INT129589

Context Info Confidence 0.38 First Reported 2005 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 9 Disease Relevance 3.00 Pain Relevance 2.61

unfolded protein binding (St13) protein folding (St13) cytosol (St13) protein complex (St13) cytoplasm (St13)

Anatomy Link Frequency liver 2 neurons 1 pancreas 1 striatum 1 St13 (Mus musculus)

Pain Link Frequency Relevance Heat Dopamine 460 100.00 Ventral tegmentum 32 99.80 Dynorphin 24 99.28 Kappa opioid receptor 4 97.88 Pain 28 96.48 midbrain 60 96.08 agonist 116 95.56 Hyperalgesia 4 88.84 allodynia 8 86.48 Eae 28 82.44

Disease Link Frequency Relevance Heat Severe Combined Immunodeficiency 3 97.52 Pain 30 96.48 Targeted Disruption 48 93.72 Injury 7 91.16 Apoptosis 40 90.72 Liver Cancer 3 90.24 Hyperalgesia 10 88.84 Neuropathic Pain 8 86.48 Disease 20 85.12 Death 36 72.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Human hepatocarcinoma-intestine-pancreas/pancreatic-associated protein HIP/PAP is a secreted C-type lectin belonging to group VII, according to Drickamer's classification.

Positive_regulation (hepatocarcinoma-intestine-pancreas/pancreatic-associated) of HIP/PAP in pancreas

1) Confidence 0.38 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.30 Pain Relevance 0.07

After a single injection of HIP/PAP protein, the percentages of bromodeoxyuridine-positive nuclei and mitosis were statistically higher than after saline injection, indicating that HIP/PAP acts as a paracrine mitogenic growth factor for the liver.

Positive_regulation (injection) of HIP/PAP in liver

2) Confidence 0.38 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.61 Pain Relevance 0.07

After a single injection of HIP/PAP protein, the percentages of bromodeoxyuridine-positive nuclei and mitosis were statistically higher than after saline injection, indicating that HIP/PAP acts as a paracrine mitogenic growth factor for the liver.

Positive_regulation (injection) of HIP/PAP in liver

3) Confidence 0.38 Published 2005 Journal Hepatology Section Abstract Doc Link 16116631 Disease Relevance 0.61 Pain Relevance 0.07

However, a subsequent injection of SNC80 or ARM390 produced distinct responses.

Positive_regulation (injection) of SNC80

4) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.80 Pain Relevance 0.78

This compound is a derivative of SNC80, and has a higher selectivity for delta over mu and kappa opioid receptors [22].

Positive_regulation (derivative) of SNC80 associated with kappa opioid receptor

5) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2672171 Disease Relevance 0.07 Pain Relevance 0.25

Increased DRD1 and dynorphin levels in medium spiny neurons may enhance the inhibition of DA neurons in the SNc, thereby normalizing overall DA release in the striatum.

Spec (may) Positive_regulation (enhance) of SNc in striatum associated with dopamine and dynorphin

6) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.09 Pain Relevance 0.37

The authors reported a significant increase in cell size and number of TH positive profiles in the SNc on the injected side.

Positive_regulation (increase) of SNc

7) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.37 Pain Relevance 0.27

Four weeks after the lesion, control 6OHDA-treated mice showed an extensive loss of TH positive SNc neurons in the ipsilateral or lesioned nigral region (Fig. 8A and B).

Positive_regulation (neurons) of SNc in neurons

8) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.44

4) induced a significant increase in SNc and VTA total volume (Fig. 2A and B; Fig. 3A) as compared to controls (n?

Positive_regulation (increase) of SNc associated with ventral tegmentum

9) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0.15 Pain Relevance 0.27

General Comments

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