INT129492

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 11
Total Number 12
Disease Relevance 6.56
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
proteinaceous extracellular matrix (Hpse) nucleus (Hpse) carbohydrate metabolic process (Hpse)
Anatomy Link Frequency
liver 1
Hpse (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 16 99.68 Very High Very High Very High
tricyclic antidepressant 5 98.08 Very High Very High Very High
fluoxetine 5 97.60 Very High Very High Very High
sSRI 4 95.92 Very High Very High Very High
depression 5 94.40 High High
antidepressant 1 87.20 High High
monoamine 1 79.08 Quite High
Nerve growth factor 8 78.04 Quite High
amygdala 3 74.80 Quite High
Locus ceruleus 2 74.00 Quite High
Disease Link Frequency Relevance Heat
Lung Cancer 273 100.00 Very High Very High Very High
Solid Tumor 10 98.88 Very High Very High Very High
Pancreatic Cancer 4 98.80 Very High Very High Very High
Metastasis 22 97.36 Very High Very High Very High
Cancer 124 96.92 Very High Very High Very High
Adenocarcinoma 14 96.76 Very High Very High Very High
Albuminuria 1 96.68 Very High Very High Very High
Metabolic Syndrome 35 95.20 Very High Very High Very High
Adhesions 19 94.96 High High
Disease 28 94.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heparanase expression was determined and correlated to tumor response, time to progression and survival.
Gene_expression (expression) of Heparanase
1) Confidence 0.75 Published 2005 Journal Pancreatology Section Body Doc Link 16110255 Disease Relevance 0 Pain Relevance 0
RESULTS: Heparanase expression was detectable by immunohistochemistry in 36 out of 58 (62%) patients analyzed.
Spec (analyzed) Gene_expression (expression) of Heparanase
2) Confidence 0.75 Published 2005 Journal Pancreatology Section Body Doc Link 16110255 Disease Relevance 0 Pain Relevance 0
Predictive value of heparanase expression in the palliative therapy of pancreatic cancer.
Gene_expression (expression) of heparanase associated with pancreatic cancer and palliative
3) Confidence 0.65 Published 2005 Journal Pancreatology Section Title Doc Link 16110255 Disease Relevance 0.52 Pain Relevance 0.36
CONCLUSION: Heparanase expression may be a useful marker to predict response to palliative therapy with gemcitabine in PDA.


Gene_expression (expression) of Heparanase
4) Confidence 0.65 Published 2005 Journal Pancreatology Section Body Doc Link 16110255 Disease Relevance 0 Pain Relevance 0
Basal HPA axis activity and expression of its central regulatory markers are age-dependent in mice [42].
Gene_expression (expression) of HPA
5) Confidence 0.15 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2872226 Disease Relevance 1.54 Pain Relevance 0
Genes regulated by ALR include ECM-degrading enzyme, heparanase, uPA/PL, BH-protocadherin, L1CAM, ALCAM and Keratin17, consistent with decreased expression of these molecules.
Gene_expression (include) of heparanase
6) Confidence 0.08 Published 2008 Journal Nuclear Receptor Signaling Section Body Doc Link PMC2254332 Disease Relevance 0.36 Pain Relevance 0.03
To test this hypothesis, we measured HPA axis-relevant gene expression in male C57BL/6 mice treated for 5 weeks with 10 mg/kg/day fluoxetine.
Gene_expression (expression) of HPA axis-relevant gene associated with fluoxetine
7) Confidence 0.07 Published 2010 Journal Eur. J. Neurosci. Section Abstract Doc Link 20374287 Disease Relevance 0.58 Pain Relevance 0.96
However, we did not observe changes in Hsf1 expression in our transcript profiling studies and earlier studies showed that HSF1 and HSF2 expression and binding to HSE was not altered by WY exposure in the rat liver [64].
Gene_expression (expression) of HSE in liver
8) Confidence 0.06 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.84 Pain Relevance 0
More recently, van den Hoven et al argued against a prominent role of such heparan sulphates in contributing to renal permeability showing that over-expression of human-heparanase in B6 mice resulted only in a low, but statistically significant, higher level of albuminuria compared with controls [28].
Gene_expression (expression) of human-heparanase associated with albuminuria
9) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2999536 Disease Relevance 0.21 Pain Relevance 0.03
We subsequently studied the anatomic site-related expression of angiogenic molecules in MM, including VEGF, IL-8, bFGF and heparanase.
Gene_expression (expression) of heparanase associated with lung cancer
10) Confidence 0.02 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.25 Pain Relevance 0.11
We found significantly lower heparanase and bFGF expression in effusions compared with solid tumors (Davidson, 2004) (Figures 1-F, 1-G).
Gene_expression (expression) of heparanase associated with solid tumor
11) Confidence 0.02 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.17 Pain Relevance 0.10
Maturation/export rates were measured by acquisition of endoglycosidase H resistance.
Gene_expression (resistance) of endoglycosidase H
12) Confidence 0.00 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18240209 Disease Relevance 0.09 Pain Relevance 0

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