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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 7.78
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts13) extracellular space (Adamts13) proteinaceous extracellular matrix (Adamts13)
Anatomy Link Frequency
plasma 2
platelet 1
Adamts13 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 4 99.84 Very High Very High Very High
Central nervous system 1 92.16 High High
Angina 5 55.48 Quite High
adenocard 1 50.32 Quite High
abdominal pain 2 44.88 Quite Low
fibrosis 1 42.40 Quite Low
Pain 1 39.36 Quite Low
addiction 1 6.32 Low Low
methotrexate 22 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 36 99.58 Very High Very High Very High
Thrombotic Thrombocytopenic Purpura 21 99.26 Very High Very High Very High
Hemolytic Uremic Syndrome 43 99.12 Very High Very High Very High
Thrombotic Microangiopathies 5 98.28 Very High Very High Very High
Cv General 3 Under Development 6 97.48 Very High Very High Very High
Renal Failure 11 95.16 Very High Very High Very High
Thrombosis Related Under Development 24 94.88 High High
Infection 11 93.20 High High
Malignant Neoplastic Disease 16 92.40 High High
Diarrhoea 4 91.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is known that they develop TTP within 2 to 8 wk of starting ticlopidine treatment and show severely deficient of ADAMTS13 activity with the presence of the inhibitor.
Negative_regulation (deficient) of ADAMTS13 associated with thrombotic thrombocytopenic purpura
1) Confidence 0.30 Published 2005 Journal Rinsho Byori Section Abstract Doc Link 16104532 Disease Relevance 1.16 Pain Relevance 0.17
There are no convincing data that this easily recognizable form of microangiopathy is related to any inborn or acquired deficiency of ADAMTS13, and plasma therapies are not justified on either theoretical or empirical grounds.
Negative_regulation (deficiency) of ADAMTS13 in plasma
2) Confidence 0.19 Published 2009 Journal Kidney Int. Suppl. Section Abstract Doc Link 19180128 Disease Relevance 1.35 Pain Relevance 0
Though there are conflicting data, TTP is most often associated with severe deficiencies of ADAMTS13 activity, whereas in HUS activity of this protease is relatively preserved.
Negative_regulation (deficiencies) of ADAMTS13 associated with hemolytic uremic syndrome
3) Confidence 0.14 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2613392 Disease Relevance 1.38 Pain Relevance 0.05
TTP is usually associated with a severe deficiency of ADAMTS13 [a metalloproteinase involved in the degradation of von Willebrand factor (vWF) multimers], causing excessive accumulation of ultra-large vWF multimers and platelet aggregation with organ failure.
Negative_regulation (deficiency) of ADAMTS13 in platelet associated with metalloproteinase and thrombotic thrombocytopenic purpura
4) Confidence 0.10 Published 2010 Journal Cardiovasc Hematol Disord Drug Targets Section Abstract Doc Link 20397971 Disease Relevance 1.52 Pain Relevance 0.10
MATERIALS AND METHODS: Plasma VWF and ADAMTS13 levels (mU/ml) were measured in 45 patients with UA, 55 with stable exertional angina (SEA) and 47 with chest pain syndrome (CPS) at the time of coronary angiography.
Negative_regulation (measured) of ADAMTS13 in Plasma
5) Confidence 0.10 Published 2008 Journal Thromb. Res. Section Body Doc Link 18295305 Disease Relevance 0.19 Pain Relevance 0
Nevertheless, recent studies have shown that disseminated cancer was associated with decreased ADAMTS13 activity, without anti-ADMTS13 antibody [27].
Negative_regulation (decreased) of ADAMTS13 associated with cancer
6) Confidence 0.03 Published 2006 Journal Crit Care Section Body Doc Link PMC1550893 Disease Relevance 2.17 Pain Relevance 0

General Comments

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