INT129700

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Context Info
Confidence 0.43
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.86
Pain Relevance 1.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (App) Golgi apparatus (App) plasma membrane (App)
extracellular matrix organization (App) DNA binding (App) cytoplasm (App)
App (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 10 100.00 Very High Very High Very High
Abeta 5 100.00 Very High Very High Very High
diclofenac 2 100.00 Very High Very High Very High
aspirin 2 100.00 Very High Very High Very High
narcan 4 99.66 Very High Very High Very High
Enkephalin 3 90.80 High High
Inflammation 1 89.76 High High
Neurotransmitter 5 5.00 Very Low Very Low Very Low
long-term potentiation 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 93 100.00 Very High Very High Very High
Alzheimer's Dementia 18 100.00 Very High Very High Very High
INFLAMMATION 4 92.00 High High
Neuroblastoma 8 91.84 High High
Targeted Disruption 16 85.60 High High
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Frontotemporal Dementia 5 5.00 Very Low Very Low Very Low
Dementia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we observed neither accumulation of APP-CTFs nor altered A?
Neg (nor) Regulation (altered) of Neg (neither) Positive_regulation (accumulation) of APP
1) Confidence 0.43 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2806870 Disease Relevance 0.17 Pain Relevance 0
PS1 has been shown to be involved in the subcellular trafficking of APP and FAD-linked PS1 variants increase the retention of substrate in compartments where ?
Regulation (trafficking) of Positive_regulation (increase) of APP associated with disease
2) Confidence 0.41 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.66 Pain Relevance 0.08
In the present study, we used fluorescence spectroscopy with thioflavin T and electron microscopy to examine the effects of NSAIDs such as ibuprofen, aspirin, meclofenamic acid sodium salt, diclofenac sodium salt, ketoprofen, flurbiprofen, naproxen, sulindac sulfide and indomethacin on the formation, extension, and destabilization of beta-amyloid fibrils (fA beta) at pH 7.5 at 37 degrees C in vitro.
Spec (examine) Regulation (effects) of Positive_regulation (destabilization) of fA beta associated with aspirin, alzheimer's dementia, cinod and diclofenac
3) Confidence 0.34 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 16125740 Disease Relevance 0.88 Pain Relevance 0.81
This atropine-induced effect was antagonized by simultaneous injections of naloxone (3mg/kg/day) whereas naloxone alone failed to affect Abeta accumulation.
Neg (failed) Regulation (affect) of Positive_regulation (accumulation) of Abeta associated with narcan and abeta
4) Confidence 0.23 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20540990 Disease Relevance 0.15 Pain Relevance 0.53

General Comments

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