibited by EUG, suggesting mitochondrial dysfunction.
Negative_regulation (inhibited) of Gene_expression (expression) of SOD associated with parkinson's disease
4) Confidence 0.41 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16101137 Disease Relevance 0.26 Pain Relevance 0
The cytotoxicity of EUG was significantly enhanced by high concentrations of NAC or GSH, which may be attributed to the inhibition of SOD mRNAs expression by the synergistic action of EUG and GSH or NAC.
Negative_regulation (inhibition) of Gene_expression (expression) of SOD
5) Confidence 0.41 Published 2005 Journal Anticancer Res. Section Abstract Doc Link 16101137 Disease Relevance 0.28 Pain Relevance 0
Measurement of SOD1 activity
Negative_regulation (Measurement) of Gene_expression (activity) of SOD1
6) Confidence 0.37 Published 2004 Journal Proteome Sci Section Body Doc Link PMC446209 Disease Relevance 0.50 Pain Relevance 0.09
A significant main effect for time was observed in serum SOD levels, indicating an increase following all exercise performance measurements on day 0 (T2) and day 14 (T3).
Negative_regulation (observed) of Gene_expression (levels) of SOD
7) Confidence 0.29 Published 2008 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2315638 Disease Relevance 0.30 Pain Relevance 0
Our results showed a significant decrease of GSH levels, AA levels and SOD activity and an increase of MDA and GSSG levels after APAP administration.
Negative_regulation (decrease) of Gene_expression (levels) of SOD associated with paracetamol
8) Confidence 0.28 Published 2007 Journal Phytomedicine Section Abstract Doc Link 16638633 Disease Relevance 0.27 Pain Relevance 0.56
Decreases in the levels or activities of anti-oxidant enzymes, such as SOD and GPx, and of both water soluble and lipophilic antioxidant micronutrients such as vitamins A, C and E, and ?
Negative_regulation (Decreases) of Gene_expression (levels) of SOD
9) Confidence 0.23 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1420275 Disease Relevance 0.68 Pain Relevance 0
Treatment with deferoxamine moderately restored (~20%) the SOD levels in both the exposed groups; while resveratrol significantly reversed the depleted SOD levels in the CuO/silica and MCP230 treated cells.


Negative_regulation (reversed) of Gene_expression (levels) of SOD
10) Confidence 0.18 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0 Pain Relevance 0
Treatment with deferoxamine moderately restored (~20%) the SOD levels in both the exposed groups; while resveratrol significantly reversed the depleted SOD levels in the CuO/silica and MCP230 treated cells.


Negative_regulation (depleted) of Gene_expression (levels) of SOD
11) Confidence 0.18 Published 2009 Journal Part Fibre Toxicol Section Body Doc Link PMC2676242 Disease Relevance 0 Pain Relevance 0
Recent evidence has suggested a role for oxidative stress in the pathogenesis of OA whereby an excess of reactive oxygen species arising from an imbalance in the antioxidant status of the joint (such as reduced levels of SOD) may result in cartilage degradation and joint remodeling [13].
Negative_regulation (reduced) of Gene_expression (levels) of SOD in joint associated with stress and osteoarthritis
12) Confidence 0.16 Published 2008 Journal Nutr J Section Body Doc Link PMC2265739 Disease Relevance 0.83 Pain Relevance 0.32
As expected, over-expression of SOD1 decreased basal LC3-II levels (Fig. 5F).


Negative_regulation (decreased) of Gene_expression (over) of SOD1
13) Confidence 0.14 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.15 Pain Relevance 0
We too observed that CCl4 challenge significantly decreased the levels of SOD and catalase in liver and kidney.
Negative_regulation (decreased) of Gene_expression (levels) of SOD in liver
14) Confidence 0.06 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.56 Pain Relevance 0
The total cell lysate was prepared using 50 mM phosphate buffer (pH 7.8), which was used to measure SOD expression/activity and catalase expression levels.
Negative_regulation (measure) of Gene_expression (expression) of SOD
15) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.43 Pain Relevance 0
CCl4 challenge significantly decreased the levels of SOD and catalase in both liver (SOD: control = 25.66 U/mg protein; Catalase: control = 0.32 K/min) and kidneys (SOD: control = 99.22 U/mg protein; Catalase: control = 0.32 K/min).
Negative_regulation (decreased) of Gene_expression (levels) of SOD in liver
16) Confidence 0.04 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.08 Pain Relevance 0
Recently, Szymonik-Lesiuk et al [2] have shown that CCl4 intoxication can lead to alteration in gene expression and depletion of SOD and catalase levels in kidney and heart.
Negative_regulation (depletion) of Gene_expression (levels) of SOD in heart associated with poisoning
17) Confidence 0.04 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.50 Pain Relevance 0
The loss of contractile function that was observed after exposure to oxypurinol in electrically stimulated EDL and soleus muscles or PEG-SOD in EDL muscles suggests that these agents alter processes within the intact muscle cell.
Negative_regulation (loss) of Gene_expression (muscles) of SOD in muscles
18) Confidence 0.04 Published 2010 Journal American Journal of Physiology - Regulatory, Integrative and Comparative Physiology Section Body Doc Link PMC2806206 Disease Relevance 0.07 Pain Relevance 0
Assay of SOD activity
Negative_regulation (Assay) of Gene_expression (activity) of SOD
19) Confidence 0.03 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994390 Disease Relevance 0 Pain Relevance 0
SOD and CAT may not be direct transcriptional targets of SXR and the mechanism of SXR-mediated downregulation of SOD and CAT activities remains to be determined.
Negative_regulation (mechanism) of Gene_expression (targets) of SOD
20) Confidence 0.02 Published 2009 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2646121 Disease Relevance 0.30 Pain Relevance 0.05

General Comments

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