INT129678

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Context Info
Confidence 0.78
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.57
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hsf1) DNA binding (Hsf1) protein complex (Hsf1)
response to stress (Hsf1) cytoplasm (Hsf1)
Anatomy Link Frequency
liver 2
filaments 1
brain 1
hearts 1
Hsf1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 6 100.00 Very High Very High Very High
endometriosis 8 97.84 Very High Very High Very High
anesthesia 4 96.96 Very High Very High Very High
addiction 8 77.44 Quite High
ischemia 14 75.00 Quite High
agonist 24 67.08 Quite High
Hsan 1 65.32 Quite High
Pain 1 44.16 Quite Low
Central nervous system 11 40.08 Quite Low
Hippocampus 13 26.00 Quite Low
Disease Link Frequency Relevance Heat
Shock 650 100.00 Very High Very High Very High
Cystic Fibrosis 1 100.00 Very High Very High Very High
Targeted Disruption 99 99.08 Very High Very High Very High
Fever 16 98.88 Very High Very High Very High
Endometriosis (extended) 8 97.84 Very High Very High Very High
Fibrosis 5 85.16 High High
Sprains And Strains 44 84.48 Quite High
Alzheimer's Dementia 36 84.24 Quite High
Apoptosis 39 81.40 Quite High
Myeloid Leukemia 36 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the silencing effect of siRNA on HSF1 and HSPs gene expression was transient and its inhibitory effect disappeared by 10 days after treatment. siRNA-HSF1 also impaired the thermotolerance of the heat shocked mice as indicated by higher mortality following WBH.
Gene_expression (expression) of HSF1 associated with fever
1) Confidence 0.78 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 0.70 Pain Relevance 0.15
However, we did not observe changes in Hsf1 expression in our transcript profiling studies and earlier studies showed that HSF1 and HSF2 expression and binding to HSE was not altered by WY exposure in the rat liver [64].
Gene_expression (expression) of Hsf1 in liver
2) Confidence 0.75 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.85 Pain Relevance 0
WBH preconditioning resulted in 2.7-fold and 3.4-fold increase in cardiac HSF1 mRNA and protein expression respectively 2 hours after WBH, which was inhibited in the siRNA-treated mice.
Gene_expression (expression) of HSF1 associated with fever
3) Confidence 0.68 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16125197 Disease Relevance 1.03 Pain Relevance 0.17
While HSF1 was present in the cytosol of the NTG hearts, obvious nuclear localization was seen in the R120G TG hearts with or without GGA treatment (Figure 3F).
Gene_expression (present) of HSF1 in hearts associated with targeted disruption
4) Confidence 0.66 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2670514 Disease Relevance 1.67 Pain Relevance 0.08
Given that Hsp gene expression is controlled in part by heat shock factor 1 (HSF1), one possibility is that the increases in Hsp gene expression are secondary to increases in the expression and activity of HSF1.
Gene_expression (expression) of HSF1 associated with shock
5) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.88 Pain Relevance 0
However, we did not observe changes in Hsf1 expression in our transcript profiling studies and earlier studies showed that HSF1 and HSF2 expression and binding to HSE was not altered by WY exposure in the rat liver [64].
Gene_expression (expression) of HSF1 in liver
6) Confidence 0.65 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.84 Pain Relevance 0
We identified a number of classes of HSF1-dependent or -independent genes regulated by HS as well as genes that require HSF1 for basal expression (Additional File 10 and 11).
Gene_expression (expression) of HSF1 associated with shock
7) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2823686 Disease Relevance 0.60 Pain Relevance 0.07
Interestingly, a negative regulator of HSFs, HSF-binding protein 1 (Hsbp1) [74], is highly expressed in all brain regions.
Gene_expression (expressed) of HSF-binding protein 1 in brain
8) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.38 Pain Relevance 0.07
This brings down the transcriptional activity of HSF1 and Hsp70 production in K562 cells.
Gene_expression (production) of HSF1
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806839 Disease Relevance 0.15 Pain Relevance 0
rendered HSF1 transcriptionally inactive and reduced Hsp70 production.
Gene_expression (production) of HSF1
10) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806839 Disease Relevance 0.55 Pain Relevance 0
In contrast Wortmanin at both the above concentrations clearly decreased the levels of nuclear HSF1 (Fig 2B).
Gene_expression (levels) of HSF1
11) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806839 Disease Relevance 0.13 Pain Relevance 0
In the coding region, putative regulatory factors include AHR/ARNT, USF, ELK1, HSF1, HSF2, ARP1, RFX1, GATA1, AP4, E2F, and ARP1.
Gene_expression (include) of HSF1
12) Confidence 0.16 Published 2009 Journal Neural Plasticity Section Body Doc Link PMC2801004 Disease Relevance 0.13 Pain Relevance 0
Biological pathway analysis identified that cytoskeletal remodeling via keratin intermediate filaments, processing of the cystic fibrosis transmembrane receptor (CFTR), the glucocorticoid receptor subunit alpha (GCR), and heat shock factor 1 (HSF1) were all significantly over-represented features in endometriosis patients.
Gene_expression (processing) of HSF1 in filaments associated with endometriosis, fibrosis, shock and cystic fibrosis
13) Confidence 0.08 Published 2010 Journal J. Proteome Res. Section Abstract Doc Link 20199104 Disease Relevance 0.65 Pain Relevance 0.32

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