INT129615

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Context Info
Confidence 0.66
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.22
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Id2) nucleus (Id2) protein complex (Id2)
cytoplasm (Id2)
Anatomy Link Frequency
retina 1
spinal cord 1
brain 1
ganglion cell 1
lenses 1
Id2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 16 97.68 Very High Very High Very High
Central nervous system 72 86.68 High High
anesthesia 5 80.28 Quite High
glial activation 8 75.12 Quite High
ischemia 4 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
peripheral neuropathy 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 96.24 Very High Very High Very High
Injury 197 93.04 High High
Apoptosis 36 92.92 High High
Shock 12 72.76 Quite High
Sprains And Strains 164 67.64 Quite High
Wound Healing 100 62.56 Quite High
Gliosis 8 29.72 Quite Low
Death 24 5.00 Very Low Very Low Very Low
Stress 16 5.00 Very Low Very Low Very Low
Fatty Liver 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Id2 is also upregulated as an immediate early gene in injured retina, brain, and spinal cord (Vazquez-Chona et al. 2005).
Positive_regulation (upregulated) of Id2 in spinal cord associated with spinal cord
1) Confidence 0.66 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.45 Pain Relevance 0.14
Exogenous BMP-7 upregulated expression of Id2 and Id3 in injured lenses, and gene introduction of Id2 or Id3 also upregulated BMP-7 expression.
Positive_regulation (introduction) of Id2 in lenses
2) Confidence 0.48 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.31 Pain Relevance 0.08
Based on these results, the C57BL/6 allele (greater Id2/Lpin1 fold changes) correlated with higher expression levels of survival genes including the ganglion cell gene Thy1 and crystallin genes (Cryab, Cryba4, and Crygd).
Positive_regulation (greater) of Id2 in ganglion cell associated with ganglion cysts
3) Confidence 0.42 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.57 Pain Relevance 0.07
Id2 is also upregulated as an immediate early gene in injured retina, brain, and spinal cord (Vazquez-Chona et al. 2005).
Positive_regulation (upregulated) of Id2 in retina associated with spinal cord
4) Confidence 0.22 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.45 Pain Relevance 0.14
Id2 is also upregulated as an immediate early gene in injured retina, brain, and spinal cord (Vazquez-Chona et al. 2005).
Positive_regulation (upregulated) of Id2 in brain associated with spinal cord
5) Confidence 0.22 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.45 Pain Relevance 0.14

General Comments

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