INT12945

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Context Info
Confidence 0.41
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.61
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
spinal cord 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 9 100.00 Very High Very High Very High
ischemia 6 100.00 Very High Very High Very High
dexamethasone 5 99.88 Very High Very High Very High
Neurobehavioral 1 84.28 Quite High
adenocard 1 75.00 Quite High
Inflammation 32 67.52 Quite High
fibrosis 4 61.12 Quite High
anesthesia 3 60.96 Quite High
tolerance 1 39.80 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Spinal Cord Ischemia 6 100.00 Very High Very High Very High
Reperfusion Injury 1 100.00 Very High Very High Very High
Stress 30 98.76 Very High Very High Very High
Apoptosis 5 98.16 Very High Very High Very High
Diabetes Mellitus 120 97.84 Very High Very High Very High
Neurodegenerative Disease 1 85.80 High High
Glioma 2 75.00 Quite High
INFLAMMATION 32 67.52 Quite High
Atherosclerosis 4 63.16 Quite High
Keloid Scars 2 61.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone also reduced forskolin-stimulated CAT mRNA levels in C6 cells stably transfected with proenkephalin/CAT chimeric genes in the presence or absence of proteins synthesis.
Negative_regulation (reduced) of Positive_regulation (forskolin-stimulated) of CAT associated with dexamethasone
1) Confidence 0.41 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.13 Pain Relevance 0.23
We conclude that HBO-PC reduced spinal cord ischemia-reperfusion injury by increasing Mn-SOD, catalase, and Bcl-2, and by suppressing mitochondrial apoptosis pathway.
Negative_regulation (reduced) of Positive_regulation (increasing) of catalase in spinal cord associated with reperfusion injury, ischemia, apoptosis and spinal cord
2) Confidence 0.29 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.92 Pain Relevance 0.62
This was in conjunction with depletion of superoxide scavenger SOD and reduced glutathione along with an increase in the levels of antioxidant enzyme catalase.
Negative_regulation (depletion) of Positive_regulation (increase) of catalase
3) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.78 Pain Relevance 0.06
This was in conjunction with depletion of superoxide scavenger SOD and reduced glutathione along with an increase in the levels of antioxidant enzyme catalase.
Negative_regulation (reduced) of Positive_regulation (increase) of catalase
4) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.77 Pain Relevance 0.06

General Comments

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