INT129425

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 17.15
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ldlr) transport (Ldlr) plasma membrane (Ldlr)
lipid metabolic process (Ldlr) lysosome (Ldlr)
Anatomy Link Frequency
plasma 3
fat pads 2
liver 1
fat 1
adipose tissue 1
Ldlr (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 11 97.44 Very High Very High Very High
noradrenaline 42 89.04 High High
Catecholamine 36 85.68 High High
alcohol 3 85.44 High High
tolerance 27 75.28 Quite High
behavioral therapy 14 74.44 Quite High
agonist 49 74.00 Quite High
Inflammation 65 68.32 Quite High
antagonist 14 59.12 Quite High
dopamine receptor 1 58.68 Quite High
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 270 100.00 Very High Very High Very High
Stress 30 100.00 Very High Very High Very High
Obesity 476 99.88 Very High Very High Very High
Hyperlipoproteinemia Type Ii 293 99.78 Very High Very High Very High
Body Weight 193 99.24 Very High Very High Very High
Atherosclerosis 232 99.16 Very High Very High Very High
Hyperlipidemia 137 99.06 Very High Very High Very High
Metabolic Syndrome 43 98.88 Very High Very High Very High
Cv Unclassified Under Development 25 97.44 Very High Very High Very High
Hypertriglyceridemia 25 96.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ApoB100-LDL mediated inhibition of lipolysis was abolished in fat pads of mice deficient in the LDL receptor (Ldlr?
Negative_regulation (deficient) of LDL receptor in fat pads
1) Confidence 0.42 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2582480 Disease Relevance 0.76 Pain Relevance 0.08
Our findings suggest that decreased LDL concentrations in the microcirculation of adipose tissue cause a reciprocal activation of lipolysis in white adipose tissue when apoB100-LDL levels are decreased.
Negative_regulation (decreased) of apoB100-LDL in adipose tissue associated with obesity
2) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2582480 Disease Relevance 0.86 Pain Relevance 0.11
Male mice deficient in both mPGES-1 and LDLR (mPGES-1(-/-) LDLR(-/-)) and littermate LDLR(-/-) mice were initiated on a high-fat diet at 6 months of age, followed 1 week later by continuous infusion of angiotensin II (1 microg/kg per minute) for an additional 4 weeks.
Negative_regulation (deficient) of LDLR in fat
3) Confidence 0.40 Published 2008 Journal Circulation Section Body Doc Link 18285567 Disease Relevance 0.36 Pain Relevance 0
ApoB100-LDL mediated inhibition of lipolysis was abolished in fat pads of mice deficient in the LDL receptor (Ldlr?
Negative_regulation (deficient) of Ldlr in fat pads
4) Confidence 0.37 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2582480 Disease Relevance 0.77 Pain Relevance 0.08
The clinical phenotype of the autosomal recessive form is similar to that of the classic homozygous FH caused by defects in the LDLR gene, but it is generally less severe and more responsive to lipid-lowering therapy (reviewed in [10]).
Negative_regulation (defects) of LDLR gene associated with hyperlipoproteinemia type ii
5) Confidence 0.34 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.92 Pain Relevance 0
This article reviews the progress made in the 18 years since the first clinical trial for gene therapy of FH, with emphasis on the development, design, performance and limitations of viral based gene transfer vectors used in studies to ameliorate the effects of LDLR deficiency.



Negative_regulation (deficiency) of LDLR associated with hyperlipoproteinemia type ii
6) Confidence 0.34 Published 2010 Journal Int Arch Med Section Abstract Doc Link PMC3016243 Disease Relevance 0.41 Pain Relevance 0
In contrast to using a cDNA expression cassette, the use of a complete genomic DNA locus to deliver an intact transgene with its native promoter, exons, all intervening introns, and regulatory regions with flanking non-coding genomic DNA sequences may allow regulated complementation of LDLR deficiency in the liver of hypercholesterolaemic animals.
Negative_regulation (deficiency) of LDLR in liver
7) Confidence 0.34 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.35 Pain Relevance 0
The loss of LDLR increases susceptibility to diet-induced obesity and hypertriglyceridemia.
Negative_regulation (loss) of LDLR associated with obesity and hyperlipidemia
8) Confidence 0.32 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943125 Disease Relevance 1.54 Pain Relevance 0
Berberine could increase the transcriptional activity of LDLR promoter and it involved the JNK pathway, reducing serum LDL [11].
Negative_regulation (reducing) of serum LDL
9) Confidence 0.28 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.35 Pain Relevance 0
While in humans the deficiency of LDL receptors (LDLR) leads to a dramatic phenotype of pronounced hypercholesterolemia with catastrophic clinical consequences, mice lacking the LDL receptor (LDLR-/-) display only a modest hypercholesterolemia when fed on a normal diet [28].
Negative_regulation (deficiency) of LDLR associated with hyperlipidemia
10) Confidence 0.25 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 1.02 Pain Relevance 0.03
While in humans the deficiency of LDL receptors (LDLR) leads to a dramatic phenotype of pronounced hypercholesterolemia with catastrophic clinical consequences, mice lacking the LDL receptor (LDLR-/-) display only a modest hypercholesterolemia when fed on a normal diet [28].
Negative_regulation (lacking) of LDL receptor associated with hyperlipidemia
11) Confidence 0.25 Published 2010 Journal The Open Neurology Journal Section Body Doc Link PMC2928914 Disease Relevance 1.04 Pain Relevance 0.09
Serum lipid levels such as total cholesterol level, LDL-cholesterol level and triglyceride level were decreased but not significantly.
Negative_regulation (decreased) of LDL-cholesterol associated with disorder of lipid metabolism
12) Confidence 0.23 Published 2009 Journal Nutrition Research and Practice Section Abstract Doc Link PMC2809238 Disease Relevance 0.49 Pain Relevance 0.07
Although we found no evidence that berberine can reduce serum LDL, the upregulation of MAPK is a possible factor in the berberine lipid-regulating mechanism.
Negative_regulation (reduce) of serum LDL
13) Confidence 0.21 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.31 Pain Relevance 0
While in this study, we found no evidence that berberine reduces serum LDL-c.
Negative_regulation (reduces) of serum LDL
14) Confidence 0.18 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952334 Disease Relevance 0.53 Pain Relevance 0.04
In heFH, the presence of one abnormal LDL-R allele is associated with approximately 50% loss of LDL-R activity and two fold increase in plasma levels of LDL-C.
Negative_regulation (loss) of LDL-R in plasma
15) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.75 Pain Relevance 0
In hoFH patients, the presence of two abnormal LDL-R alleles is associated with approximately 100% loss of LDL-R activity and several-fold increases in plasma levels of LDL-C.
Negative_regulation (loss) of LDL-R in plasma
16) Confidence 0.17 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2988620 Disease Relevance 0.77 Pain Relevance 0
The serum TC, LDL-cholesterol and TG were reduced during the 8-week body weight control program but not significantly.


Negative_regulation (reduced) of LDL-cholesterol in body associated with body weight and disorder of lipid metabolism
17) Confidence 0.16 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2809238 Disease Relevance 0.35 Pain Relevance 0
They decreased low-density lipoprotein (LDL) cholesterol while increasing high-density lipoprotein (HDL) cholesterol levels.
Negative_regulation (decreased) of low-density lipoprotein associated with disorder of lipid metabolism
18) Confidence 0.15 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16101500 Disease Relevance 0.23 Pain Relevance 0.09
The antiatherosclerotic effects of sEHI are correlated with elevation in EET levels and associated with reduction of low-density lipoprotein and elevation of high-density lipoprotein cholesterols, as well as attenuation of expression of proinflammatory genes and proteins.
Negative_regulation (reduction) of low-density lipoprotein
19) Confidence 0.05 Published 2010 Journal Curr Atheroscler Rep Section Abstract Doc Link PMC2857794 Disease Relevance 0.74 Pain Relevance 0.03
g bid for an average of 3.5 years demonstrated significant reductions in triglycerides (12%), total cholesterol (5%), low-density lipoprotein (LDL) cholesterol (6%), and increases in high-density lipoprotein (HDL) cholesterol (24%);129 again, these beneficial effects were related to the magnitude of weight loss.
Negative_regulation (reductions) of low-density lipoprotein associated with weight loss and disorder of lipid metabolism
20) Confidence 0.03 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731024 Disease Relevance 0.92 Pain Relevance 0.06

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