INT129619

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Context Info
Confidence 0.61
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 34
Total Number 45
Disease Relevance 11.60
Pain Relevance 1.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Smad2) intracellular (Smad2) protein complex (Smad2)
transcription factor binding (Smad2) cytoplasm (Smad2)
Anatomy Link Frequency
MDA-MB-231 3
retina 2
nucleus 2
4T1 2
skin 2
Smad2 (Mus musculus)
Pain Link Frequency Relevance Heat
Osteoarthritis 382 97.00 Very High Very High Very High
cytokine 94 92.16 High High
Inflammation 358 81.60 Quite High
Arthritis 6 79.28 Quite High
anesthesia 47 69.08 Quite High
Bioavailability 5 69.04 Quite High
fibrosis 225 67.48 Quite High
ischemia 6 50.88 Quite High
agonist 56 50.00 Quite Low
antagonist 34 50.00 Quite Low
Disease Link Frequency Relevance Heat
Aging 110 99.04 Very High Very High Very High
Osteoarthritis 402 97.00 Very High Very High Very High
Injury 64 96.64 Very High Very High Very High
Ganglion Cysts 52 96.40 Very High Very High Very High
Cancer 727 95.16 Very High Very High Very High
Breast Cancer 305 94.72 High High
Apoptosis 320 92.84 High High
Targeted Disruption 31 92.00 High High
Fibrosis 294 91.84 High High
Metastasis 407 90.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of the lens epithelial cells as evaluated by histology and expression patterns of alpha-smooth muscle actin and collagens in association with reduction of Smad2 COOH-terminal phosphorylation.
Phosphorylation (phosphorylation) of Smad2 in lens associated with injury
1) Confidence 0.61 Published 2006 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16120655 Disease Relevance 0.29 Pain Relevance 0.07
1 addition compared to the Smad2 phosphorylation level noted 1 h post-TGF?
Phosphorylation (phosphorylation) of Smad2
2) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.11 Pain Relevance 0.03
The phosphorylated Smad2 and Smad3 then form a complex with Smad4 and translocate to the nucleus [29,30].
Phosphorylation (phosphorylated) of Smad2 in nucleus
3) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.08 Pain Relevance 0.04
to its receptor phosphorylates Smad2/3 and activates the signaling cascade.
Phosphorylation (phosphorylates) of Smad2
4) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.08 Pain Relevance 0.04
The levels of phosphorylation of Smad2 in control samples were about the same at 1 and 2 h.
Phosphorylation (phosphorylation) of Smad2
5) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.12 Pain Relevance 0.03
Samples were washed, fixed with 4% paraformaldehyde, and processed for immunocytochemistry for phosphorylated Smad2 (pSmad2) using anti-phospho-Smad2 antibody (Chemicon) [25].


Phosphorylation (phosphorylated) of Smad2
6) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
Western blot analysis of samples treated with 200 nM TSA did not completely block phosphorylation of Smad2; instead, it faintly reduced the pSmad2 levels at 2 h post-TGF?
Phosphorylation (phosphorylation) of Smad2
7) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
The results of our study show that TSA upregulates Smad7 (an inhibitory Smad that blocks phosphorylation of Smad2/3) and TGIF (a co-repressor of Smad-dependent gene expression that directly associates with Smad proteins) and inhibits Smad-mediated transcriptional activation in cultured subconjunctival fibroblasts.
Phosphorylation (phosphorylation) of Smad2 in fibroblasts
8) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.06 Pain Relevance 0.03
While the cells maintained a similar level of phosphorylation of Smad2 until 2 h in the absence of TSA.
Phosphorylation (phosphorylation) of Smad2
9) Confidence 0.54 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
We speculate that this might be due to Smad2 import in the nuclei as TSA not only reduces the phosphorylation level of Smad2 but also inhibits its import to the nuclei.
Phosphorylation (phosphorylation) of Smad2
10) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0.17 Pain Relevance 0.04
TSA at a concentration of 500 nM substantially reduced the Smad2 phosphorylation level at 2 h.
Phosphorylation (phosphorylation) of Smad2
11) Confidence 0.53 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0.03
The phosphorylation status of SMAD1 and SMAD2 were assayed as representative of the activity of the osteogenic (BMP-stimulated) and non-osteogenic (TGF-?
Phosphorylation (phosphorylation) of SMAD2
12) Confidence 0.51 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2896919 Disease Relevance 0.20 Pain Relevance 0
Samples were washed, fixed with 4% paraformaldehyde, and processed for immunocytochemistry for phosphorylated Smad2 (pSmad2) using anti-phospho-Smad2 antibody (Chemicon) [25].


Phosphorylation (phosphorylated) of pSmad2
13) Confidence 0.47 Published 2010 Journal Molecular Vision Section Body Doc Link PMC3013068 Disease Relevance 0 Pain Relevance 0
It was reported that SPARC stimulated Smad2 phosphorylation and Smad2/3 nuclear translation in lung epithelial cells [27].
Phosphorylation (phosphorylation) of Smad2 in lung
14) Confidence 0.45 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888211 Disease Relevance 0.49 Pain Relevance 0.10
Phosphorylated Smad2 and Smad3, the effectors of the TGF-?
Phosphorylation (Phosphorylated) of Smad2
15) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682659 Disease Relevance 0.09 Pain Relevance 0
Expression of non phosphorylated Smad2 was not altered during ageing.
Phosphorylation (phosphorylated) of Smad2 associated with aging
16) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.74 Pain Relevance 0.20
type I receptor ALK5 and phosphorylation of Smad2/3 in murine articular cartilage [84].
Phosphorylation (phosphorylation) of Smad2 in articular cartilage
17) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875624 Disease Relevance 0.71 Pain Relevance 0.19
signaling were confirmed by Western blot for phosphorylated Smad2.
Phosphorylation (phosphorylated) of Smad2
18) Confidence 0.43 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731927 Disease Relevance 0 Pain Relevance 0
-mediated phosphorylation of Smad2 and Smad3 in both murine 4T1 and human MDA-MB-231 cells.
Phosphorylation (phosphorylation) of Smad2 in MDA-MB-231
19) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.61 Pain Relevance 0
1 treatment (2 ng/ml), doxorubicin treatment (25 nM) also stimulated phosphorylation of Smad2 and Smad3 proteins in both 4T1 and MDA-MB-231 (Figure 2) cells, which was inhibited by the addition of the TGF?
Phosphorylation (phosphorylation) of Smad2 in 4T1
20) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2860989 Disease Relevance 0.51 Pain Relevance 0

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