INT129505

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.09
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Slc17a7)
Anatomy Link Frequency
neurons 2
ganglia 1
Slc17a7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 40 100.00 Very High Very High Very High
antagonist 23 98.20 Very High Very High Very High
antidepressant 15 97.28 Very High Very High Very High
nociceptor 18 95.56 Very High Very High Very High
spinal dorsal horn 4 86.96 High High
depression 3 83.68 Quite High
Serotonin 3 81.52 Quite High
noradrenaline 1 75.84 Quite High
Glutamate receptor 5 75.72 Quite High
Spinal cord 7 75.00 Quite High
Disease Link Frequency Relevance Heat
Cough 144 98.04 Very High Very High Very High
Psychosis 1 91.04 High High
Depression 3 83.68 Quite High
Serotonin Syndrome 1 81.88 Quite High
Fever 1 74.48 Quite High
Disease 43 71.12 Quite High
Nociception 3 66.12 Quite High
Catalepsy 2 63.76 Quite High
Parkinson's Disease 6 58.24 Quite High
Ataxia 7 50.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Still, little is known on the modalities of VGLUT1 and VGLUT2 regulations in response to pharmacological or physiological stimuli.
Regulation (regulations) of VGLUT1
1) Confidence 0.37 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16111724 Disease Relevance 0.09 Pain Relevance 0.33
Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.
Regulation (immunoreactivities) of VGluT1 in neurons associated with glutamate
2) Confidence 0.26 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.84
However, memantine (10 mg/kg i.p.) had no effect on the CNS expression pattern of the vesicular glutamate transporter VGLUT1, upregulation of which has been proposed to be a useful marker for antidepressant activity [178].
Neg (no) Regulation (effect) of VGLUT1 associated with antidepressant and glutamate
3) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.48 Pain Relevance 0.57
3 Na+/K+ ATPase, vGlut1 and vGlut2 immunoreactivity were not significantly different to the size of cough receptor neurons.
Regulation (immunoreactivity) of vGlut1 in neurons associated with cough
4) Confidence 0.01 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.45 Pain Relevance 0.36
3 Na+/K+ ATPase, vGlut1 and vGlut2 immunoreactivity was not universally expressed by all neurons in the nodose ganglia (data not directly shown but can inferred from Fig 3).
Regulation (immunoreactivity) of vGlut1 in ganglia
5) Confidence 0.01 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0 Pain Relevance 0

General Comments

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