INT129441

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Context Info
Confidence 0.24
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.29
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (P2rx7) mitochondrion organization (P2rx7) protein complex (P2rx7)
transmembrane transport (P2rx7) cytoplasm (P2rx7) cell death (P2rx7)
Anatomy Link Frequency
brainstem 2
P2rx7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 178 100.00 Very High Very High Very High
medulla 18 100.00 Very High Very High Very High
Glutamate 131 98.80 Very High Very High Very High
Inflammation 50 98.72 Very High Very High Very High
Sciatic nerve 4 97.80 Very High Very High Very High
Potency 127 97.64 Very High Very High Very High
Dopamine 63 97.28 Very High Very High Very High
Pain 45 94.96 High High
excitatory amino acid 16 89.96 High High
rheumatoid arthritis 4 88.56 High High
Disease Link Frequency Relevance Heat
Nervous System Injury 8 99.36 Very High Very High Very High
Disease 2 98.92 Very High Very High Very High
INFLAMMATION 52 98.72 Very High Very High Very High
Peritonitis 8 98.48 Very High Very High Very High
Injury 13 97.84 Very High Very High Very High
Targeted Disruption 28 97.44 Very High Very High Very High
Status Epilepticus 106 96.72 Very High Very High Very High
Retinal Diseases 1 96.48 Very High Very High Very High
Nociception 21 96.44 Very High Very High Very High
Pain 53 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, our experimental schedules were designed to inhibit the function of P2X7 receptor and IL-1?
Regulation (function) of Gene_expression (receptor) of P2X7
1) Confidence 0.24 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2964655 Disease Relevance 0.70 Pain Relevance 0.03
As observed for other classes of P2X7 antagonists, activity to inhibit Ca2+ flux translated into comparable potency to inhibit IL-1?
Regulation (classes) of Gene_expression (antagonists) of P2X7 associated with antagonist and potency
2) Confidence 0.23 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.16 Pain Relevance 0.46
In view of the participation of P2X7 in the release of IL-1?
Regulation (view) of Gene_expression (participation) of P2X7
3) Confidence 0.23 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 1.05 Pain Relevance 0.74
These data were consistent with the mechanistic role of P2X7 receptors in modulating IL-1?
Regulation (role) of Gene_expression (receptors) of P2X7
4) Confidence 0.23 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 1.22 Pain Relevance 0.72
Fig. 6Cyanoguanidine-piperazine P2X7 antagonists

Aryltetrazoles/aryltriazoles

Regulation (aryltriazoles) of Gene_expression (antagonists) of P2X7 associated with antagonist
5) Confidence 0.20 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.34
It can be assumed that these adaptive changes in the P2 receptor expression are aimed to enhance the sensitivity of these receptors to respond to motivation-related stimuli like food.


Regulation (changes) of Gene_expression (expression) of P2 receptor
6) Confidence 0.04 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0.22 Pain Relevance 0.40
However, in this study we found that application of P2 receptor antagonist PPADS in a high concentration on the dorsal surface of the brainstem had no effect on the amplitude of rhythmic glutamate release in the NTS.
Neg (no) Regulation (effect) of Gene_expression (application) of P2 receptor in brainstem associated with medulla, glutamate and antagonist
7) Confidence 0.03 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538935 Disease Relevance 0 Pain Relevance 0.35
The relationship between changes in P2 receptor expression and the specific response of different cell types to injury is extremely complex and can be related to detrimental and/or beneficial effects.
Regulation (changes) of Gene_expression (expression) of P2 receptor associated with injury
8) Confidence 0.01 Published 2006 Journal Pharmacol. Ther. Section Abstract Doc Link 16102837 Disease Relevance 0.95 Pain Relevance 0.28

General Comments

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