INT129712

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 15
Disease Relevance 7.30
Pain Relevance 1.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TERT) DNA binding (TERT) cytoplasm (TERT)
RNA binding (TERT) chromosome (TERT) nucleolus (TERT)
Anatomy Link Frequency
myoblast 6
somatic cells 2
fibroblasts 2
telomere 2
cytotoxic T cells 2
TERT (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 20 95.48 Very High Very High Very High
Kinase C 239 94.32 High High
Chronic pancreatitis 4 84.28 Quite High
fibrosis 2 82.12 Quite High
cINOD 5 76.80 Quite High
Potency 4 65.36 Quite High
Pain 5 40.40 Quite Low
pruritus 1 39.68 Quite Low
imagery 16 30.20 Quite Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 115 99.60 Very High Very High Very High
Targeted Disruption 36 99.20 Very High Very High Very High
Primary Sclerosing Cholangitis 13 98.08 Very High Very High Very High
Carcinoma 2 91.44 High High
Disease 22 91.28 High High
Adenocarcinoma 5 85.48 High High
Adenoma 2 85.36 High High
Cervical Cancer 5 85.04 High High
Pancreatitis 4 84.28 Quite High
Aging 21 82.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Up-regulated human telomerase reverse transcriptase expression was detectable and increased gradually with cancer development and was primarily observed at the borderline IPMN stage and then in more advanced histopathologies.
Positive_regulation (increased) of Gene_expression (expression) of telomerase reverse transcriptase associated with cancer
1) Confidence 0.70 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.23 Pain Relevance 0.08
Up-regulated human telomerase reverse transcriptase expression was detectable and increased gradually with cancer development and was primarily observed at the borderline IPMN stage and then in more advanced histopathologies.
Positive_regulation (increased) of Gene_expression (expression) of telomerase reverse transcriptase associated with cancer
2) Confidence 0.50 Published 2008 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17960465 Disease Relevance 1.23 Pain Relevance 0.08
The human telomerase reverse transcriptase (hTERT) is nearly universally overexpressed in human cancer, contributes critically to oncogenesis, and is recognized by cytotoxic T cells that lyse tumors.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of telomerase reverse transcriptase in cytotoxic T cells associated with cancer
3) Confidence 0.48 Published 2007 Journal Cancer Res. Section Abstract Doc Link 17974999 Disease Relevance 0.63 Pain Relevance 0
The appreciation from health workers that TCs contribute significantly to a cost reduction has been confirmed in a recent study, in which it was established that the cost-effectiveness of TCs in relation to medical doctors as far as caesarean section is concerned is approximately three times more favourable for TCs than for medical doctors.
Positive_regulation (effectiveness) of Gene_expression (effectiveness) of TCs
4) Confidence 0.44 Published 2007 Journal Hum Resour Health Section Body Doc Link PMC2235883 Disease Relevance 0.15 Pain Relevance 0
While the expression of hTERT is repressed in normal somatic cells (telomerase negative) and is upregulated in immortal cells (telomerase positive), the other components of telomerase holoenzyme are usually expressed ubiquitously in both telomerase positive and telomerase negative cells [7].
Positive_regulation (upregulated) of Gene_expression (expression) of hTERT in somatic cells
5) Confidence 0.28 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.22 Pain Relevance 0
Also, hTERT mRNA expression was upregulated in PBMCs in which PPAR?
Positive_regulation (upregulated) of Gene_expression (expression) of hTERT mRNA
6) Confidence 0.28 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.15 Pain Relevance 0.41
silencing on hTERT gene transcription. hTERT mRNA expression was found to increase in PPAR?
Positive_regulation (increase) of Gene_expression (expression) of hTERT mRNA
7) Confidence 0.20 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.19 Pain Relevance 0.20
The Oct4-overexpressed ATSC cells showed prominent effects on upregulation of a variety of proliferation-associated genes, including RUNX3, CDK2 and CDK4, and telomere reverse transcriptase (TERT; Fig. 1D).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of TERT in telomere
8) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.18 Pain Relevance 0.03
may contribute to carcinogenesis through the upregulation of hTERT expression.
Positive_regulation (upregulation) of Gene_expression (expression) of hTERT
9) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.32 Pain Relevance 0.08
The exposure of PBMCs to PMA resulted in a gradual increase in mRNA levels of hTERT, c-myc and PPAR?
Positive_regulation (increase) of Gene_expression (levels) of hTERT
10) Confidence 0.19 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1351175 Disease Relevance 0.05 Pain Relevance 0.40
The cells were isolated by the outgrowth method and were immortalized by transfection with SV40 large T antigen and human telomerase (hTERT).
Positive_regulation (transfection) of Gene_expression (transfection) of telomerase
11) Confidence 0.02 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127427 Disease Relevance 1.02 Pain Relevance 0.16
Here we describe the generation of immortalized myoblast cell lines derived from healthy (DMPK CTG5) and DM1 patient (DMPK CTG1000) fibroblasts by constitutive overexpression of human telomerase reverse transcriptase (hTERT) and inducible overexpression of the Myoblast determination factor (MYOD).
Positive_regulation (overexpression) of Gene_expression (overexpression) of telomerase reverse transcriptase in myoblast
12) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Abstract Doc Link PMC2874217 Disease Relevance 0.50 Pain Relevance 0
Wildtype (WT) DMPK CTG5 and DM1 patient (DMPK CTG1000) fibroblast cells were immortalized following introduction of constitutively overexpressed hTERT, which has previously been shown to allow human fibroblasts to proliferate for at least 36 population doublings [43].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of hTERT in fibroblasts
13) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Body Doc Link PMC2874217 Disease Relevance 0.40 Pain Relevance 0
Here we describe the generation of immortalized myoblast cell lines derived from healthy (DMPK CTG5) and DM1 patient (DMPK CTG1000) fibroblasts by constitutive overexpression of human telomerase reverse transcriptase (hTERT) and inducible overexpression of the Myoblast determination factor (MYOD).
Positive_regulation (overexpression) of Gene_expression (overexpression) of telomerase reverse transcriptase in myoblast
14) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Abstract Doc Link PMC2874217 Disease Relevance 0.51 Pain Relevance 0
Here we describe the generation of immortalized myoblast cell lines derived from healthy (DMPK CTG5) and DM1 patient (DMPK CTG1000) fibroblasts by constitutive overexpression of human telomerase reverse transcriptase (hTERT) and inducible overexpression of the Myoblast determination factor (MYOD).
Positive_regulation (overexpression) of Gene_expression (overexpression) of hTERT in myoblast
15) Confidence 0.01 Published 2010 Journal Current Chemical Genomics Section Abstract Doc Link PMC2874217 Disease Relevance 0.51 Pain Relevance 0

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