INT129645

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 3.33
Pain Relevance 5.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (TAC1) extracellular region (TAC1) plasma membrane (TAC1)
cell-cell signaling (TAC1)
Anatomy Link Frequency
spinal 4
cerebrospinal fluid 2
spinal cord 2
hippocampus 2
TAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 62 100.00 Very High Very High Very High
Delta opioid receptors 14 100.00 Very High Very High Very High
Hippocampus 6 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Hyperalgesia 2 99.88 Very High Very High Very High
Enkephalin 2 99.80 Very High Very High Very High
Spinal cord 7 99.68 Very High Very High Very High
ketamine 3 99.60 Very High Very High Very High
analgesia 11 99.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 73 100.00 Very High Very High Very High
Hyperalgesia 2 99.88 Very High Very High Very High
Pressure And Volume Under Development 1 99.60 Very High Very High Very High
Nociception 42 99.10 Very High Very High Very High
Stress 6 95.48 Very High Very High Very High
Sleep Disorders 5 92.16 High High
Lumbar Puncture Related Headaches 3 91.92 High High
Leukemia 5 90.84 High High
INFLAMMATION 4 83.36 Quite High
Anxiety Disorder 3 83.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results showed that indomethacin significantly reduced nociception-related peripheral edema, hyperalgesia, and reversed the pain-evoked up-regulation of neurokinin (NK)-1 receptor and brain-derived neurotrophic factor (BDNF) gene expression in the spinal cord to levels not statistically different from controls.
Negative_regulation (reversed) of Gene_expression (expression) of neurokinin in spinal cord associated with nociception, pain, pressure and volume under development, hyperalgesia and spinal cord
1) Confidence 0.42 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16956981 Disease Relevance 1.48 Pain Relevance 1.49
Furthermore, deletion of the preprotachykinin A gene reduced stimulus-induced surface insertion of DORs and abolished DOR-mediated spinal analgesia and morphine tolerance.
Negative_regulation (reduced) of Gene_expression (deletion) of tachykinin in spinal associated with tolerance, delta opioid receptors, morphine and analgesia
2) Confidence 0.41 Published 2005 Journal Cell Section Abstract Doc Link 16122428 Disease Relevance 0.15 Pain Relevance 1.37
Furthermore, deletion of the preprotachykinin A gene reduced stimulus-induced surface insertion of DORs and abolished DOR-mediated spinal analgesia and morphine tolerance.
Negative_regulation (abolished) of Gene_expression (deletion) of tachykinin in spinal associated with tolerance, delta opioid receptors, morphine and analgesia
3) Confidence 0.41 Published 2005 Journal Cell Section Abstract Doc Link 16122428 Disease Relevance 0.15 Pain Relevance 1.39
We also evaluated the levels of nerve growth factor, substance P and enkephalins in the cerebrospinal fluid of these patients.
Negative_regulation (evaluated) of Gene_expression (levels) of substance P in cerebrospinal fluid associated with nerve growth factor, enkephalin and substance p
4) Confidence 0.41 Published 2010 Journal Eur J Cancer Care (Engl) Section Abstract Doc Link 19490010 Disease Relevance 1.22 Pain Relevance 0.77
Moreover, the expression of neurokinin 1 receptors and brain-derived neurotrophin factors in the hippocampus was also suppressed by subcutaneous injection of formalin [35,36].
Negative_regulation (suppressed) of Gene_expression (expression) of neurokinin 1 in hippocampus associated with hippocampus
5) Confidence 0.41 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759921 Disease Relevance 0.33 Pain Relevance 0.52

General Comments

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