INT129587

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Context Info
Confidence 0.86
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.41
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Tnf) signal transduction (Tnf) extracellular space (Tnf)
extracellular region (Tnf) plasma membrane (Tnf) intracellular (Tnf)
Anatomy Link Frequency
liver 1
PC-3 1
Tnf (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 12 99.78 Very High Very High Very High
Paracetamol 3 84.96 Quite High
Disease Link Frequency Relevance Heat
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Targeted Disruption 4 99.10 Very High Very High Very High
Severe Combined Immunodeficiency 1 83.52 Quite High
Hepatitis 1 82.40 Quite High
Reprotox - General 1 5 75.12 Quite High
Injury 1 75.00 Quite High
Apoptosis 1 71.40 Quite High
Liver Cancer 1 68.84 Quite High
Overdose 1 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In further studies, capsaicin inhibited tumor necrosis factor-alpha-stimulated degradation of IkappaBalpha in PC-3 cells, which was associated with the inhibition of proteasome activity.
Protein_catabolism (degradation) of tumor necrosis factor in PC-3 associated with necrosis, qutenza and cancer
1) Confidence 0.86 Published 2006 Journal Cancer Res. Section Abstract Doc Link 16540674 Disease Relevance 0.57 Pain Relevance 0.87
Comparison of the early events posthepatectomy in control and transgenic mice indicated that HIP/PAP accelerates the accumulation/degradation of nuclear phospho-signal transducer activator transcription factor 3 and tumor necrosis factor alpha level, thus reflecting that HIP/PAP accelerates liver regeneration.
Protein_catabolism (accumulation/degradation) of tumor necrosis factor alpha in liver associated with targeted disruption, necrosis and cancer
2) Confidence 0.17 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.84 Pain Relevance 0.21

General Comments

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