INT1295

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Context Info
Confidence 0.48
First Reported 1976
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 85
Total Number 88
Disease Relevance 12.92
Pain Relevance 42.80

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signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) cell-cell signaling (Pomc) cytoplasm (Pomc)
Anatomy Link Frequency
brain 9
EL4 7
melanocyte 5
peritoneal macrophages 4
plasma 2
Pomc (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 127 100.00 Very High Very High Very High
Enkephalin 99 100.00 Very High Very High Very High
Morphine 91 100.00 Very High Very High Very High
Opioid 78 100.00 Very High Very High Very High
narcan 49 100.00 Very High Very High Very High
Endogenous opioid 25 100.00 Very High Very High Very High
antinociception 21 100.00 Very High Very High Very High
melanocortin 1 receptor 18 100.00 Very High Very High Very High
Dynorphin 10 100.00 Very High Very High Very High
mu opioid receptor 10 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 122 100.00 Very High Very High Very High
INFLAMMATION 26 100.00 Very High Very High Very High
Hyperphagia 4 99.76 Very High Very High Very High
Targeted Disruption 70 99.08 Very High Very High Very High
Urological Neuroanatomy 4 99.00 Very High Very High Very High
Infection 3 99.00 Very High Very High Very High
Thymoma 17 98.88 Very High Very High Very High
Obesity 63 98.72 Very High Very High Very High
Skin Cancer 114 98.60 Very High Very High Very High
Sprains And Strains 16 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was shown that [3H]immunorphin binds with a high affinity to the non-opioid beta-endorphin receptor of mouse peritoneal macrophages (Kd 2.4 +/- 0.1 nM).
beta-endorphin receptor Binding (binds) of in peritoneal macrophages associated with opioid
1) Confidence 0.48 Published 2008 Journal Bioorg. Khim. Section Abstract Doc Link 18365735 Disease Relevance 0 Pain Relevance 0.26
[Binding of beta-endorphin and its fragments to the non-opiod receptor of murine peritoneal macrophages].
beta-endorphin Binding (Binding) of in peritoneal macrophages associated with narcan
2) Confidence 0.48 Published 2008 Journal Bioorg. Khim. Section Title Doc Link 18365735 Disease Relevance 0 Pain Relevance 0.30
Receptor mutations in the mouse (E92K, L98P), cow (L99P), fox (C125R), and sheep (D119N) cluster near the membrane/extracellular junctions of the second and third transmembrane domains, an acidic domain that is the likely site of electrostatic interaction with an arginine residue in the ligand, alpha-MSH.
alpha-MSH Binding (interaction) of
3) Confidence 0.48 Published 1998 Journal Mol. Endocrinol. Section Abstract Doc Link 9544994 Disease Relevance 0 Pain Relevance 0.12
We suggest that binding of beta-endorphin to such nonopioid binding sites may precede its apparent effects on the proliferation of T-lymphocytes (5,6).
beta-endorphin Binding (binding) of in T-lymphocytes
4) Confidence 0.48 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2997656 Disease Relevance 0.15 Pain Relevance 0.30
Speculations on the mode of interaction between endorphins and ACTH in the global response to stress are discussed.
ACTH Binding (interaction) of associated with stress
5) Confidence 0.47 Published 1980 Journal Neurosci Biobehav Rev Section Abstract Doc Link 6250104 Disease Relevance 0.59 Pain Relevance 0.18
Interaction between ACTH fragments, brain opiate receptors and morphine-induced analgesia.
ACTH Binding (Interaction) of in brain associated with opiate, analgesia and morphine
6) Confidence 0.47 Published 1976 Journal Eur. J. Pharmacol. Section Title Doc Link 185067 Disease Relevance 0 Pain Relevance 0.65
Several antisera which crossreact with both beta LPH and beta-endorphin did not react with any region of the lamprey pituitary.
beta-endorphin Binding (crossreact) of in pituitary
7) Confidence 0.47 Published 1984 Journal Cell Tissue Res. Section Abstract Doc Link 6321029 Disease Relevance 0 Pain Relevance 0.28
Recombinant IL-1s, however, significantly enhanced specific binding of 125I-beta-endorphin (125I-beta-END) and of D-ala2-(tyrosyl-3,5-3H)enkephalin-(5-D-leucine) (3H-D-ALA), equipotently and in a concentration-dependent manner with maximal activity occurring at a concentration of 10 LAF units/ml.
beta-endorphin Binding (binding) of associated with enkephalin
8) Confidence 0.47 Published 1989 Journal J. Neurosci. Res. Section Abstract Doc Link 2468786 Disease Relevance 0 Pain Relevance 0.56
Although Na+, K+, Ca2+, Mg2+ were found individually to exert a profound inhibition on the binding, the combined salt solution (Tyrode) did not abolish the specific binding of tritiated beta-endorphin to the mouse brain membrane preparations.
beta-endorphin Binding (binding) of in brain
9) Confidence 0.46 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6301856 Disease Relevance 0 Pain Relevance 0.16
Binding of human beta-endorphin to mouse brain membrane preparations has been characterized using the tritiated hormone as primary ligand.
beta-endorphin Binding (Binding) of in brain
10) Confidence 0.46 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6301856 Disease Relevance 0 Pain Relevance 0.15
Naloxone, a competitive inhibitor of beta-endorphin opioid receptor interactions, abrogated the enhancing effects of beta-endorphin on LPS-induced IL-1 production.
beta-endorphin Binding (interactions) of associated with narcan and opioid receptor
11) Confidence 0.46 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.29
Thus, beta-endorphin-opioid receptor interactions result in enhanced production of immunomodulators such as IL-1.
beta-endorphin-opioid receptor Binding (interactions) of associated with opioid receptor
12) Confidence 0.46 Published 1989 Journal Int. Immunol. Section Abstract Doc Link 2535139 Disease Relevance 0 Pain Relevance 0.31
Physiologic significance of alphaMSH-MC1R interaction in host defense against infection is discussed.
alphaMSH Binding (interaction) of associated with melanocortin 1 receptor and infection
13) Confidence 0.44 Published 2007 Journal J. Vet. Med. Sci. Section Abstract Doc Link 17917378 Disease Relevance 0.60 Pain Relevance 0.43
The 83,000 and 52,000 M(r) subunits are disulfide linked and noncovalently associated with the other subunits, with binding of labeled ACTH localized to the 83,000 M(r) subunit.
ACTH Binding (binding) of
14) Confidence 0.44 Published 1994 Journal Immunomethods Section Abstract Doc Link 7874440 Disease Relevance 0 Pain Relevance 0.16
Binding of 125I-labeled camel beta-endorphin (125I-beta C-endorphin) to cells of several mouse thymoma cell lines was examined and was highest to EL4 cells. 125I-beta C-endorphin binding to EL4 cells was temperature-dependent; it was further characterized at 4 degrees C and exhibited saturability, complete reversibility, structural specificity and pH-dependence. 125I-beta C-endorphin binding was not inhibited by the opioid pentapeptides [Leu] enkephalin or [Met] enkephalin (which share common sequences with the N-terminus of beta C-endorphin) or by the N-terminal beta C-endorphin fragments beta C-endorphin (1-16) or beta C-endorphin (1-27).
C-endorphin Binding (binding) of in EL4 associated with addiction, thymoma, enkephalin and opioid
15) Confidence 0.42 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2997656 Disease Relevance 0.17 Pain Relevance 0.34
In contrast, binding was inhibited by beta C-endorphin (1-31), indicating that beta C-endorphin binding to EL4 cells was with a C-terminal beta C-endorphin segment.
C-endorphin Binding (binding) of in EL4
16) Confidence 0.42 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2997656 Disease Relevance 0.15 Pain Relevance 0.31
Binding of 125I-labeled camel beta-endorphin (125I-beta C-endorphin) to cells of several mouse thymoma cell lines was examined and was highest to EL4 cells. 125I-beta C-endorphin binding to EL4 cells was temperature-dependent; it was further characterized at 4 degrees C and exhibited saturability, complete reversibility, structural specificity and pH-dependence. 125I-beta C-endorphin binding was not inhibited by the opioid pentapeptides [Leu] enkephalin or [Met] enkephalin (which share common sequences with the N-terminus of beta C-endorphin) or by the N-terminal beta C-endorphin fragments beta C-endorphin (1-16) or beta C-endorphin (1-27).
C-endorphin Binding (binding) of in EL4 associated with addiction, thymoma, enkephalin and opioid
17) Confidence 0.42 Published 1985 Journal Neuropeptides Section Abstract Doc Link 2997656 Disease Relevance 0.17 Pain Relevance 0.32
Likewise, NT, and probably beta-endorphin, may interact with other neurochemical processes that are involved in the mechanism of ethanol-induced anesthesia and that differ genetically in LS and SS mice.
beta-endorphin Binding (interact) of associated with anesthesia
18) Confidence 0.41 Published 1987 Journal Brain Res. Section Abstract Doc Link 2949796 Disease Relevance 0.06 Pain Relevance 0.53
These results suggest the involvement of beta-endorphin in swim-induced antinociception in female mice and its interaction with some peripheral opioid receptor(s) other than the mu-receptor.
beta-endorphin Binding (interaction) of associated with antinociception and opioid receptor
19) Confidence 0.37 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2533477 Disease Relevance 0 Pain Relevance 0.75
Beta-endorphin is an endogenous opioid peptide that is released during stress and has been associated with many physiological functions.
Beta-endorphin Binding (associated) of associated with stress and endogenous opioid
20) Confidence 0.37 Published 2003 Journal Brain Res. Section Abstract Doc Link 12834911 Disease Relevance 0.33 Pain Relevance 0.10

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