INT129612

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 3.61
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Id2) nucleus (Id2) protein complex (Id2)
cytoplasm (Id2)
Anatomy Link Frequency
lens 4
soleus 3
lens epithelium 2
diaphragm 1
Id2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 3 77.60 Quite High
Inflammation 56 10.92 Low Low
cytokine 12 5.00 Very Low Very Low Very Low
corticosteroid 8 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 26 99.80 Very High Very High Very High
Pulmonary Disease 196 99.70 Very High Very High Very High
Injury 15 99.32 Very High Very High Very High
Muscular Atrophy 10 84.96 Quite High
Obesity 4 69.48 Quite High
Frailty 76 66.88 Quite High
Targeted Disruption 4 65.76 Quite High
Atrophic Muscular Disorders 2 51.04 Quite High
Cancer 10 30.96 Quite Low
Chronic Disease 12 30.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of lens epithelial cells and subsequent sealing of the capsular break with fibrous tissue in mice.
Positive_regulation (transfer) of Gene_expression (transfer) of Id2 in lens associated with injury
1) Confidence 0.67 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.33 Pain Relevance 0.07
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of the lens epithelial cells as evaluated by histology and expression patterns of alpha-smooth muscle actin and collagens in association with reduction of Smad2 COOH-terminal phosphorylation.
Positive_regulation (transfer) of Gene_expression (transfer) of Id2 in lens associated with injury
2) Confidence 0.48 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice.
Positive_regulation (transfer) of Gene_expression (transfer) of Id2 in lens epithelium associated with injury
3) Confidence 0.45 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Title Doc Link 16120655 Disease Relevance 0.26 Pain Relevance 0.07
This has not yet been investigated in patients with COPD, but both the elevated expression of Id2 protein and apoptotic factors in the diaphragm and soleus of the emphysematous hamster (Alway et al 2004) hint to this possibility.
Positive_regulation (elevated) of Gene_expression (expression) of Id2 protein in soleus associated with pulmonary disease and apoptosis
4) Confidence 0.01 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 1.35 Pain Relevance 0
This has not yet been investigated in patients with COPD, but both the elevated expression of Id2 protein and apoptotic factors in the diaphragm and soleus of the emphysematous hamster (Alway et al 2004) hint to this possibility.
Positive_regulation (elevated) of in diaphragm Gene_expression (expression) of Id2 protein in soleus associated with pulmonary disease and apoptosis
5) Confidence 0.00 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695204 Disease Relevance 1.35 Pain Relevance 0

General Comments

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