INT129505

Context Info Confidence 0.37 First Reported 2005 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 1.09 Pain Relevance 2.11

transmembrane transport (Slc17a7)

Anatomy Link Frequency neurons 2 ganglia 1 Slc17a7 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Glutamate 40 100.00 antagonist 23 98.20 antidepressant 15 97.28 nociceptor 18 95.56 spinal dorsal horn 4 86.96 depression 3 83.68 Serotonin 3 81.52 noradrenaline 1 75.84 Glutamate receptor 5 75.72 Spinal cord 7 75.00

Disease Link Frequency Relevance Heat Cough 144 98.04 Psychosis 1 91.04 Depression 3 83.68 Serotonin Syndrome 1 81.88 Fever 1 74.48 Disease 43 71.12 Nociception 3 66.12 Catalepsy 2 63.76 Parkinson's Disease 6 58.24 Ataxia 7 50.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Still, little is known on the modalities of VGLUT1 and VGLUT2 regulations in response to pharmacological or physiological stimuli.

Regulation (regulations) of VGLUT1

1) Confidence 0.37 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16111724 Disease Relevance 0.09 Pain Relevance 0.33

Immunohistochemistry showed glutamate- and vesicular glutamate transporter1 (VGluT1)-positive fibers in the cervix, glutamate- and VGluT1-expressing neurons in the DRG, some of which also exhibited retrograde tracer from cervical injections, and VGluT1 and mGluR5 immunoreactivities in the L6-S1 spinal dorsal horns.

Regulation (immunoreactivities) of VGluT1 in neurons associated with glutamate

2) Confidence 0.26 Published 2007 Journal J. Neurosci. Res. Section Abstract Doc Link 17304580 Disease Relevance 0.07 Pain Relevance 0.84

However, memantine (10 mg/kg i.p.) had no effect on the CNS expression pattern of the vesicular glutamate transporter VGLUT1, upregulation of which has been proposed to be a useful marker for antidepressant activity [178].

Neg (no) Regulation (effect) of VGLUT1 associated with antidepressant and glutamate

3) Confidence 0.10 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645549 Disease Relevance 0.48 Pain Relevance 0.57

3 Na+/K+ ATPase, vGlut1 and vGlut2 immunoreactivity were not significantly different to the size of cough receptor neurons.

Regulation (immunoreactivity) of vGlut1 in neurons associated with cough

4) Confidence 0.01 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0.45 Pain Relevance 0.36

3 Na+/K+ ATPase, vGlut1 and vGlut2 immunoreactivity was not universally expressed by all neurons in the nodose ganglia (data not directly shown but can inferred from Fig 3).

Regulation (immunoreactivity) of vGlut1 in ganglia

5) Confidence 0.01 Published 2008 Journal Cough Section Body Doc Link PMC2586627 Disease Relevance 0 Pain Relevance 0

General Comments

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