INT129490

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.91
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleolus (Casp3) nucleus (Casp3) intracellular (Casp3)
Anatomy Link Frequency
poly 2
muscle 2
cleavage 2
Casp3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 76 98.72 Very High Very High Very High
local anesthetic 5 87.88 High High
Inflammation 49 80.32 Quite High
Pain 1 74.32 Quite High
Hippocampus 41 74.16 Quite High
cytokine 18 34.40 Quite Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 70 98.92 Very High Very High Very High
Cv Unclassified Under Development 65 98.72 Very High Very High Very High
Death 39 91.44 High High
Chronic Renal Failure 28 90.80 High High
Diabetes Mellitus 5 88.80 High High
Hypertension 24 86.32 High High
Injury 14 81.08 Quite High
Drug Induced Neurotoxicity 1 80.92 Quite High
INFLAMMATION 59 80.32 Quite High
Necrosis 3 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, our other results showed that cleaved caspase-3 was significantly decreased by PZH preventive treatment in ischemia (Figure 3).
Negative_regulation (decreased) of Protein_catabolism (cleaved) of caspase-3 associated with ischemia
1) Confidence 0.22 Published 2010 Journal Chin Med Section Body Doc Link PMC2984508 Disease Relevance 1.46 Pain Relevance 0.19
Cleaved caspase-3 was strongly present in the I/Ri group and iCORM-2 treated group, whereas caspase-3 cleavage was markedly inhibited in CORM-2 treated rats.
Negative_regulation (inhibited) of Protein_catabolism (cleavage) of caspase-3 in cleavage
2) Confidence 0.12 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2873601 Disease Relevance 1.00 Pain Relevance 0
The protein-cleaving action of caspase-3 is important because blocking caspase-3 will reduce overall protein degradation in muscle [40].
Negative_regulation (reduce) of Protein_catabolism (degradation) of caspase-3 in muscle
3) Confidence 0.10 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC2259254 Disease Relevance 0.77 Pain Relevance 0.11
The bupivacaine-induced generation of reactive oxygen species (ROS), which was initiated within 5 hrs and preceded the activation of caspase-3 and poly ADP-ribose polymerase (PARP) degradation, was suggested to trigger apoptosis, exhibited by Hoechst 33258 nuclear staining and DNA fragmentation.
Negative_regulation (preceded) of Protein_catabolism (degradation) of caspase-3 in poly associated with apoptosis
4) Confidence 0.02 Published 2005 Journal J. Dent. Res. Section Abstract Doc Link 16109997 Disease Relevance 0.68 Pain Relevance 0.41

General Comments

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