INT129589

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 3.00
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (St13) protein folding (St13) cytosol (St13)
protein complex (St13) cytoplasm (St13)
Anatomy Link Frequency
liver 2
neurons 1
pancreas 1
striatum 1
St13 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 460 100.00 Very High Very High Very High
Ventral tegmentum 32 99.80 Very High Very High Very High
Dynorphin 24 99.28 Very High Very High Very High
Kappa opioid receptor 4 97.88 Very High Very High Very High
Pain 28 96.48 Very High Very High Very High
midbrain 60 96.08 Very High Very High Very High
agonist 116 95.56 Very High Very High Very High
Hyperalgesia 4 88.84 High High
allodynia 8 86.48 High High
Eae 28 82.44 Quite High
Disease Link Frequency Relevance Heat
Severe Combined Immunodeficiency 3 97.52 Very High Very High Very High
Pain 30 96.48 Very High Very High Very High
Targeted Disruption 48 93.72 High High
Injury 7 91.16 High High
Apoptosis 40 90.72 High High
Liver Cancer 3 90.24 High High
Hyperalgesia 10 88.84 High High
Neuropathic Pain 8 86.48 High High
Disease 20 85.12 High High
Death 36 72.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein HIP/PAP is a secreted C-type lectin belonging to group VII, according to Drickamer's classification.
Positive_regulation (hepatocarcinoma-intestine-pancreas/pancreatic-associated) of HIP/PAP in pancreas
1) Confidence 0.38 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.30 Pain Relevance 0.07
After a single injection of HIP/PAP protein, the percentages of bromodeoxyuridine-positive nuclei and mitosis were statistically higher than after saline injection, indicating that HIP/PAP acts as a paracrine mitogenic growth factor for the liver.
Positive_regulation (injection) of HIP/PAP in liver
2) Confidence 0.38 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.61 Pain Relevance 0.07
After a single injection of HIP/PAP protein, the percentages of bromodeoxyuridine-positive nuclei and mitosis were statistically higher than after saline injection, indicating that HIP/PAP acts as a paracrine mitogenic growth factor for the liver.
Positive_regulation (injection) of HIP/PAP in liver
3) Confidence 0.38 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.61 Pain Relevance 0.07
However, a subsequent injection of SNC80 or ARM390 produced distinct responses.
Positive_regulation (injection) of SNC80
4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.80 Pain Relevance 0.78
This compound is a derivative of SNC80, and has a higher selectivity for delta over mu and kappa opioid receptors [22].
Positive_regulation (derivative) of SNC80 associated with kappa opioid receptor
5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.25
Increased DRD1 and dynorphin levels in medium spiny neurons may enhance the inhibition of DA neurons in the SNc, thereby normalizing overall DA release in the striatum.


Spec (may) Positive_regulation (enhance) of SNc in striatum associated with dopamine and dynorphin
6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.09 Pain Relevance 0.37
The authors reported a significant increase in cell size and number of TH positive profiles in the SNc on the injected side.
Positive_regulation (increase) of SNc
7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.37 Pain Relevance 0.27
Four weeks after the lesion, control 6OHDA-treated mice showed an extensive loss of TH positive SNc neurons in the ipsilateral or lesioned nigral region (Fig. 8A and B).
Positive_regulation (neurons) of SNc in neurons
8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.44
4) induced a significant increase in SNc and VTA total volume (Fig. 2A and B; Fig. 3A) as compared to controls (n?
Positive_regulation (increase) of SNc associated with ventral tegmentum
9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.27

General Comments

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