INT129429

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Context Info
Confidence 0.41
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.09
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Stat1) nucleus (Stat1) enzyme binding (Stat1)
DNA binding (Stat1) cytoplasm (Stat1)
Stat1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 14 95.44 Very High Very High Very High
Dopamine 1 79.56 Quite High
cytokine 1 77.56 Quite High
Pain 1 77.56 Quite High
Neuropeptide 5 74.80 Quite High
cINOD 2 65.52 Quite High
Spinal cord 17 5.00 Very Low Very Low Very Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 5 95.88 Very High Very High Very High
INFLAMMATION 19 95.44 Very High Very High Very High
Adhesions 2 91.68 High High
Injury 35 78.32 Quite High
Pain 2 77.56 Quite High
Apoptosis 24 73.32 Quite High
Cv Unclassified Under Development 1 67.04 Quite High
Spinal Cord Injury 29 39.32 Quite Low
Death 12 5.00 Very Low Very Low Very Low
Spinal Injuries 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This review focuses the attention on an alternative approach to the development of novel drugs based on inhibition of STAT1 pathway.
Negative_regulation (inhibition) of STAT1
1) Confidence 0.41 Published 2005 Journal Curr. Med. Chem. Section Abstract Doc Link 16101503 Disease Relevance 0.55 Pain Relevance 0.29
While a majority of the genes significantly affected by axotomy were down regulated, 4 genes exhibited significant up-regulation following axotomy, a transcription factor (Stat1), a growth factor receptor component (Frs2), an actin-cytoskeletal related protein (Nrap), and a cell stress and axonal regeneration associated gene (Hspb1) (Figure 1).
Negative_regulation (exhibited) of Stat1 associated with stress
2) Confidence 0.26 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.53 Pain Relevance 0.15

General Comments

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