INT12951

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Context Info
Confidence 0.57
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 126
Total Number 128
Disease Relevance 64.39
Pain Relevance 20.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 19
plasma 6
brain 5
kidney 3
blood 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 100.00 Very High Very High Very High
Sciatic nerve 8 99.98 Very High Very High Very High
Prostatitis 33 99.96 Very High Very High Very High
spinal inflammation 2 99.92 Very High Very High Very High
dexamethasone 10 99.88 Very High Very High Very High
diclofenac 19 99.86 Very High Very High Very High
Paracetamol 119 99.46 Very High Very High Very High
diabetic neuropathy 41 99.24 Very High Very High Very High
antagonist 9 99.16 Very High Very High Very High
Angina 8 99.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 6 100.00 Very High Very High Very High
Low Back Pain 4 100.00 Very High Very High Very High
Hip Osteoarthritis 2 100.00 Very High Very High Very High
Prostatitis 33 99.96 Very High Very High Very High
Stress 776 99.86 Very High Very High Very High
Hepatotoxicity 138 99.80 Very High Very High Very High
Urological Neuroanatomy 281 99.70 Very High Very High Very High
Diabetes Mellitus 949 99.68 Very High Very High Very High
Body Weight 644 99.68 Very High Very High Very High
Apoptosis 158 99.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, it is suggested that exercise-induced oxidative stress did not affect the catalase activities in trained group while exercise-induced oxidative stress led a decrease in plasma catalase activities in non-trained group.
Negative_regulation (decrease) of catalase in plasma associated with stress
1) Confidence 0.57 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2882571 Disease Relevance 0.40 Pain Relevance 0
The activity of H2O2 scavenging enzyme CAT is also decreased significantly after isoniazid treatment.
Negative_regulation (decreased) of CAT
2) Confidence 0.57 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2991701 Disease Relevance 0.43 Pain Relevance 0.06
Dexamethasone also reduced forskolin-stimulated CAT mRNA levels in C6 cells stably transfected with proenkephalin/CAT chimeric genes in the presence or absence of proteins synthesis.
Negative_regulation (reduced) of CAT associated with dexamethasone
3) Confidence 0.57 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.13 Pain Relevance 0.23
There was a significant decrease in CAT levels in DOX + TMZ + NAP group as compared to DOX group (P < 0.05) [Table 3].
Negative_regulation (decrease) of CAT
4) Confidence 0.57 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0 Pain Relevance 0
Myocardial CAT: In the DOX group, there was a significant decrease in CAT level compared to normal CTR group (P < 0.001).
Negative_regulation (decrease) of CAT
5) Confidence 0.57 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0 Pain Relevance 0
Bilateral transection of the sciatic nerve reduced CAT activity in the ventral horn of lumbar spinal cord, whereas CAT activity in the dorsal horn remained unchanged.
Negative_regulation (reduced) of CAT in spinal cord associated with dorsal horn, sciatic nerve and spinal cord
6) Confidence 0.57 Published 1986 Journal J. Neural Transm. Section Abstract Doc Link 3746289 Disease Relevance 0 Pain Relevance 0.45
APAP administration produced a decrease in hepatic SOD, CAT, and GSH-Px activities, and coadministration of erdosteine (150 and 300 mg/kg) resulted in increases in the activities.
Negative_regulation (decrease) of CAT associated with paracetamol
7) Confidence 0.57 Published 2008 Journal Toxicol Pathol Section Abstract Doc Link 18648099 Disease Relevance 0.22 Pain Relevance 0.63
It was associated with significant (P<0.05) rise in lipid peroxide level and decrease in superoxide dismutase and catalase activities in liver and kidneys.
Negative_regulation (decrease) of catalase in liver
8) Confidence 0.56 Published 2005 Journal Toxicology Section Abstract Doc Link 15863245 Disease Relevance 0.45 Pain Relevance 0.09
A significant decrease in the activity of anti-oxidant enzymes (superoxide dismutase and catalase) and an increase in lipid peroxidation were observed in sciatic nerves from diabetic rats compared with age-matched control rats.
Negative_regulation (decrease) of catalase in sciatic nerves associated with diabetes mellitus and sciatic nerve
9) Confidence 0.56 Published 2006 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 17042909 Disease Relevance 1.58 Pain Relevance 0.56
Inhibition of endogenous catalase activity by pretreatment with aminotriazole did not affect acetaminophen-induced cellular damage.
Negative_regulation (Inhibition) of catalase associated with paracetamol
10) Confidence 0.55 Published 1994 Journal Dig. Dis. Sci. Section Abstract Doc Link 8200258 Disease Relevance 0.07 Pain Relevance 0.72
MCAO led to significant rise in infarct size and lipid peroxidation, and depletion in glutathione content, superoxide dismutase and catalase activity in brain.
Negative_regulation (depletion) of catalase in brain
11) Confidence 0.54 Published 2010 Journal J Ethnopharmacol Section Body Doc Link 20435123 Disease Relevance 0.08 Pain Relevance 0
Mepirizole (300 mg/kg) increased the activities of FAOS and CAT about 2-fold, whereas the activities of catalase and urate oxidase and serum triglyceride level were decreased.
Negative_regulation (decreased) of catalase
12) Confidence 0.54 Published 1985 Journal J. Pharmacobio-dyn. Section Abstract Doc Link 3834060 Disease Relevance 0.13 Pain Relevance 0.22
Catalase activity was statistically decreased after both doses of nimesulid and acetylsalicylic acid at the dose of 10 mg/kg body weight.
Negative_regulation (decreased) of Catalase in body associated with aspirin and body weight
13) Confidence 0.53 Published 2006 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 17274466 Disease Relevance 0.52 Pain Relevance 0.45
Thus this plant provides protection by strengthening the antioxidants like reduced glutathione and catalase.
Negative_regulation (reduced) of catalase
14) Confidence 0.51 Published 2009 Journal Int J Vitam Nutr Res Section Abstract Doc Link 19839003 Disease Relevance 0.38 Pain Relevance 0.06
CCl4-induced generation of peroxy radicals and O2-• leads to inactivation of catalase and SOD.
Negative_regulation (inactivation) of catalase
15) Confidence 0.46 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.56 Pain Relevance 0
Pretreatment with the catalase inhibitor, 3-amino-1,2,4-triazole (AT), shows an attenuation of this ethanol-induced CTA.
Negative_regulation (inhibitor) of catalase associated with appetite loss
16) Confidence 0.43 Published 1985 Journal Life Sci. Section Abstract Doc Link 2999539 Disease Relevance 0.71 Pain Relevance 0.07
Catalase activities of trained group were significantly lower before exercise but higher during and after exercise than those of non-trained group because catalase activities of non-trained group were significantly decreased while those of trained group were not changed during and after exercise.
Negative_regulation (decreased) of catalase
17) Confidence 0.42 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2882571 Disease Relevance 0.46 Pain Relevance 0
The reduced activity of superoxide dismutase and catalase in the liver and kidney observed during diabetes may result in deleterious effects as a result of the accumulation of superoxide anion radicals and hydrogen peroxide (40).
Negative_regulation (reduced) of catalase in kidney associated with diabetes mellitus
18) Confidence 0.42 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.49 Pain Relevance 0
A significant increase in MDA and decreases in GSH level and GSH-Px, CAT, and SOD activity indicated that APAP-induced renal damage was mediated through oxidative stress.
Negative_regulation (decreases) of CAT associated with stress and paracetamol
19) Confidence 0.42 Published 2009 Journal Int Urol Nephrol Section Abstract Doc Link 19117117 Disease Relevance 0.69 Pain Relevance 1.09
Also a significant (p<0.001) reduction in the activities of glutathione dependent antioxidant enzymes (GPx and GST) and antiperoxidative enzymes (SOD and CAT) was observed.
Negative_regulation (reduction) of CAT
20) Confidence 0.42 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2291504 Disease Relevance 0.20 Pain Relevance 0

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