INT129703

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Context Info
Confidence 0.37
First Reported 2003
Last Reported 2005
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.63
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 1
cervix 1
ptd (Mus musculus)
Pain Link Frequency Relevance Heat
depression 18 100.00 Very High Very High Very High
guanethidine 2 99.50 Very High Very High Very High
Clonidine 2 99.26 Very High Very High Very High
agonist 22 97.88 Very High Very High Very High
Catecholamine 2 96.76 Very High Very High Very High
Neurotransmitter 4 94.84 High High
cva 2 86.36 High High
antagonist 7 80.64 Quite High
Inflammation 10 64.64 Quite High
cytokine 34 58.64 Quite High
Disease Link Frequency Relevance Heat
Pre-term Labor 40 100.00 Very High Very High Very High
Depression 18 100.00 Very High Very High Very High
Pregnancy Complications 3 96.48 Very High Very High Very High
Premature Birth 9 90.96 High High
Patent Ductus Arteriosus 2 87.40 High High
Hemorrhage 2 86.36 High High
Cerebral Palsy 2 85.16 High High
Bronchopulmonary Dysplasia 1 84.52 Quite High
Alcohol Addiction 1 80.32 Quite High
Nicotine Addiction 1 79.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with clonidine inhibited synaptic transmission and abolished PTD while yohimbine did not affect it.
Negative_regulation (abolished) of PTD associated with depression and clonidine
1) Confidence 0.37 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16126010 Disease Relevance 0.62 Pain Relevance 0.88
Pretreatment with guanethidine (>or=3.5 h) also failed reduce PTD while neurons unresponsive to alpha(2) adrenoceptor agonists routinely exhibited PTD, implying the presence of other inhibitory neurotransmitters sharing a common presynaptic mechanism with alpha(2) agonists.
Neg (failed) Negative_regulation (reduce) of PTD in neurons associated with neurotransmitter, depression, guanethidine and agonist
2) Confidence 0.37 Published 2005 Journal Auton Neurosci Section Abstract Doc Link 16126010 Disease Relevance 0.62 Pain Relevance 0.89
Much of the difficulty in preventing PTL and PTD stems from the likelihood that PTL is probably the final common pathway of a number of pregnancy complications involving the health of the cervix, fetus, fetal membranes, placenta and myometrium [7].
Negative_regulation (preventing) of PTD in cervix associated with pregnancy complications and pre-term labor
3) Confidence 0.01 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305338 Disease Relevance 1.39 Pain Relevance 0.10

General Comments

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