INT129493

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Context Info
Confidence 0.55
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.81
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Hpse) extracellular region (Hpse) cell adhesion (Hpse)
proteinaceous extracellular matrix (Hpse) nucleus (Hpse) carbohydrate metabolic process (Hpse)
Anatomy Link Frequency
extracellular matrix 3
Hpse (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 4 97.96 Very High Very High Very High
Nerve growth factor 8 74.64 Quite High
metalloproteinase 56 5.00 Very Low Very Low Very Low
chemokine 16 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lung Cancer 272 98.20 Very High Very High Very High
Cancer 113 96.52 Very High Very High Very High
Metastasis 19 96.24 Very High Very High Very High
Disease 22 91.36 High High
Adenocarcinoma 5 89.36 High High
Solid Tumor 10 81.76 Quite High
Necrosis 2 76.40 Quite High
Pancreatic Cancer 1 75.00 Quite High
Breast Cancer 2 72.72 Quite High
Malignant Neoplastic Disease 22 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heparanase, an endoglycosidase degrading components of the extracellular matrix, promotes cell invasion, is involved in angiogenesis and plays a role in tumor metastases.
Protein_catabolism (degrading) of Heparanase in extracellular matrix associated with cancer and metastasis
1) Confidence 0.55 Published 2005 Journal Pancreatology Section Abstract Doc Link 16110255 Disease Relevance 0.53 Pain Relevance 0.36
Heparanase is an endoglycosidase that degrades heparan sulfate in the extracellular matrix (ECM) and cell surfaces and has a role in cancer metastasis and angiogenesis (Edovitsky, 2004).
Protein_catabolism (degrades) of Heparanase in extracellular matrix associated with cancer and metastasis
2) Confidence 0.02 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.14 Pain Relevance 0.11
Heparanase is an endoglycosidase that degrades heparan sulfate in the extracellular matrix (ECM) and cell surfaces and has a role in cancer metastasis and angiogenesis (Edovitsky, 2004).
Protein_catabolism (degrades) of endoglycosidase in extracellular matrix associated with cancer and metastasis
3) Confidence 0.02 Published 2007 Journal Biomarker Insights Section Body Doc Link PMC2717840 Disease Relevance 1.14 Pain Relevance 0.11

General Comments

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