INT129630

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Context Info
Confidence 0.44
First Reported 2003
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.94
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
fat 1
motor neurons 1
Sod1 (Mus musculus)
Sod1 - G93A (1)
Pain Link Frequency Relevance Heat
cytokine 3 97.82 Very High Very High Very High
COX2 2 91.88 High High
Demyelination 1 89.92 High High
Spinal cord 30 83.84 Quite High
cerebral cortex 2 76.32 Quite High
Neurotransmitter 6 64.40 Quite High
agonist 5 63.72 Quite High
cINOD 2 57.88 Quite High
Inflammation 4 51.56 Quite High
Hippocampus 10 19.92 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 42 100.00 Very High Very High Very High
Burns 2 99.68 Very High Very High Very High
Disease 36 99.28 Very High Very High Very High
Motor Neuron Diseases 107 98.12 Very High Very High Very High
Death 48 96.88 Very High Very High Very High
Paralysis 5 96.48 Very High Very High Very High
Muscular Atrophy 3 96.04 Very High Very High Very High
Stress 14 95.84 Very High Very High Very High
Demyelinating Disease 1 89.92 High High
Neurodegenerative Disease 18 79.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, mRNA levels of the suppressor of cytokine signaling 1 and 3 genes were increased by Pio, whereas both the mRNA and protein levels of endogenous mouse SOD1 and of transgenic human SOD1 remained unaffected.
Neg (unaffected) Regulation (unaffected) of SOD1 associated with targeted disruption and cytokine
1) Confidence 0.44 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16120782 Disease Relevance 0.68 Pain Relevance 0.28
Measures of motor performance: Rotarod testing was used to determine the effect of the KD on the loss of motor function in SOD1-G93A transgenic mice.
Spec (determine) Regulation (effect) of SOD1 (G93A) associated with targeted disruption
2) Confidence 0.43 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1488864 Disease Relevance 0.67 Pain Relevance 0.03
Interestingly, mRNA levels of the suppressor of cytokine signaling 1 and 3 genes were increased by Pio, whereas both the mRNA and protein levels of endogenous mouse SOD1 and of transgenic human SOD1 remained unaffected.
Neg (unaffected) Regulation (unaffected) of SOD1 associated with targeted disruption and cytokine
3) Confidence 0.39 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16120782 Disease Relevance 0.67 Pain Relevance 0.27
The disease causing property of mutant SOD1 is independent of the normal SOD1 activity, and thus, mutant SOD1 kills motor neurons by gaining a toxic property (reviewed in [9,10]).
Neg (independent) Regulation (independent) of SOD1 in motor neurons associated with disease
4) Confidence 0.26 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC169170 Disease Relevance 1.35 Pain Relevance 0.04
mice attempt to store rather than burn fat.

(4) An up-regulation of genes encoding key enzymatic and nonenzymatic low–molecular mass scavengers and antioxidant defense enzymes (e.g., Sod1, Prdx2 and 3, Txnip, Ephx1, Hmox1 and five components of the glutathione system) (Table 1), suggesting that Csbm/m/Xpa?

Regulation (regulation) of Sod1 in fat associated with burns
5) Confidence 0.23 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1698505 Disease Relevance 0.16 Pain Relevance 0
In summary, CPZ acts on cupric enzymes, including SOD1, cytochrome oxidase, and D?
Regulation (acts) of SOD1
6) Confidence 0.18 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2842101 Disease Relevance 0.51 Pain Relevance 0.12
All 4 cases in this report were negative for changes in SOD1, ANG, TDP43, VAPB and FUS/TLS.
Regulation (changes) of SOD1
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.88 Pain Relevance 0

General Comments

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