INT129577

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Context Info
Confidence 0.29
First Reported 2004
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.45
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry2) aging (P2ry2) plasma membrane (P2ry2)
embryo development (P2ry2) lysosome (P2ry2) signal transducer activity (P2ry2)
Anatomy Link Frequency
chromaffin cells 2
dorsal horn 2
hippocampus 2
P2ry2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 10 100.00 Very High Very High Very High
spinal dorsal horn 15 99.92 Very High Very High Very High
Hippocampus 17 97.60 Very High Very High Very High
Glutamate 16 91.92 High High
agonist 30 91.04 High High
qutenza 84 89.80 High High
Pyramidal cell 2 81.80 Quite High
Root ganglion neuron 5 76.08 Quite High
Central nervous system 14 73.52 Quite High
Dorsal horn 20 64.80 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 12 89.52 High High
Neurodegenerative Disease 13 81.76 Quite High
Ganglion Cysts 9 75.68 Quite High
Fever 12 75.24 Quite High
Death 5 62.96 Quite High
Depression 7 50.00 Quite Low
Apoptosis 4 44.04 Quite Low
Targeted Disruption 7 10.16 Low Low
Disease 11 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, ATP was found to directly inhibit NMDA receptors independently of G proteins and, therefore, not by activation of P2Y receptors.
Negative_regulation (inhibit) of Neg (not) Positive_regulation (activation) of P2Y associated with nmda receptor
1) Confidence 0.29 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096562 Disease Relevance 0.08 Pain Relevance 0.47
Here we show that ATP receptor activation reduces secretion downstream from cytosolic Ca2+ elevation in rat adrenal chromaffin cells.
Negative_regulation (reduces) of Positive_regulation (activation) of ATP receptor in chromaffin cells
2) Confidence 0.26 Published 2005 Journal Nat. Neurosci. Section Abstract Doc Link 16116443 Disease Relevance 0.09 Pain Relevance 0.06
There was a marked decrease in the concentration of mRNA coding for P2Y1 receptors and upregulation of mRNA transcription coding for P2Y2 receptors in freshly isolated astrocytes of developing rat hippocampus [57].


Negative_regulation (decrease) of Positive_regulation (upregulation) of P2Y2 in hippocampus associated with hippocampus
3) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.21 Pain Relevance 0.09
These results indicate that the threshold for activation of TRPV1 channels in the spinal dorsal horn is decreased by the activation of the P2Y receptor.
Negative_regulation (decreased) of Positive_regulation (activation) of P2Y receptor in dorsal horn associated with spinal dorsal horn
4) Confidence 0.03 Published 2006 Journal Mol Pain Section Body Doc Link PMC1434724 Disease Relevance 0.08 Pain Relevance 0.38

General Comments

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