INT12942

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Context Info
Confidence 0.35
First Reported 1991
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.29
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ITGAL) cell adhesion (ITGAL) plasma membrane (ITGAL)
Anatomy Link Frequency
mammary gland 1
blood 1
leukocyte 1
PPH 1
neutrophils 1
ITGAL (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 10 100.00 Very High Very High Very High
Opioid 7 100.00 Very High Very High Very High
adenocard 1 97.92 Very High Very High Very High
imagery 17 84.08 Quite High
Inflammation 16 80.24 Quite High
psoriasis 3 76.96 Quite High
Potency 2 64.72 Quite High
headache 1 55.44 Quite High
Somatostatin 1 52.52 Quite High
cytokine 23 41.88 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 32 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 92 96.92 Very High Very High Very High
Viral Infection 5 93.20 High High
Cancer 139 90.40 High High
INFLAMMATION 22 80.24 Quite High
Multiple Organ Failure 6 80.00 Quite High
Respiratory Distress 1 79.64 Quite High
Cytomegalovirus Infection 6 76.96 Quite High
Psoriasis 3 76.96 Quite High
Infection 31 74.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the expression of other adhesion molecules by neutrophils was unaffected (CD11a, CD31, CD44) or slightly increased (CD11b).
Neg (unaffected) Regulation (unaffected) of CD11a in neutrophils
1) Confidence 0.35 Published 1996 Journal J. Rheumatol. Section Body Doc Link 8730134 Disease Relevance 0.12 Pain Relevance 0
To assess the effect of opioid peptides on CD11a, CD11b, CD18 and CD16 molecule expression the whole blood samples were incubated with different concentrations of the opioids, then the white cells were labelled with respective PE-conjugated MoAb and evaluated by flow cytometry.
Regulation (effect) of CD11a in blood associated with opioid
2) Confidence 0.32 Published 1999 Journal Immunol. Lett. Section Abstract Doc Link 10232386 Disease Relevance 0.15 Pain Relevance 0.91
Efalizumab is a humanized, monoclonal antibody, which targets CD11a, one of the subunits of leukocyte function-associated antigen-1.
Regulation (targets) of CD11a in leukocyte
3) Confidence 0.26 Published 2004 Journal Dermatol Ther Section Abstract Doc Link 15379774 Disease Relevance 0.29 Pain Relevance 0.17
The biological effects of statins on cholesterol metabolism, Rho GTPases activity, LFA-1/ICAM-1 function and CCR5/RANTES expression can disrupt several steps of the HIV-1 life cycle, and target cell membrane interaction.
Regulation (effects) of LFA-1 associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.10 Published 2009 Journal Trials Section Body Doc Link PMC2705367 Disease Relevance 0.86 Pain Relevance 0.03
To our knowledge the effect of

CVVHD on the important adhesion molecules CD11a, CD11b, CD18 and CD44 has not been investigated before.

Spec (investigated) Regulation (effect) of CD11a associated with adhesions
5) Confidence 0.08 Published 1999 Journal Crit Care Section Body Doc Link PMC29032 Disease Relevance 1.07 Pain Relevance 0
Regulation of the human enkephalin promoter by two isoforms of the catalytic subunit of cyclic adenosine 3',5'-monophosphate-dependent protein kinase.
Regulation (Regulation) of promoter associated with adenocard and enkephalin
6) Confidence 0.03 Published 1991 Journal Mol. Endocrinol. Section Title Doc Link 1658633 Disease Relevance 0.08 Pain Relevance 0.42
Expression of transgenes or gene ablation specific to the mammary gland is usually achieved by placing the transgene or Cre recombinase under the control of a milk gene promoter or the MMTV promoter [47].
Regulation (control) of milk gene promoter in mammary gland
7) Confidence 0.01 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2397525 Disease Relevance 0.29 Pain Relevance 0.04
We focused on one MxA positive cell line, the PaCa44, and used the ISG15 gene, directly dependent on ISRE promoter, as a marker of downstream silencing (Figure 6B).
Regulation (dependent) of ISRE promoter
8) Confidence 0.01 Published 2010 Journal J Transl Med Section Body Doc Link PMC2845551 Disease Relevance 0.44 Pain Relevance 0
PPH were transfected with simian virus 40 (SV40) T antigen under the control of the SV40 early promoter.
Regulation (control) of early promoter in PPH
9) Confidence 0.00 Published 1999 Journal Cell Transplant Section Abstract Doc Link 10442735 Disease Relevance 0 Pain Relevance 0

General Comments

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