INT129585
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear. | |||||||||||||||
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HIP/PAP is overexpressed in liver carcinoma; however, its functional role remains unclear. | |||||||||||||||
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No protection was produced by SNC in Cav-3 knockout mice. | |||||||||||||||
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Cav-3 overexpressing mice, Cav-3 knockout mice, and controls were exposed to myocardial ischemia/reperfusion (I/R) in the presence of SNC-121 (SNC), a ? | |||||||||||||||
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FluoViewTM assessment of the pseudocolored Ser(P)-19 Cy5 signal (orange) confirmed significantly greater TH-Ser(P)-19 in GFP-transduced TH neurons (788 ± 34 pixels) compared with WT-Syn (404 ± 29 pixels)- or S129A-Syn-transduced SNc TH neurons (371 ± 18.5 pixels) (p < 0.0001, one-way ANOVA) (Fig. 6B, fifth panel). | |||||||||||||||
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Hence, although both agonists showed similar pain relieving properties, only SNC80 produced DOR-eGFP internalization in vivo in both central and peripheral nervous systems. | |||||||||||||||
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Considering this scenario, we observed that SNC80 but not ARM390 produced DOR-eGFP phosphorylation on the Ser363 site. | |||||||||||||||
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Both SNC80 and ARM390 produced similar levels of receptor stimulation, while Met-enkephalin was slightly more efficacious. | |||||||||||||||
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SNC80 produced robust DOR-eGFP endocytosis, which was concomitant with an increase in receptor phosphorylation and a decrease in [35S]GTP? | |||||||||||||||
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Low magnification images near the site of the needle tract of lentivirally transduced ASKO mice revealed widespread expression of GFP or a-Syn around and within substantia nigra pars compacta (SNc) of mice transduced with GFP, WT-Syn, or S129A-Syn lentivirus (Fig. 6, A and B, left panels). | |||||||||||||||
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We analyzed opioid receptor expression in peritoneum by immunohistochemistry, antinociception after i.p. injected agonists at mu (morphine, loperamide)-, delta (SNC80)- and kappa (U50488)-receptors, and its reversibility by subcutaneously (s.c.) administered centrally penetrating antagonists beta-funaltrexamine (mu), naltrindole (delta) and nor-binaltorphimine (kappa), and by the peripherally restricted antagonist naloxone methiodide (NLXM). | |||||||||||||||
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One cannot exclude the possibility that some recycling of DOR-eGFP occurred after SNC80 treatment, which was not detectable in our experimental conditions. | |||||||||||||||
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CFA in the paw or tail produced robust allodynic or hyperalgesic responses, which were completely reversed by the first injection of SNC80 or ARM390 (Figure 2D, Test 1). | |||||||||||||||
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According to the group assignment, mice were pretreated with a KOP antagonist, nor-binaltorphimine (nor-BNI), a DOP antagonist, naltrindole hydrochloride (NTI), a KOP agonist U50488, and a DOP agonist SNC80. | |||||||||||||||
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Antinociceptive response of DAMGO, SNC80, U50,488H, and oxycodone in tolerant mice treated with BMS182874 was significantly higher (44.55%, 37.48%, 43.02%, and 56.08%, respectively) compared to tolerant mice treated with vehicle. | |||||||||||||||
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The area of TH+ neurons in the SNc and VTA was estimated using the nucleator probe. | |||||||||||||||
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Tyrosine Hydroxylase, TH-positive neurons) in the substantia nigra pars compacta (SNc) and to reproduce neuropathological features of PD in mice [35], [36]. | |||||||||||||||
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5.1±0.3), consistent with increased transduction of TH neurons in the SNc (Figure 4).
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These symptoms result primarily from progressive degeneration of dopamine (DA) producing neurons in the substantia nigra pars compacta (SNc). | |||||||||||||||
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General Comments
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