INT129686

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 46
Total Number 46
Disease Relevance 18.91
Pain Relevance 34.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (FSCN1) cell motility (FSCN1) protein binding, bridging (FSCN1)
cytoplasm (FSCN1)
Anatomy Link Frequency
neurons 8
plasma 2
spinal cord 2
dorsal horn 2
neuronal 2
FSCN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 1339 100.00 Very High Very High Very High
Spinal cord 327 100.00 Very High Very High Very High
dorsal root ganglion 226 100.00 Very High Very High Very High
Eae 76 100.00 Very High Very High Very High
Sciatic nerve 6 100.00 Very High Very High Very High
Brush evoked pain 38 99.98 Very High Very High Very High
ketamine 1316 99.96 Very High Very High Very High
allodynia 782 99.92 Very High Very High Very High
Thalamus 178 99.60 Very High Very High Very High
nMDA receptor 133 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 239 100.00 Very High Very High Very High
Ganglion Cysts 231 100.00 Very High Very High Very High
Neuropathic Pain 2176 99.98 Very High Very High Very High
Nervous System Injury 386 99.00 Very High Very High Very High
Hyperalgesia 111 98.92 Very High Very High Very High
Otitis 1 97.82 Very High Very High Very High
Sprains And Strains 128 97.64 Very High Very High Very High
Lymphatic System Cancer 7 97.36 Very High Very High Very High
Skin Cancer 39 96.64 Very High Very High Very High
Merkel Cell Carcinoma 11 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly we did not detect cold hyperalgesia in the SNL model at -5°C, even though an increase in the percentage of cold responsive neurons in the uninjured L4 DRG following SNL has been reported [20].
Gene_expression (following) of SNL in neurons associated with hyperalgesia, cold hyperalgesia and eae
1) Confidence 0.15 Published 2005 Journal Mol Pain Section Body Doc Link PMC1325266 Disease Relevance 1.19 Pain Relevance 1.19
Besides its effect on the SNL-induced ipsilateral mechanic allodynia, c-fos ASO significantly inhibited SNL-induced Fos protein expression in the ipsilateral dorsal horn.
Gene_expression (expression) of SNL-induced in dorsal horn associated with allodynia, spinal nerve ligature and dorsal horn
2) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.95
The technique described in the literature for radioguided SNL biopsy for these other cutaneous malignancies is identical to the technique described for malignant melanoma and Merkel cell carcinoma.


Gene_expression (biopsy) of SNL in Merkel cell associated with merkel cell carcinoma and skin cancer
3) Confidence 0.11 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2653072 Disease Relevance 1.28 Pain Relevance 0
SNL-induced Fos expression was restricted to the neuronal population as the ratio of Fos positive NeuN-IR cells to Fos-IR did not vary too much among different groups nor at different time points.
Gene_expression (expression) of SNL-induced in neuronal associated with spinal nerve ligature
4) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.18 Pain Relevance 0.63
SNL enhanced Fos and GFAP expression in the ipsilateral spinal dorsal horn
Gene_expression (expression) of SNL in dorsal horn associated with spinal dorsal horn and spinal nerve ligature
5) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.49 Pain Relevance 0.93
Inhibition of ASO on SNL-induced Fos expression occured right after the nerve injury (at 2 h after SNL).
Gene_expression (expression) of SNL-induced in nerve associated with nervous system injury and spinal nerve ligature
6) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.32 Pain Relevance 1.03
SNL rats in saline and c-fos SO group demonstrated significant ipsilateral allodynia 1 d after the surgery (PWT?
Gene_expression (rats) of SNL associated with allodynia and spinal nerve ligature
7) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.91 Pain Relevance 1.66
C-fos ASO treatment suppressed SNL-induced neuronal and astrocytic activations in different manners
Gene_expression (neuronal) of SNL-induced in neuronal associated with spinal nerve ligature
8) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.40 Pain Relevance 0.85
Thus, SNL itself produced a significant allodynia which was incubated with time; SO treatment did not change the neuropathic pain performance after SNL, while ASO treatment reversed the SNL-induced neuropathic pain with a long-lasting effect.
Gene_expression (produced) of SNL associated with allodynia, spinal nerve ligature and neuropathic pain
9) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.69 Pain Relevance 1.35
Previous studies indicated that SNL produced rapidly appearing (<3 d) and persistent (>3 w) ipsilateral mechanical allodynia shown by decrease of paw withdrawal threshold (PWT) [17], [26].
Gene_expression (produced) of SNL in paw associated with allodynia, spinal nerve ligature and withdrawal
10) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736402 Disease Relevance 0.87 Pain Relevance 1.63
Quantitative real-time PCR analysis of C57BL/6J mice 2-3 weeks after sham or SNL operation also showed no difference of the CK1?
Gene_expression (operation) of SNL
11) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.49
expression in the SNL-operated Cav2.2-/- spinal cord was significantly reduced, which is consistent with the cDNA microarray results.


Gene_expression (expression) of SNL in spinal cord associated with spinal cord
12) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.57 Pain Relevance 0.51
If the SNL injury down regulates some of the gene expression including CK1?
Gene_expression (injury) of SNL associated with injury
13) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.50 Pain Relevance 0.37
Two weeks after SNL, a marked decrease of IB4 binding (both the cell number and the intensity) was observed in ipsilateral L5 DRGs (Figure 5D), which is similar to that shown by a previous study [16].
Gene_expression (weeks) of SNL in IB4
14) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.63 Pain Relevance 0.61
Intriguingly, SNL-induced enhancements of GFAP- and Iba 1-IR were markedly suppressed in Cav2.2-/- mice (Figure 2Cii, 2Ciii, 2D and 2E).
Gene_expression (suppressed) of SNL
15) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.51 Pain Relevance 0.34
mRNA expression in the spinal cord (n = 4 for sham and SNL, data not shown).
Gene_expression (expression) of SNL in spinal cord associated with spinal cord
16) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2804670 Disease Relevance 0.56 Pain Relevance 0.48
Furthermore, CCL2 significantly lowered current threshold only in CCD neurons but not in CCI or SNL neurons.
Neg (not) Gene_expression (neurons) of SNL in neurons associated with eae
17) Confidence 0.04 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20346391 Disease Relevance 0.93 Pain Relevance 0.42
Development of mechanical allodynia in SNL rats
Gene_expression (rats) of SNL associated with allodynia
18) Confidence 0.04 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.36 Pain Relevance 0.37
Separate groups of SNL (n = 4) and sham-operated (n = 4) rats were used for the measurement of levels of endocannabinoids using a previously validated method (Richardson et al., 2007).
Gene_expression (groups) of SNL associated with endocannabinoid
19) Confidence 0.04 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2327204 Disease Relevance 0.08 Pain Relevance 0.65
SNL produced rapidly appearing and persistent mechanical allodynia.
Gene_expression (produced) of SNL associated with allodynia and spinal nerve ligature
20) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942826 Disease Relevance 0.44 Pain Relevance 1.60

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