INT129604

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.68
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SPINK4)
Anatomy Link Frequency
plasma 1
fat 1
SPINK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
antidepressant 1 99.20 Very High Very High Very High
tramadol 1 98.40 Very High Very High Very High
Serotonin 7 92.80 High High
noradrenaline 1 92.24 High High
Central nervous system 2 83.32 Quite High
Dopamine 1 76.40 Quite High
methadone 8 50.00 Quite Low
rapifen 3 25.00 Low Low
anesthesia 1 25.00 Low Low
Versed 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Weight Loss 109 96.20 Very High Very High Very High
Obesity 272 86.96 High High
Pressure And Volume Under Development 1 81.24 Quite High
Overweight 38 36.20 Quite Low
Diabetes Mellitus 29 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 16 5.00 Very Low Very Low Very Low
Hypertension 15 5.00 Very Low Very Low Very Low
Insulin Resistance 14 5.00 Very Low Very Low Very Low
Body Weight 14 5.00 Very Low Very Low Very Low
Abdominal Obesity 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The drug orlistat inhibits gastrointestinal lipase and may lead to fat soluble vitamin (A, D, E, and K) deficiency, so consideration should be given to checking coagulation status preoperatively.
Negative_regulation (inhibits) of gastrointestinal lipase in fat
1) Confidence 0.51 Published 2005 Journal Anaesth Intensive Care Section Abstract Doc Link 16119498 Disease Relevance 0.25 Pain Relevance 0.24
Ritonavir/indinavir increased fexofenadine area under the plasma concentration-time curve four- to five-fold, suggesting significant inhibition of gastrointestinal P-glycoprotein.
Negative_regulation (inhibition) of gastrointestinal P-glycoprotein in plasma
2) Confidence 0.12 Published 2009 Journal Anesthesiology Section Body Doc Link 19225389 Disease Relevance 0 Pain Relevance 0
Methadone bioavailability was unchanged, despite inhibition of gastrointestinal P-glycoprotein activity, suggesting that this transporter does not limit methadone intestinal absorption.


Negative_regulation (inhibition) of gastrointestinal P-glycoprotein
3) Confidence 0.12 Published 2009 Journal Anesthesiology Section Body Doc Link 19225389 Disease Relevance 0 Pain Relevance 0
Orlistat is an agent that inhibits gastrointestinal lipase.
Negative_regulation (inhibits) of gastrointestinal lipase
4) Confidence 0.01 Published 2005 Journal J Int Soc Sports Nutr Section Body Doc Link PMC2129146 Disease Relevance 0.43 Pain Relevance 0.19

General Comments

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