INT12950

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 1983
Last Reported 2010
Negated 0
Speculated 3
Reported most in Abstract
Documents 85
Total Number 88
Disease Relevance 35.94
Pain Relevance 15.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 7
aorta 4
plasma 2
brain 2
kidney 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 78 100.00 Very High Very High Very High
Hippocampus 21 100.00 Very High Very High Very High
cerebral cortex 13 99.84 Very High Very High Very High
Sciatic nerve 5 99.84 Very High Very High Very High
dexamethasone 20 99.40 Very High Very High Very High
Inflammation 342 99.30 Very High Very High Very High
antagonist 144 99.22 Very High Very High Very High
B1 receptor 910 99.00 Very High Very High Very High
Spinal cord 132 98.64 Very High Very High Very High
Paracetamol 39 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 163 100.00 Very High Very High Very High
Stress 908 99.40 Very High Very High Very High
Urological Neuroanatomy 64 99.36 Very High Very High Very High
INFLAMMATION 397 99.30 Very High Very High Very High
Appetite Loss 8 99.18 Very High Very High Very High
Diabetes Mellitus 986 99.16 Very High Very High Very High
Death 110 99.16 Very High Very High Very High
Congenital Anomalies 59 99.04 Very High Very High Very High
Poisoning 49 98.64 Very High Very High Very High
Cv General 3 Under Development 16 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone reduced forskolin-stimulated CAT expression from plasmids with 190 or more base-pairs of 5'-flanking sequence, an effect apparently involving multiple up-stream regions.
Gene_expression (expression) of CAT associated with dexamethasone
1) Confidence 0.75 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.14 Pain Relevance 0.23
There was also a significant decrease in CAT levels in NAP PS group (P < 0.001), but no significant difference in cardiac tissue CAT levels was observed in TMZ PS group (P > 0.05) as compared to normal CTR group.
Gene_expression (levels) of CAT
2) Confidence 0.75 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0 Pain Relevance 0
However, dexamethasone plus forskolin caused a synergistic induction of CAT expression with the GRE+ oligo, no effect with the RGRE and an antagonistic effect with the Penk promoter alone and the GRE- oligo.
Gene_expression (expression) of CAT associated with dexamethasone
3) Confidence 0.75 Published 1995 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 7755638 Disease Relevance 0 Pain Relevance 0.17
CAT activity was expressed as U/mg protein in tissue samples.


Gene_expression (expressed) of CAT
4) Confidence 0.75 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0 Pain Relevance 0
The results of the present studies also reveal that melatonin may influence the expression of Cu-Zn SOD, catalase, cyclooxygenase as well as alpha-actinin whose levels were found to be altered, following piroxicam treatment.
Gene_expression (expression) of catalase
5) Confidence 0.75 Published 2004 Journal J. Pineal Res. Section Abstract Doc Link 15009511 Disease Relevance 0.14 Pain Relevance 0.22
Myocardial CAT: In the DOX group, there was a significant decrease in CAT level compared to normal CTR group (P < 0.001).
Gene_expression (group) of CAT
6) Confidence 0.65 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0 Pain Relevance 0
Although SOD activities slightly increased, there was a decrease in the GSH contents and GSH-Px, CAT activities in cerebral cortex, hippocampus, spinal cord and serum after 2, 4, 8 or 12 weeks' CS(2) intoxication and at gait score of 2, 3, or 4.
Gene_expression (activities) of CAT in cerebral cortex associated with hippocampus, cerebral cortex, poisoning and spinal cord
7) Confidence 0.65 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19070609 Disease Relevance 0.30 Pain Relevance 0.51
The rats intoxicated with acetaminophen showed significant elevation in the levels of lipid peroxides with decreased levels of protein, GSH, SOD, CAT and impaired tricarboxylic acid cycle enzyme activities.
Gene_expression (levels) of CAT associated with paracetamol
8) Confidence 0.65 Published 2005 Journal Chemosphere Section Abstract Doc Link 16168751 Disease Relevance 0.24 Pain Relevance 0.33
The observed decrease in oxidative stress was due to the better maintained CAT activity and increased SOD levels on attaining Trec 23°C and on recovery of Trec 37°C.
Gene_expression (levels) of CAT associated with stress
9) Confidence 0.65 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062147 Disease Relevance 0.79 Pain Relevance 0
Estrogen produced a dose-dependent increase in CAT activity in cotransfection assays with ERalpha expression vector and a 437PPE-CAT reporter construct containing 437 bp of the rat PPE gene promoter and the CAT reporter gene.
Gene_expression (produced) of CAT
10) Confidence 0.65 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11457489 Disease Relevance 0.08 Pain Relevance 0
The activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT), and the levels of malondialdehyde (MDA) were measured in the supernatant, which was obtained by centrifugation at 5,000 rpm.
Gene_expression (enzymes) of CAT
11) Confidence 0.65 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.11 Pain Relevance 0.03
Maximum stimulation of transiently expressed CAT activity by forskolin required more than 145 and 190 or fewer base pairs of 5'-flanking sequence, implicating sequences up-stream from the previously described cAMP-inducible enhancer.
Gene_expression (expressed) of CAT
12) Confidence 0.65 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.15 Pain Relevance 0.23
Dexamethasone also reduced forskolin-stimulated CAT mRNA levels in C6 cells stably transfected with proenkephalin/CAT chimeric genes in the presence or absence of proteins synthesis.
Gene_expression (transfected) of CAT associated with dexamethasone
13) Confidence 0.65 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.13 Pain Relevance 0.22
Antioxidant status in liver such as activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase and glutathione-S-transferase (GST), a phase II enzyme, and levels of reduced glutathione (GSH) were declined significantly (p<0.01) in the acetaminophen alone treated animals (control group).
Gene_expression (activities) of CAT in liver associated with paracetamol
14) Confidence 0.65 Published 2007 Journal Food Chem. Toxicol. Section Abstract Doc Link 17637489 Disease Relevance 0.25 Pain Relevance 0.56
We too observed that CCl4 challenge significantly decreased the levels of SOD and catalase in liver and kidney.
Gene_expression (levels) of catalase in liver
15) Confidence 0.61 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.56 Pain Relevance 0
Blockade of ethanol induced conditioned taste aversion by 3-amino-1,2,4-triazole: evidence for catalase mediated synthesis of acetaldehyde in rat brain.
Gene_expression (synthesis) of catalase in brain associated with appetite loss
16) Confidence 0.60 Published 1985 Journal Life Sci. Section Title Doc Link 2999539 Disease Relevance 0.66 Pain Relevance 0.07
Doxorubicin-induced a significant (P < 0.001) increase in the serum lactate dehydrogenase, cardiac thiobarbituric acid-reactive substance and catalase levels and a significant (P < 0.001) decrease in the cardiac glutathione and superoxide dismutase levels, which were significantly (P < 0.001) aggravated by diclofenac sodium treatment.
Gene_expression (levels) of catalase associated with diclofenac
17) Confidence 0.60 Published 2010 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 19920767 Disease Relevance 0.45 Pain Relevance 0.44
Catalase (CAT) was assayed colorimetrically at 620 nm and was expressed as micromoles of H2O2 consumed per minute per mg of protein; using the method described by Sinha.36 The reaction mixture (1.5 mL, volume) contained 1.0 mL of 0.01 M pH 7 phosphate buffer, 0.1 mL of tissue homogenate and 0.4 mL of 2 M H2O2.
Gene_expression (expressed) of Catalase
18) Confidence 0.59 Published 2010 Journal Int J Gen Med Section Body Doc Link PMC2880350 Disease Relevance 0.13 Pain Relevance 0
Regarding the antioxidant activity, C chinensis ethanolic extract exhibited a significant effect (P<0.05) by increasing levels of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx), and by reducing malondialdehyde (MDA) levels.
Gene_expression (levels) of CAT
19) Confidence 0.58 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 17145147 Disease Relevance 0.38 Pain Relevance 0.53
Assay of glutathione reductase and catalase activity
Gene_expression (activity) of catalase
20) Confidence 0.55 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2600521 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox