INT129672

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2007
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.72
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Anatomy Link Frequency
dermis 1
mast cells 1
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 16 94.52 High High
Serotonin 24 86.32 High High
antinociception 2 50.00 Quite Low
cytokine 4 38.60 Quite Low
Analgesic 1 10.00 Low Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 196 99.96 Very High Very High Very High
Anaphylaxis 40 99.72 Very High Very High Very High
Hypersensitivity 24 70.40 Quite High
Sprains And Strains 12 12.96 Low Low
Syndrome 8 5.00 Very Low Very Low Very Low
Disease 8 5.00 Very Low Very Low Very Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low
Asthma 8 5.00 Very Low Very Low Very Low
Exsanguination 4 5.00 Very Low Very Low Very Low
Edema 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data suggest that MT-dependent secretory granule movements are increased in double Rab27 KO mast cells, presumably because of a disconnection between MT and actin motor systems (Figure 6; Table 1).
Positive_regulation (increased) of Rab27 in mast cells associated with targeted disruption
1) Confidence 0.69 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.40 Pain Relevance 0.05
Surprisingly, the PCA response was enhanced in Rab27a KO mice dermis (Figure 2A).
Positive_regulation (enhanced) of Rab27a in dermis associated with targeted disruption and anaphylaxis
2) Confidence 0.50 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.86 Pain Relevance 0.06
Conversely, in Rab27b KO or double KO BMMCs, the histamine-positive granules appeared more clustered (Figure 4) in a subset of BMMCs, more specifically 32% of Rab27b KO (n = 34) and 63% of double KO (n = 8) BMMCs, compared with no obvious accumulation of granules in wild-type (n = 55), Rab27a+/ash (n = 11), Rab27aash/ash (n = 36), Rab27b+/?
Neg (no) Positive_regulation (accumulation) of Rab27a associated with targeted disruption
3) Confidence 0.47 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.73 Pain Relevance 0.04
Conversely, in Rab27b KO or double KO BMMCs, the histamine-positive granules appeared more clustered (Figure 4) in a subset of BMMCs, more specifically 32% of Rab27b KO (n = 34) and 63% of double KO (n = 8) BMMCs, compared with no obvious accumulation of granules in wild-type (n = 55), Rab27a+/ash (n = 11), Rab27aash/ash (n = 36), Rab27b+/?
Neg (no) Positive_regulation (accumulation) of Rab27aash associated with targeted disruption
4) Confidence 0.47 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.73 Pain Relevance 0.04
Pre-treatment with L-arginine was found to significantly reverse the three respective doses of ASH antinociception; pre-treatment with D-arginine did not produce any significant change in the ASH activity; pre-treatment with L-NAME only significantly increased the 0.170 and 0.426 mg/kg ASH antinociception; and pre-treatment with MB significantly enhanced the respective doses of ASH antinociception, respectively.
Positive_regulation (increased) of ASH
5) Confidence 0.41 Published 2005 Journal J Pharm Pharm Sci Section Body Doc Link 16124931 Disease Relevance 0 Pain Relevance 0

General Comments

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