INT129610

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Context Info
Confidence 0.74
First Reported 2006
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 7
Total Number 31
Disease Relevance 17.07
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Id2) nucleus (Id2) protein complex (Id2)
cytoplasm (Id2)
Anatomy Link Frequency
retinas 8
lens 3
brain 2
lens epithelium 2
diaphragm 1
Id2 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 432 98.92 Very High Very High Very High
Spinal cord 96 98.88 Very High Very High Very High
glial activation 48 98.76 Very High Very High Very High
anesthesia 29 82.44 Quite High
Inflammation 56 10.56 Low Low
ischemia 24 5.00 Very Low Very Low Very Low
alcohol 24 5.00 Very Low Very Low Very Low
peripheral neuropathy 24 5.00 Very Low Very Low Very Low
Glutamate 24 5.00 Very Low Very Low Very Low
Hippocampus 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 984 100.00 Very High Very High Very High
Injury 1177 99.82 Very High Very High Very High
Apoptosis 242 99.80 Very High Very High Very High
Pulmonary Disease 196 99.52 Very High Very High Very High
Retinal Perforations 48 99.48 Very High Very High Very High
Wound Healing 600 98.68 Very High Very High Very High
Diabetes Mellitus 24 97.52 Very High Very High Very High
Shock 72 97.04 Very High Very High Very High
Disease 68 95.60 Very High Very High Very High
Ganglion Cysts 120 89.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of lens epithelial cells and subsequent sealing of the capsular break with fibrous tissue in mice.
Gene_expression (transfer) of Id2 in lens associated with injury
1) Confidence 0.74 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.33 Pain Relevance 0.07
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of the lens epithelial cells as evaluated by histology and expression patterns of alpha-smooth muscle actin and collagens in association with reduction of Smad2 COOH-terminal phosphorylation.
Gene_expression (transfer) of Id2 in lens associated with injury
2) Confidence 0.74 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Exogenous BMP-7 upregulated expression of Id2 and Id3 in injured lenses, and gene introduction of Id2 or Id3 also upregulated BMP-7 expression.
Gene_expression (expression) of Id2 in lenses
3) Confidence 0.74 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Lpin1, Id2, and Sox11 were expressed in reactive glia of optic nerve heads (Yang et al. 2004) and diabetic retinas (Gerhardinger et al. 2005).
Gene_expression (expressed) of Id2 in retinas associated with diabetes mellitus
4) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.48 Pain Relevance 0.04
In forebrain, the expression variability of genes Lpin1, Id2, Sox11, and AL024210 mapped within the locus.
Gene_expression (expression) of Id2 in forebrain
5) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.39 Pain Relevance 0.05
In normal and injured retinas, Id2 and Lpin1 were more highly expressed in strains carrying the C57BL6 allele than in strains carrying the DBA/2J allele.
Gene_expression (expressed) of Id2 in retinas associated with sprains and strains
6) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.70 Pain Relevance 0.07
Our meta-analyses of publicly available data revealed that Lpin1, Id2, and Sox11 were differentially expressed during retinal development and trauma.
Gene_expression (expressed) of Id2 associated with injury
7) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.49 Pain Relevance 0.03
The mining of literature and publicly available microarrays revealed that Id2 is expressed by reactive glia in brain, spinal cord, and optic nerve head (Tzeng et al. 2001; Tzeng et al. 1999; Aronica et al. 2001; Hernandez et al. 2002).
Gene_expression (expressed) of Id2 in spinal cord associated with spinal cord
8) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.54 Pain Relevance 0.14
Using publicly available data on mouse retinal development (Dorrell et al. 2004), we determined that Lpin1, Id2, and Sox11 were expressed by the developing retina and had well defined patterns of expression (Fig. 3E; note that AL024210 levels were below detectable thresholds).
Gene_expression (expressed) of Id2 in retina
9) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.32 Pain Relevance 0.05
Genetic variability can explain the expression variability and strong linkage of Lpin1, Sox11, AL024210, and Id2 to their gene locations (cis-eQTLs).
Gene_expression (expression) of Id2
10) Confidence 0.74 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.19 Pain Relevance 0.08
We have examined the effect of adenovirus-mediated expression of bone morphogenic protein-7 (BMP-7) and inhibitors of differentiation 2 and 3 (Id2 and Id3) on injury-induced epithelial-to-mesenchymal transition (EMT) of lens epithelium in mice.
Spec (examined) Gene_expression (expression) of Id2 in lens epithelium associated with injury
11) Confidence 0.65 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.24 Pain Relevance 0.06
Together these results documented that Lpin1, Id2, and Sox11 are candidate genes, because they displayed (1) cis-eQTLs in the brain, cerebellum, and striatum; (2) polymorphisms between parental strains; (3) differential expression during retinal development and retinal healing; and (4) moderate to high levels of expression in normal and reactive neural cells.
Gene_expression (expression) of Id2 in brain associated with sprains and strains
12) Confidence 0.64 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.73 Pain Relevance 0.03
Higher levels of Id2 and Lpin1 correlated with higher levels of neuronal marker Thy1 and heat-shock-like crystallin genes (Cryab, Cryba4, and Crygd).
Gene_expression (levels) of Id2 in neuronal associated with shock
13) Confidence 0.64 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.71 Pain Relevance 0.07
Moreover, Id2 silencing in cultured cerebellar astrocytes resulted in a mitigated reactive response, mainly a decrease in migration and proliferation (see Supplementary Fig. 3) (Vazquez-Chona, 2006).
Gene_expression (silencing) of Id2 in astrocytes
14) Confidence 0.64 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.42 Pain Relevance 0.14
Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice.
Gene_expression (transfer) of Id2 in lens epithelium associated with injury
15) Confidence 0.58 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Title Doc Link 16120655 Disease Relevance 0.26 Pain Relevance 0.07
To investigate the role of chromosome 12 locus, we compared the wound-healing response of retinas that expresses high levels of Id2/Lpin1 (strains with the C57BL/6 allele) to retinas expressing low levels of Id2/Lpin1 (strains with the DBA/2J allele) (Fig. 5).
Gene_expression (expresses) of Id2 in retinas associated with injury and sprains and strains
16) Confidence 0.57 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.85 Pain Relevance 0
In models of retinal tear and toxic injury, higher Id2 and Lpin1 expression levels and fold changes were also observed in BXD38 retinas relative to DBA/2J retinas (Supplementary Fig. 2C and 2D).
Gene_expression (expression) of Id2 in retinas associated with retinal perforations and injury
17) Confidence 0.57 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.80 Pain Relevance 0
Based on expression data from injured BXD retinas, the expression patterns for Id2 and Lpin1 correlated positively with the C57BL/6 allele.
Gene_expression (expression) of Id2 in retinas
18) Confidence 0.57 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.70 Pain Relevance 0
Moreover, the C57BL/6 allele (high Id2/Lpin1 expresser) displayed greater changes in glial cells for the protective STAT3 signaling and for the negative regulator of glial proliferation CD81.


Gene_expression (expresser) of Id2 in glial cells
19) Confidence 0.57 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.55 Pain Relevance 0.07
Stat3 expression patterns strongly correlated with those of Id2 and Lpin1 (r = 0.87 and r = 0.88).
Gene_expression (expression) of Id2
20) Confidence 0.57 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.29 Pain Relevance 0.09

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