INT129423

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Context Info
Confidence 0.11
First Reported 2003
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.62
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Impdh1) RNA binding (Impdh1) nucleus (Impdh1)
DNA binding (Impdh1) cytoplasm (Impdh1)
Impdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 1 72.68 Quite High
dopamine receptor 1 72.24 Quite High
Inflammation 2 70.16 Quite High
corticosteroid 1 49.84 Quite Low
Analgesic 1 25.00 Low Low
anesthesia 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 1 93.60 High High
Acute Myocarditis 41 92.56 High High
INFLAMMATION 2 70.16 Quite High
Disorder Of Lipid Metabolism 1 69.60 Quite High
Disease 2 46.24 Quite Low
Toxicity 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Infection 4 5.00 Very Low Very Low Very Low
Heart Disease 2 5.00 Very Low Very Low Very Low
Dilated Cardiomyopathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MPA, which is a potent inhibitor of IMP-dehydrogenase depletes intracellular GTP pools thereby inhibiting viral RNA synthesis and as a consequence viral replication.
Negative_regulation (inhibitor) of IMP-dehydrogenase
1) Confidence 0.11 Published 2003 Journal BMC Microbiol Section Body Doc Link PMC317291 Disease Relevance 0.38 Pain Relevance 0
These boron-containing compounds were shown to inhibit DNA synthesis; such inhibition was caused primarily by reducing de novo purine biosynthesis via inhibition of PRPP amidotransferase, IMP dehydrogenase and dihydrofolate reductase activities.
Negative_regulation (inhibition) of IMP dehydrogenase
2) Confidence 0.03 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16101500 Disease Relevance 0.23 Pain Relevance 0.11

General Comments

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