INT129436

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 1.02
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Hk1) mitochondrion (Hk1) nucleus (Hk1)
carbohydrate metabolic process (Hk1) protein complex (Hk1) kinase activity (Hk1)
Hk1 (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 4 99.84 Very High Very High Very High
Analgesic 6 99.70 Very High Very High Very High
Hyperalgesia 2 97.54 Very High Very High Very High
antagonist 6 95.80 Very High Very High Very High
opioid receptor 4 94.80 High High
Intracerebroventricular 2 86.56 High High
tail-flick 2 85.36 High High
Pain 6 83.08 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 98.86 Very High Very High Very High
Pain 4 83.08 Quite High
Nociception 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The maximal analgesic effect of r/m HK-1 (3 nmol/mouse) could also be reversed by naloxone (i.p., 2 mg/kg).
Negative_regulation (reversed) of HK-1 associated with analgesic and narcan
1) Confidence 0.48 Published 2005 Journal Brain Res. Section Abstract Doc Link 16102736 Disease Relevance 0.45 Pain Relevance 0.74
However, i.c.v. low dose administration of r/m HK-1 (10, 3, 1 pmol/mouse) induced hyperalgesia with a "U" shape curve, which means that the maximal hyperalgesic effect appeared at 3 pmol/mouse, and this effect of r/m HK-1 could also be fully blocked by SR140333.
Negative_regulation (blocked) of HK-1 associated with hyperalgesia
2) Confidence 0.40 Published 2005 Journal Brain Res. Section Abstract Doc Link 16102736 Disease Relevance 0.56 Pain Relevance 0.78

General Comments

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