INT129685

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.44
Pain Relevance 5.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
neuronal 1
astrocytes 1
dorsal horn 1
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 152 100.00 Very High Very High Very High
Brush evoked pain 3 100.00 Very High Very High Very High
Neuropathic pain 134 99.96 Very High Very High Very High
spinal dorsal horn 21 99.26 Very High Very High Very High
ketamine 94 98.68 Very High Very High Very High
Hyperalgesia 18 97.72 Very High Very High Very High
allodynia 71 97.52 Very High Very High Very High
glial activation 3 96.40 Very High Very High Very High
Inflammation 8 93.44 High High
antagonist 16 92.56 High High
Disease Link Frequency Relevance Heat
Neuropathic Pain 228 100.00 Very High Very High Very High
Hyperalgesia 24 97.72 Very High Very High Very High
Spinal Injuries 1 94.00 High High
INFLAMMATION 5 93.44 High High
Otitis 1 83.24 Quite High
Pain 52 75.00 Quite High
Nervous System Injury 66 71.52 Quite High
Ganglion Cysts 35 69.24 Quite High
Injury 43 64.72 Quite High
Hypersensitivity 25 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, SNL itself produced a significant allodynia which was incubated with time; SO treatment did not change the neuropathic pain performance after SNL, while ASO treatment reversed the SNL-induced neuropathic pain with a long-lasting effect.
Negative_regulation (reversed) of SNL-induced associated with allodynia, spinal nerve ligature and neuropathic pain
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.72 Pain Relevance 1.27
We also found that enhanced GFAP expression possibly reflecting astroglial activation and enhanced Iba 1 expression possibly reflecting microglial migration identified in L5 spinal dorsal horn from neuropathic mice were strongly suppressed in SNL-operated Cav2.2-/- mice.
Negative_regulation (suppressed) of SNL in dorsal horn associated with spinal dorsal horn and neuropathic pain
2) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.91 Pain Relevance 0.73
Our finding that SNL results in a decrease in immunoreactivity for phospho p70S6K in the corresponding lumbar spinal segment (L5) is of particular interest because intuitively, based on previous studies, particularly concerning neuronal activity in the brain, a condition like neuropathy would be expected to result in an increase in phospho p70S6K immunoreactivity.5,21,35,36 Intriguingly, one-third of lamina II interneurons receive simultaneous monosynaptic inputs from 2 to 4 different segmental roots.23 This model of organization, where substantia gelatinosia spinal neurons at L4 receive major monosynaptic input from L4-L6 roots, suggests that the reduction in L5 phospho p70S6K and CGRP immunoreactivity after SNL should also be observed in L4 (even though at this level, spinal nerves are not ligated) and that neurons within L4 will have reduced responses.
Negative_regulation (reduction) of SNL in neuronal associated with neuropathic pain
3) Confidence 0.03 Published 2010 Journal The Journal of Pain Section Body Doc Link PMC3000494 Disease Relevance 0.16 Pain Relevance 0.21
In the L5 SNL and INC surgical procedures, tactile allodynia produced by both procedures was significantly reduced by 30mg/kg i.p. of AR-C102222.
Negative_regulation (reduced) of SNL associated with brush evoked pain
4) Confidence 0.02 Published 2006 Journal Eur J Pain Section Abstract Doc Link 16125426 Disease Relevance 0.92 Pain Relevance 1.14
To test this hypothesis, we employed SNL-induced neuropathic pain model. ketamine or astrocytes specific cytotoxin L-?
Negative_regulation (employed) of SNL in astrocytes associated with ketamine, spinal nerve ligature and neuropathic pain
5) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.62 Pain Relevance 1.46
However, DNP-induced channel opening was significantly reduced in SNL (NPo = 0.208 ± 0.16) compared to SS (NPo = 0.442 ± 0.26; p = 0.04 vs.
Negative_regulation (reduced) of SNL
6) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2673211 Disease Relevance 0.11 Pain Relevance 0.11
Intensity of anti-SUR1 fluorescence in SLI was 12% less in SNL compared to control (p < 0.01; Fig. 6I4).
Negative_regulation (less) of SNL associated with spinal nerve ligature
7) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2825500 Disease Relevance 0 Pain Relevance 0.76

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