INT129585

Context Info Confidence 0.59 First Reported 2005 Last Reported 2010 Negated 3 Speculated 1 Reported most in Body Documents 17 Total Number 19 Disease Relevance 4.46 Pain Relevance 9.30

unfolded protein binding (St13) protein folding (St13) cytosol (St13) protein complex (St13) cytoplasm (St13)

Anatomy Link Frequency neurons 4 liver 2 substantia nigra pars compacta 2 peritoneum 1 tail 1 St13 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 361 100.00 Substantia nigra 66 100.00 opioid receptor 58 100.00 Morphine 28 100.00 antinociception 15 100.00 antagonist 11 100.00 Antinociceptive 6 99.98 Dopamine 192 99.96 Ventral tegmentum 8 99.80 ischemia 4 99.48

Disease Link Frequency Relevance Heat Liver Cancer 2 99.84 Targeted Disruption 122 99.60 Coronary Artery Disease 2 99.48 Pain 92 99.44 Injury 8 98.92 Hyperalgesia 30 98.88 Disease 32 98.76 Parkinson's Disease 106 96.16 Death 46 95.48 Tremor 2 95.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear.

Gene_expression (overexpressed) of HIP/PAP in liver associated with liver cancer

1) Confidence 0.59 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.32 Pain Relevance 0.07

HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear.

Gene_expression (overexpressed) of HIP/PAP in liver associated with liver cancer

2) Confidence 0.51 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.32 Pain Relevance 0.07

No protection was produced by SNC in Cav-3 knockout mice.

Neg (No) Gene_expression (produced) of SNC associated with targeted disruption

3) Confidence 0.26 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.38 Pain Relevance 0.71

Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a ?

Gene_expression (presence) of SNC associated with targeted disruption, coronary artery disease and ischemia

4) Confidence 0.26 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20736437 Disease Relevance 0.37 Pain Relevance 0.68

FluoViewTM assessment of the pseudocolored Ser(P)-19 Cy5 signal (orange) confirmed significantly greater TH-Ser(P)-19 in GFP-transduced TH neurons (788 ± 34 pixels) compared with WT-Syn (404 ± 29 pixels)- or S129A-Syn-transduced SNc TH neurons (371 ± 18.5 pixels) (p < 0.0001, one-way ANOVA) (Fig. 6B, fifth panel).

Gene_expression (transduced) of SNc in neurons

5) Confidence 0.10 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.11

Hence, although both agonists showed similar pain relieving properties, only SNC80 produced DOR-eGFP internalization in vivo in both central and peripheral nervous systems.

Gene_expression (produced) of SNC80 in peripheral nervous systems associated with pain and agonist

6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.10 Pain Relevance 0.30

Considering this scenario, we observed that SNC80 but not ARM390 produced DOR-eGFP phosphorylation on the Ser363 site.

Neg (not) Gene_expression (produced) of SNC80

7) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.09

Both SNC80 and ARM390 produced similar levels of receptor stimulation, while Met-enkephalin was slightly more efficacious.

Gene_expression (produced) of SNC80 associated with enkephalin

8) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.69

SNC80 produced robust DOR-eGFP endocytosis, which was concomitant with an increase in receptor phosphorylation and a decrease in [35S]GTP?

Gene_expression (produced) of SNC80

9) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.06 Pain Relevance 0.24

Low magnification images near the site of the needle tract of lentivirally transduced ASKO mice revealed widespread expression of GFP or a-Syn around and within substantia nigra pars compacta (SNc) of mice transduced with GFP, WT-Syn, or S129A-Syn lentivirus (Fig. 6, A and B, left panels).

Gene_expression (expression) of SNc in substantia nigra pars compacta associated with substantia nigra

10) Confidence 0.09 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2878529 Disease Relevance 0 Pain Relevance 0.13

We analyzed opioid receptor expression in peritoneum by immunohistochemistry, antinociception after i.p. injected agonists at mu (morphine, loperamide)-, delta (SNC80)- and kappa (U50488)-receptors, and its reversibility by subcutaneously (s.c.) administered centrally penetrating antagonists beta-funaltrexamine (mu), naltrindole (delta) and nor-binaltorphimine (kappa), and by the peripherally restricted antagonist naloxone methiodide (NLXM).

Spec (analyzed) Gene_expression (expression) of SNC80 in peritoneum associated with antinociception, antagonist, narcan, agonist, opioid receptor and morphine

11) Confidence 0.09 Published 2007 Journal Brain Res. Section Abstract Doc Link 17599812 Disease Relevance 0.10 Pain Relevance 1.01

One cannot exclude the possibility that some recycling of DOR-eGFP occurred after SNC80 treatment, which was not detectable in our experimental conditions.

Neg (not) Gene_expression (detectable) of SNC80

12) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0 Pain Relevance 0.35

CFA in the paw or tail produced robust allodynic or hyperalgesic responses, which were completely reversed by the first injection of SNC80 or ARM390 (Figure 2D, Test 1).

Gene_expression (injection) of SNC80 in tail associated with hyperalgesia

13) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.49 Pain Relevance 0.49

According to the group assignment, mice were pretreated with a KOP antagonist, nor-binaltorphimine (nor-BNI), a DOP antagonist, naltrindole hydrochloride (NTI), a KOP agonist U50488, and a DOP agonist SNC80.

Gene_expression (pretreated) of SNC80 associated with antagonist, agonist and opioid receptor

14) Confidence 0.07 Published 2010 Journal J Anesth Section Abstract Doc Link 20157832 Disease Relevance 0.09 Pain Relevance 1.58

Antinociceptive response of DAMGO, SNC80, U50,488H, and oxycodone in tolerant mice treated with BMS182874 was significantly higher (44.55%, 37.48%, 43.02%, and 56.08%, respectively) compared to tolerant mice treated with vehicle.

Gene_expression (response) of SNC80 associated with oxycodone and antinociceptive

15) Confidence 0.07 Published 2010 Journal Eur. J. Pharmacol. Section Abstract Doc Link 20303944 Disease Relevance 0 Pain Relevance 2.32

The area of TH+ neurons in the SNc and VTA was estimated using the nucleator probe.

Gene_expression (neurons) of SNc in neurons associated with ventral tegmentum

16) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.08

Tyrosine Hydroxylase, TH-positive neurons) in the substantia nigra pars compacta (SNc) and to reproduce neuropathological features of PD in mice [35], [36].

Gene_expression (reproduce) of SNc in SNc associated with substantia nigra and disease

17) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2675062 Disease Relevance 0.93 Pain Relevance 0.05

5.1±0.3), consistent with increased transduction of TH neurons in the SNc (Figure 4).

Gene_expression (transduction) of SNc in neurons

18) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.18 Pain Relevance 0.13

These symptoms result primarily from progressive degeneration of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc).

Gene_expression (producing) of SNc in neurons associated with dopamine and substantia nigra

19) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2941453 Disease Relevance 0.99 Pain Relevance 0.19

General Comments

This test has worked.