INT129488

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2008
Negated 4
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.39
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
plasma 2
DRG 2
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
Sciatic nerve 2 100.00 Very High Very High Very High
Inflammation 4 95.76 Very High Very High Very High
Pain 7 94.56 High High
Dismenorea 2 92.40 High High
antagonist 18 91.20 High High
Brush evoked pain 2 91.20 High High
Hyperalgesia 4 89.32 High High
withdrawal 1 86.88 High High
IPN 1 78.92 Quite High
cytokine 2 76.64 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 15 100.00 Very High Very High Very High
Diabetes Mellitus 10 100.00 Very High Very High Very High
Targeted Disruption 1 97.60 Very High Very High Very High
Pulmonary Hypertension 71 95.92 Very High Very High Very High
INFLAMMATION 4 95.76 Very High Very High Very High
Pain 5 94.56 High High
Dysmenorrhea 2 92.40 High High
Osteoporosis 20 92.16 High High
Neuropathic Pain 3 91.20 High High
Hyperalgesia 4 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Whereas ETA receptor expression at both protein and mRNA levels was not affected by IL-1beta treatment, we demonstrated an unexpected predominance of the ETB receptor subtype under this inflammatory condition.
Neg (not) Regulation (not) of Gene_expression (expression) of ETA associated with inflammation
1) Confidence 0.51 Published 2005 Journal Endocrinology Section Abstract Doc Link 16109787 Disease Relevance 0.19 Pain Relevance 0.18
Endothelin-receptor selectivity and its vasoconstriction and vasodilation effects
Regulation (effects) of Gene_expression (selectivity) of Endothelin-receptor associated with increased venous pressure under development
2) Confidence 0.36 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.88 Pain Relevance 0.13
Whereas ETA receptor expression at both protein and mRNA levels was not affected by IL-1beta treatment, we demonstrated an unexpected predominance of the ETB receptor subtype under this inflammatory condition.
Neg (not) Regulation (affected) of Gene_expression (expression) of ETA associated with inflammation
3) Confidence 0.23 Published 2005 Journal Endocrinology Section Abstract Doc Link 16109787 Disease Relevance 0.19 Pain Relevance 0.18
In contrast, the expression of ETAR in either sciatic nerves or DRG of diabetic rats was not altered.
Neg (not) Regulation (altered) of Gene_expression (expression) of ETAR in DRG associated with diabetes mellitus and sciatic nerve
4) Confidence 0.20 Published 2006 Journal Exp. Neurol. Section Abstract Doc Link 16806184 Disease Relevance 1.67 Pain Relevance 0.96
We found out that comparison regardless of gender among osteoporotics, osteopenics and normals and comparison of female osteoporotics, osteopenics and normals yielded no significant differences regarding plasma ET levels.
Neg (no) Regulation (regarding) of Gene_expression (levels) of ET in plasma
5) Confidence 0.03 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.46 Pain Relevance 0

General Comments

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