INT129616

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Context Info
Confidence 0.38
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.78
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
retina 4
lens 2
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 7 69.60 Quite High
cytokine 10 58.48 Quite High
ischemia 2 51.28 Quite High
Inflammation 50 50.00 Quite Low
imagery 2 15.40 Low Low
fibrosis 14 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Neurotransmitter 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 9 96.90 Very High Very High Very High
Ganglion Cysts 26 85.00 Quite High
Edema 4 59.92 Quite High
Pre-eclampsia 6 57.88 Quite High
Proteinuria 2 52.48 Quite High
Hypertension 2 51.84 Quite High
Cv Unclassified Under Development 2 51.28 Quite High
INFLAMMATION 50 50.00 Quite Low
Adenovirus Infection 2 48.16 Quite Low
Keloid Scars 8 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of samples treated with 200 nM TSA did not completely block phosphorylation of Smad2; instead, it faintly reduced the pSmad2 levels at 2 h post-TGF?
Negative_regulation (block) of Phosphorylation (phosphorylation) of Smad2
1) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of the lens epithelial cells as evaluated by histology and expression patterns of alpha-smooth muscle actin and collagens in association with reduction of Smad2 COOH-terminal phosphorylation.
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Smad2 in lens associated with injury
2) Confidence 0.32 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.29 Pain Relevance 0.07
TSA at a concentration of 500 nM substantially reduced the Smad2 phosphorylation level at 2 h.
Negative_regulation (level) of Phosphorylation (phosphorylation) of Smad2
3) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.03
decreases smad2 phosphorylation in the retina
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of smad2 in retina
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.33 Pain Relevance 0.03
Western blot analysis for pp-smad2 on whole retina lysates indicated a marked reduction of smad2 phosphorylation in Ad-sEng mice compared to the control after seven days (Figure 1E; Figure 1F quantification), demonstrating that systemic expression of sEng effectively neutralizes TGF-?
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of smad2 in retina
5) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2659748 Disease Relevance 0.16 Pain Relevance 0

General Comments

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