INT12952

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Context Info
Confidence 0.57
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 7.44
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cat) mitochondrion (Cat) aging (Cat)
Golgi apparatus (Cat) endoplasmic reticulum (Cat) plasma membrane (Cat)
Anatomy Link Frequency
liver 5
heart 3
neuronal 2
brain 2
kidney 2
Cat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 6 99.98 Very High Very High Very High
antagonist 18 99.70 Very High Very High Very High
B1 receptor 91 99.48 Very High Very High Very High
Paracetamol 8 98.64 Very High Very High Very High
Dopamine 9 85.28 High High
Bioavailability 12 84.68 Quite High
Serotonin 9 82.96 Quite High
adenocard 2 75.00 Quite High
allodynia 21 58.76 Quite High
Inflammation 41 55.48 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 77 100.00 Very High Very High Very High
Death 63 99.60 Very High Very High Very High
Stress 195 99.54 Very High Very High Very High
Poisoning 8 99.06 Very High Very High Very High
Diabetes Mellitus 290 96.28 Very High Very High Very High
Body Weight 26 90.88 High High
Hepatotoxicity 13 86.56 High High
Drug-induced Liver Injury 4 86.24 High High
Hypothermia 6 84.96 Quite High
Congenital Anomalies 5 80.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone reduced forskolin-stimulated CAT expression from plasmids with 190 or more base-pairs of 5'-flanking sequence, an effect apparently involving multiple up-stream regions.
Negative_regulation (reduced) of Gene_expression (expression) of CAT associated with dexamethasone
1) Confidence 0.57 Published 1991 Journal Mol. Endocrinol. Section Abstract Doc Link 1658636 Disease Relevance 0.14 Pain Relevance 0.24
There was also a significant decrease in CAT levels in NAP PS group (P < 0.001), but no significant difference in cardiac tissue CAT levels was observed in TMZ PS group (P > 0.05) as compared to normal CTR group.
Negative_regulation (decrease) of Gene_expression (levels) of CAT
2) Confidence 0.57 Published 2010 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2885640 Disease Relevance 0 Pain Relevance 0
The rats intoxicated with acetaminophen showed significant elevation in the levels of lipid peroxides with decreased levels of protein, GSH, SOD, CAT and impaired tricarboxylic acid cycle enzyme activities.
Negative_regulation (decreased) of Gene_expression (levels) of CAT associated with paracetamol
3) Confidence 0.41 Published 2005 Journal Chemosphere Section Abstract Doc Link 16168751 Disease Relevance 0.24 Pain Relevance 0.34
The observed decrease in oxidative stress was due to the better maintained CAT activity and increased SOD levels on attaining Trec 23°C and on recovery of Trec 37°C.
Negative_regulation (maintained) of Gene_expression (levels) of CAT associated with stress
4) Confidence 0.41 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1062147 Disease Relevance 0.80 Pain Relevance 0
Assay of glutathione reductase and catalase activity
Negative_regulation (Assay) of Gene_expression (activity) of catalase
5) Confidence 0.35 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2600521 Disease Relevance 0 Pain Relevance 0
We too observed that CCl4 challenge significantly decreased the levels of SOD and catalase in liver and kidney.
Negative_regulation (decreased) of Gene_expression (levels) of catalase in liver
6) Confidence 0.34 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.56 Pain Relevance 0
Recently, Szymonik-Lesiuk et al [2] have shown that CCl4 intoxication can lead to alteration in gene expression and depletion of SOD and catalase levels in kidney and heart.
Negative_regulation (depletion) of Gene_expression (levels) of catalase in heart associated with poisoning
7) Confidence 0.34 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.50 Pain Relevance 0
In contrast, vasodilation of arteries from HSD rats was impaired at only high doses of ACh which likewise demonstrated improved vasodilation in the presence of tiron and catalase but not EUK-134 (Figure 4).
Negative_regulation (impaired) of Gene_expression (doses) of catalase associated with increased venous pressure under development
8) Confidence 0.32 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2887873 Disease Relevance 1.27 Pain Relevance 0.04
Assay of catalase activity
Negative_regulation (Assay) of Gene_expression (activity) of catalase
9) Confidence 0.27 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2386505 Disease Relevance 0 Pain Relevance 0
AZL also reduced the levels of catalase indicating a reduction in the accumulation of reactive oxygen species.
Negative_regulation (reduced) of Gene_expression (levels) of catalase
10) Confidence 0.23 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.64 Pain Relevance 0.03
Similarly, erythrocyte catalase levels were diminished without a significant change in the liver catalase levels.
Negative_regulation (diminished) of Gene_expression (levels) of erythrocyte catalase in liver
11) Confidence 0.20 Published 2010 Journal Experimental Diabetes Research Section Body Doc Link PMC3014714 Disease Relevance 0.49 Pain Relevance 0.03
It is therefore logical that the reduction of the oxidative stress by chronic treatment with B1R antagonist resulted in a normalization of the MnSOD and catalase expression.
Negative_regulation (normalization) of Gene_expression (expression) of catalase associated with stress, antagonist and b1 receptor
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935380 Disease Relevance 0.80 Pain Relevance 0.39
We too observed that CCl4 challenge significantly decreased the levels of SOD and catalase in liver and kidney.
Negative_regulation (decreased) of in kidney Gene_expression (levels) of catalase in liver
13) Confidence 0.11 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.56 Pain Relevance 0
Recently, Szymonik-Lesiuk et al [2] have shown that CCl4 intoxication can lead to alteration in gene expression and depletion of SOD and catalase levels in kidney and heart.
Negative_regulation (depletion) of in kidney Gene_expression (levels) of catalase in heart associated with poisoning
14) Confidence 0.11 Published 2005 Journal BMC Pharmacol Section Body Doc Link PMC549532 Disease Relevance 0.50 Pain Relevance 0
Moreover, chronic administration of haloperidol resulted in increased lipid peroxidation, decreased reduced glutathione, superoxide dismutase and catalase levels in different regions of brain which was reversed by pretreatment with curcumin.
Negative_regulation (decreased) of Gene_expression (levels) of catalase in brain
15) Confidence 0.08 Published 2010 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2929771 Disease Relevance 0.24 Pain Relevance 0.08
The ability of catalase to inhibit neuronal death in AdAcon to a greater extent than AdGFP transduced cells, suggests that in addition to the intracellular mechanism (i.e.
Negative_regulation (inhibit) of Gene_expression (ability) of catalase in neuronal associated with death
16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2738973 Disease Relevance 0.71 Pain Relevance 0

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