INT129534

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 23.68
Pain Relevance 1.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Nppb) extracellular region (Nppb) nucleus (Nppb)
cytoplasm (Nppb)
Anatomy Link Frequency
plasma 3
cardiomyocyte 3
coronary artery 1
brain 1
heart 1
Nppb (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 9 98.12 Very High Very High Very High
antagonist 13 96.24 Very High Very High Very High
anesthesia 4 92.52 High High
fibrosis 115 87.32 High High
cva 6 83.12 Quite High
Angina 46 82.92 Quite High
Inflammation 39 82.64 Quite High
metalloproteinase 3 80.20 Quite High
imagery 7 79.48 Quite High
chemokine 1 75.28 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 59 100.00 Very High Very High Very High
Mitral Valve Insufficiency 317 99.98 Very High Very High Very High
Urological Neuroanatomy 40 99.92 Very High Very High Very High
Acute Coronary Syndrome 124 99.84 Very High Very High Very High
Body Weight 7 99.60 Very High Very High Very High
Sickle Cell Anemia 108 99.36 Very High Very High Very High
Thalassemia 100 98.92 Very High Very High Very High
Muscular Dystrophy 140 98.76 Very High Very High Very High
Hypertension 274 98.64 Very High Very High Very High
Heart Rate Under Development 118 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No relationship was found between high levels of BNP and coronary events during the follow-up.
Gene_expression (levels) of BNP
1) Confidence 0.58 Published 2009 Journal Med Clin (Barc) Section Body Doc Link 19783260 Disease Relevance 0.08 Pain Relevance 0
Recently, a relationship between circulating levels of BNP and NT-proBNP and long-term all cause mortality in patients with stable coronary artery disease has been documented.
Gene_expression (levels) of BNP in coronary artery associated with cardiovascular disease
2) Confidence 0.46 Published 2005 Journal Scand. J. Clin. Lab. Invest. Suppl. Section Abstract Doc Link 16112956 Disease Relevance 1.41 Pain Relevance 0.22
Amino-terminal pro-brain natriuretic peptide
Gene_expression (pro) of brain natriuretic peptide in brain associated with natriuresis
3) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.63 Pain Relevance 0
High levels of brain natriuretic peptide (BNP) reflect cardiac volume and pressure afterload as this hormone is released in response to cardiomyocyte stretching.
Gene_expression (levels) of brain natriuretic peptide in cardiomyocyte associated with natriuresis
4) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.56 Pain Relevance 0
Machado et al. [24] found that amino-terminal proBNP levels were higher in SCD patients with PH and correlated directly with TRV (R = 0.5, P < 0.001).
Gene_expression (levels) of proBNP associated with sickle cell anemia and hypertension
5) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.38 Pain Relevance 0
High levels of brain natriuretic peptide (BNP) reflect cardiac volume and pressure afterload as this hormone is released in response to cardiomyocyte stretching.
Gene_expression (levels) of BNP in cardiomyocyte associated with natriuresis
6) Confidence 0.46 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2948405 Disease Relevance 2.57 Pain Relevance 0
MEASUREMENTS AND MAIN RESULTS: Two levels of BNP were evaluated: the median (BNP >133 pg/mL) and a cutoff (BNP >82 pg/mL) based on receiver-operating characteristic (ROC) analysis.
Gene_expression (levels) of BNP
7) Confidence 0.44 Published 2009 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 19167912 Disease Relevance 0 Pain Relevance 0
In DMD, patients that were not on mechanical ventilation the plasma levels of BNP were associated with systolic dysfunction [36].
Gene_expression (levels) of BNP in plasma associated with muscular dystrophy
8) Confidence 0.37 Published 2010 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC3024556 Disease Relevance 0.76 Pain Relevance 0.14
Pioglitazone treatment increased heart–to–body weight ratios and cardiac BNP mRNA expression in AngII-infused mice but did not alter SBP, cardiomyocyte diameters, or ventricular ANP mRNA expression (Table 1, two-way ANOVA).
Gene_expression (expression) of BNP mRNA in cardiomyocyte associated with body weight
9) Confidence 0.33 Published 2008 Journal Diabetes Section Body Doc Link PMC2518499 Disease Relevance 0.78 Pain Relevance 0.25
Indeed, in the current study we show for the first time that the prognostic information obtained from MR grade and BNP in ACS is complementary and significant when LVEF is also considered.
Gene_expression (grade) of BNP associated with acute coronary syndrome and mitral valve insufficiency
10) Confidence 0.33 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 1.74 Pain Relevance 0
Ninety patients (12%) had an MR grade >1, 110 patients (15%) had an LVEF <0.40 and 180 patients (25%) had BNP levels above the 75th percentile (373?
Gene_expression (levels) of BNP associated with mitral valve insufficiency
11) Confidence 0.33 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 1.41 Pain Relevance 0.22
Furthermore, when MR, LVEF and BNP were forced into the same model together with clinical variables (multivariate model 3), all three factors remained significantly associated with long-term mortality (HR for MR 1.53 (95% CI 1.06 to 2.19), p=0.02; HR for LVEF 1.94 (95% CI 1.38 to 2.73), p=0.0001; and HR for BNP 1.45 (95% CI 1.06 to 1.99), p=0.02, table 2).
Gene_expression (forced) of BNP associated with mitral valve insufficiency
12) Confidence 0.30 Published 2010 Journal Heart Section Body Doc Link PMC2976074 Disease Relevance 1.34 Pain Relevance 0.06
Long-term follow-up in a prospective ACS cohort with Doppler-assessed MR, echocardiographically-determined LVEF and plasma BNP levels by ELISA.


Spec (determined) Gene_expression (levels) of BNP in plasma associated with acute coronary syndrome and mitral valve insufficiency
13) Confidence 0.30 Published 2010 Journal Heart Section Abstract Doc Link PMC2976074 Disease Relevance 1.36 Pain Relevance 0
Furthermore, anemic patients were more likely to have elevated N-terminal fragment levels of the B-type natriuretic peptide (NT-proBNP) in the progressed group (P=0.036).


Gene_expression (levels) of B-type natriuretic peptide associated with natriuresis
14) Confidence 0.22 Published 2010 Journal Korean Journal of Pediatrics Section Abstract Doc Link PMC3004486 Disease Relevance 0.51 Pain Relevance 0
Furthermore, anemic patients were more likely to have elevated N-terminal fragment levels of the B-type natriuretic peptide (NT-proBNP) in the progressed group (P=0.036).


Gene_expression (levels) of NT-proBNP associated with natriuresis
15) Confidence 0.19 Published 2010 Journal Korean Journal of Pediatrics Section Abstract Doc Link PMC3004486 Disease Relevance 0.51 Pain Relevance 0
Levels of BNP are used to facilitate the diagnosis of heart failure and to determine the prognosis in patients with heart failure and myocardial infarction in adults27-29).
Gene_expression (Levels) of BNP in heart associated with heart rate under development and myocardial infarction
16) Confidence 0.19 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004486 Disease Relevance 1.21 Pain Relevance 0.04
The major finding of this study is the demonstration that the decreased serum levels of TRAIL, measured within 24 hours after AMI (baseline), were inversely correlated with important prognostic markers for adverse cardiovascular events, such as circulating levels of CK, CK-MB and BNP.
Gene_expression (levels) of BNP associated with myocardial infarction
17) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2637972 Disease Relevance 0.46 Pain Relevance 0.12
Hemodynamics, the incidence of electrocardiographic abnormality, and levels of B-type natriuretic peptide, troponin T, S-100beta, 8-Hydroxy-2'-deoxyguanosine, interleukin-6 (IL-6), and IL-1 receptor antagonist were compared.
Gene_expression (levels) of B-type natriuretic peptide associated with natriuresis and antagonist
18) Confidence 0.10 Published 2010 Journal J Neurosurg Anesthesiol Section Abstract Doc Link 20118792 Disease Relevance 1.28 Pain Relevance 0.50
Plasma levels of NT-proBNP, MPO and PR3–SERPIN A1 were normalized by log-transformation.
Gene_expression (levels) of NT-proBNP in Plasma associated with urological neuroanatomy
19) Confidence 0.10 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.40 Pain Relevance 0
Samples or NT-proBNP standards (10 ?
Gene_expression (standards) of NT-proBNP
20) Confidence 0.08 Published 2010 Journal Clinical Science (London, England : 1979) Section Body Doc Link PMC2999885 Disease Relevance 0.30 Pain Relevance 0.06

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