INT12948

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.67
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 6.46
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
aorta 6
astrocytes 4
liver 2
spinal cord 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 14 99.62 Very High Very High Very High
anesthesia 6 99.20 Very High Very High Very High
Spinal cord 44 98.24 Very High Very High Very High
ischemia 26 96.80 Very High Very High Very High
Inflammation 56 95.60 Very High Very High Very High
Paracetamol 6 92.60 High High
Glutamate 2 86.76 High High
B1 receptor 273 86.64 High High
antagonist 44 86.32 High High
cytokine 43 82.76 Quite High
Disease Link Frequency Relevance Heat
Stress 177 99.32 Very High Very High Very High
Diabetes Mellitus 185 98.68 Very High Very High Very High
Death 20 98.04 Very High Very High Very High
Spinal Cord Ischemia 6 96.80 Very High Very High Very High
INFLAMMATION 59 95.60 Very High Very High Very High
Pressure Volume 2 Under Development 1 95.52 Very High Very High Very High
Hepatotoxicity 6 91.96 High High
Body Weight 28 90.44 High High
Toxicity 4 89.24 High High
Disease 11 87.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone reduced forskolin-stimulated CAT expression from plasmids with 190 or more base-pairs of 5'-flanking sequence, an effect apparently involving multiple up-stream regions.
Positive_regulation (stimulated) of Gene_expression (expression) of CAT associated with dexamethasone
1) Confidence 0.67 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.14 Pain Relevance 0.23
However, dexamethasone plus forskolin caused a synergistic induction of CAT expression with the GRE+ oligo, no effect with the RGRE and an antagonistic effect with the Penk promoter alone and the GRE- oligo.
Positive_regulation (induction) of Gene_expression (expression) of CAT associated with dexamethasone
2) Confidence 0.67 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7755638 Disease Relevance 0 Pain Relevance 0.17
Dexamethasone also reduced forskolin-stimulated CAT mRNA levels in C6 cells stably transfected with proenkephalin/CAT chimeric genes in the presence or absence of proteins synthesis.
Positive_regulation (transfected) of Gene_expression (transfected) of CAT associated with dexamethasone
3) Confidence 0.49 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.13 Pain Relevance 0.22
Estrogen produced a dose-dependent increase in CAT activity in cotransfection assays with ERalpha expression vector and a 437PPE-CAT reporter construct containing 437 bp of the rat PPE gene promoter and the CAT reporter gene.
Positive_regulation (increase) of Gene_expression (produced) of CAT
4) Confidence 0.49 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11457489 Disease Relevance 0.08 Pain Relevance 0
The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.
Spec (may) Positive_regulation (influence) of Gene_expression (expression) of catalase
5) Confidence 0.49 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22
The observed decrease in oxidative stress was due to the better maintained CAT activity and increased SOD levels on attaining Trec 23°C and on recovery of Trec 37°C.
Positive_regulation (increased) of Gene_expression (levels) of CAT associated with stress
6) Confidence 0.49 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062147 Disease Relevance 0.79 Pain Relevance 0
On the other hand, it increased SOD and catalase levels in rat liver homogenates compared to diabetic rats, which were comparable to that of Glibenclamide-treated animals.
Positive_regulation (increased) of Gene_expression (levels) of catalase in liver associated with diabetes mellitus
7) Confidence 0.37 Published 2010 Journal International Journal of Diabetes in Developing Countries Section Body Doc Link PMC2859276 Disease Relevance 0.89 Pain Relevance 0
Thus, the increased expression of MnSOD and catalase in the aorta of 8-week glucose-fed rats is congruent with previous studies and may reflect a compensatory mechanism to the enhanced oxidative stress in glucose-fed rats.
Positive_regulation (increased) of Gene_expression (expression) of catalase in aorta associated with stress
8) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.82 Pain Relevance 0.39
HBO-PC enhanced activities of Mn-superoxide dismutase (Mn-SOD) and catalase, as well as the expression of Bcl-2 in the mitochondria in the normal spinal cord at 24 h after the last pretreatment (before spinal cord ischemia), and retained higher levels throughout the early reperfusion in the ischemic spinal cord.
Positive_regulation (enhanced) of Gene_expression (expression) of catalase in spinal cord associated with ischemia and spinal cord
9) Confidence 0.30 Published 2009 Journal J. Neurotrauma Section Abstract Doc Link 19196076 Disease Relevance 0.82 Pain Relevance 0.71
The level of SOD and catalase enzyme activities was measured using the SOD Assay Kit-WST and Catalase Assay kit (Sigma, St.
Positive_regulation (measured) of Gene_expression (kit) of Catalase
10) Confidence 0.27 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.28 Pain Relevance 0.03
Secondly, the protein expression of catalase was significantly increased in the aorta of 8-week glucose-fed rats and the one-week treatment with SSR240612 reduced it significantly (Figure 12).
Positive_regulation (increased) of Gene_expression (expression) of catalase in aorta
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.18 Pain Relevance 0.32
The blots were cut in pieces according to the molecular weight of the protein and then incubated with the specific antibodies for MnSOD (1/500, cat number: sc-18503), catalase (1/500, cat number: sc-34285), dynein (1/5000, cat number: sc-13524) and ?
Positive_regulation (incubated) of Gene_expression (antibodies) of catalase
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0 Pain Relevance 0.11
increases over 24 hours were almost completely stopped by apocynin, catalase and EUKs (Fig. 6), indicating that A?
Positive_regulation (increases) of Gene_expression (stopped) of catalase
13) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1574293 Disease Relevance 0 Pain Relevance 0.04
Intake of green tea extracts also increases the activity of superoxide dismutase in serum and the expression of catalase in the aorta; these enzymes are implicated in cellular protection against reactive oxygen species [78,79].
Positive_regulation (increases) of Gene_expression (expression) of catalase in aorta
14) Confidence 0.13 Published 2010 Journal Chin Med Section Body Doc Link PMC2855614 Disease Relevance 0.32 Pain Relevance 0
Regarding the antioxidant activity, C chinensis ethanolic extract exhibited a significant effect (P<0.05) by increasing levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and by reducing malondialdehyde (MDA) levels.
Positive_regulation (increasing) of Gene_expression (levels) of catalase
15) Confidence 0.10 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17145147 Disease Relevance 0.38 Pain Relevance 0.53
Cu/Zn SOD overexpressing astrocytes also survived better that control astrocytes after oxygen glucose deprivation, in the absence of glutathione peroxidase upregulation and with a lower catalase upregulation in comparison to control astrocytes [50].
Positive_regulation (upregulation) of Gene_expression (overexpressing) of catalase in astrocytes
16) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1462999 Disease Relevance 0.27 Pain Relevance 0.03
Cu/Zn SOD overexpressing astrocytes also survived better that control astrocytes after oxygen glucose deprivation, in the absence of glutathione peroxidase upregulation and with a lower catalase upregulation in comparison to control astrocytes [50].
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of catalase in astrocytes
17) Confidence 0.07 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1462999 Disease Relevance 0.27 Pain Relevance 0.03
Coadministration of the PKC inhibitor chelerythrine (10-7M) or the O-2 scavenger polyethylene glycol superoxide dismutase and catalase (SODCAT) with NOC/oFQ (10-10M) partially prevented hypotensive pial dilation impairment (34I2 vs 28I1% for SODCAT).
Positive_regulation (Coadministration) of Spec (partially) Gene_expression (Coadministration) of catalase
18) Confidence 0.06 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11782666 Disease Relevance 0.17 Pain Relevance 0
induces the expression of antioxidant enzymes including superoxide dismutase and catalase [49, 50].
Positive_regulation (induces) of Gene_expression (expression) of catalase
19) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2938460 Disease Relevance 0.69 Pain Relevance 0.09

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox