INT129508

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 6.47
Pain Relevance 5.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cacna1a) DNA binding (Cacna1a) transmembrane transport (Cacna1a)
cytoplasm (Cacna1a) cell death (Cacna1a) nucleus (Cacna1a)
Anatomy Link Frequency
brain structures 1
nucleus 1
neutrophils 1
Cacna1a (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 256 100.00 Very High Very High Very High
Migraine 102 100.00 Very High Very High Very High
Neurotransmitter 7 100.00 Very High Very High Very High
long-term potentiation 150 99.96 Very High Very High Very High
qutenza 158 99.82 Very High Very High Very High
Inflammation 61 98.60 Very High Very High Very High
antagonist 39 96.00 Very High Very High Very High
fluoxetine 2 94.12 High High
gABA 11 93.88 High High
Glutamate 10 93.56 High High
Disease Link Frequency Relevance Heat
Headache 84 100.00 Very High Very High Very High
Migraine With Aura 47 100.00 Very High Very High Very High
Stress 41 100.00 Very High Very High Very High
Urological Neuroanatomy 14 100.00 Very High Very High Very High
Apoptosis 50 99.88 Very High Very High Very High
INFLAMMATION 65 98.60 Very High Very High Very High
Malignant Neoplastic Disease 19 98.60 Very High Very High Very High
Cluster Headache 39 98.04 Very High Very High Very High
Death 21 96.48 Very High Very High Very High
Channelopathies 5 94.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mutations in the encoding gene, CACNA1A, are thus likely to affect neurotransmitter release.
Localization (release) of CACNA1A associated with neurotransmitter
1) Confidence 0.74 Published 2005 Journal Neuroscience Section Abstract Doc Link 16111830 Disease Relevance 0.24 Pain Relevance 0.19
Does such negative genetic evidence imply that FHM is not a useful model for migraine etiology?
Localization (etiology) of FHM associated with migraine
2) Confidence 0.65 Published 2008 Journal J Headache Pain Section Body Doc Link PMC2276243 Disease Relevance 2.08 Pain Relevance 1.26
During apoptosis, the La antigen translocates from nucleus to cytoplasm [30], and is fixed in dying cells by transglutaminase 2 (TG2) [29].
Localization (translocates) of La in nucleus associated with apoptosis
3) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645692 Disease Relevance 1.49 Pain Relevance 0
We did not find capsaicin-induced changes in presynaptic neurotransmitter release in the LA as compared to data obtained in other brain structures [52], [53].
Localization (release) of LA in brain structures associated with neurotransmitter, qutenza and amygdala
4) Confidence 0.08 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0.17 Pain Relevance 1.63
NO and CB1 receptors are involved in mediating capsaicin-induced reduction of LA-LTP
Localization (reduction) of LA associated with qutenza, long-term potentiation and amygdala
5) Confidence 0.07 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.41
More recently, it has been shown that this polymorphism is triallelic, with the l allele having two forms, lG and lA, resulting from a common G?
Localization (resulting) of lA
6) Confidence 0.05 Published 2010 Journal BMC Psychiatry Section Body Doc Link PMC2905344 Disease Relevance 0.28 Pain Relevance 0.06
Besides, the activity of LA on the MPO release from human neutrophils was also evaluated.
Localization (release) of LA in neutrophils associated with urological neuroanatomy
7) Confidence 0.04 Published 2010 Journal J Inflamm (Lond) Section Body Doc Link PMC3019217 Disease Relevance 0.84 Pain Relevance 0.37
levels in Tg2576 mice [79] and stress-induced corticosterone release in APPswe mice [81].
Localization (release) of Tg2576 associated with stress
8) Confidence 0.01 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 1.38 Pain Relevance 0.21

General Comments

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