INT129608

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 1.11
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adamts4) extracellular space (Adamts4) extracellular region (Adamts4)
proteinaceous extracellular matrix (Adamts4)
Anatomy Link Frequency
synovial fluids 1
anterior 1
TMJ 1
Adamts4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 10 100.00 Very High Very High Very High
substance P 3 99.60 Very High Very High Very High
Myofascial pain syndrome 5 97.88 Very High Very High Very High
fibrosis 1 96.72 Very High Very High Very High
Snapping jaw 9 89.48 High High
Neuropeptide 1 76.80 Quite High
Inflammation 1 74.80 Quite High
Pain 2 73.44 Quite High
Disease Link Frequency Relevance Heat
Temporomandibular Joint Disorders 9 97.88 Very High Very High Very High
Fibrosis 1 96.72 Very High Very High Very High
Temporomandibular Joint Syndrome 5 87.52 High High
Necrosis 1 82.12 Quite High
Cancer 1 81.76 Quite High
Intervertebral Disk Degeneration 3 80.32 Quite High
INFLAMMATION 1 74.80 Quite High
Pain 2 73.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULT: The incidence of aggrecanase expression in TMJD group were significantly higher than that in the normal control group (P < 0.05).
Gene_expression (expression) of aggrecanase
1) Confidence 0.77 Published 2005 Journal Oral Dis Section Body Doc Link 16120116 Disease Relevance 0.09 Pain Relevance 0
Those with severe OA and anterior disc displacement without reduction showed significantly high expression of aggrecanase compared with other disease subgroups (P < 0.05).
Gene_expression (expression) of aggrecanase in anterior
2) Confidence 0.67 Published 2005 Journal Oral Dis Section Body Doc Link 16120116 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: These findings suggested that expression of aggrecanase could be a potential biochemical marker for articular cartilage degradation in ID of the TMJ.


Gene_expression (expression) of aggrecanase in TMJ
3) Confidence 0.50 Published 2006 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 16831668 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The incidences of MMP-2, -9, and aggrecanase expression in the ID and OA group were significantly higher than those in the normal group (P < .05).
Gene_expression (expression) of aggrecanase
4) Confidence 0.50 Published 2006 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 16831668 Disease Relevance 0.09 Pain Relevance 0
Expression of matrix metalloproteinases and aggrecanase in the synovial fluids of patients with symptomatic temporomandibular disorders.
Gene_expression (Expression) of aggrecanase in synovial fluids associated with metalloproteinase and myofascial pain syndrome
5) Confidence 0.44 Published 2006 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 16831668 Disease Relevance 0.10 Pain Relevance 0.29
However, there was no significant difference in expression of MMP-2 and aggrecanase among disease subgroups.
Gene_expression (expression) of aggrecanase
6) Confidence 0.39 Published 2006 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 16831668 Disease Relevance 0.07 Pain Relevance 0
Conversely, comparatively high expression of MMP-2 and aggrecanase was shown in the early-stage OA group.
Gene_expression (expression) of aggrecanase
7) Confidence 0.39 Published 2006 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 16831668 Disease Relevance 0.07 Pain Relevance 0
The anti-catabolic effect of OP-1 was documented by reduced immunostaining for aggrecanase, MMP-13, substance P, TNF-alpha, and IL-1beta.
Gene_expression (immunostaining) of aggrecanase associated with substance p
8) Confidence 0.23 Published 2007 Journal J. Orthop. Res. Section Abstract Doc Link 17205567 Disease Relevance 0.55 Pain Relevance 0.39

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