INT129722

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 6.75
Pain Relevance 2.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFRSF10D)
TNFRSF10D (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 99.74 Very High Very High Very High
fibrosis 10 98.52 Very High Very High Very High
Chronic pancreatitis 26 98.28 Very High Very High Very High
rheumatoid arthritis 65 91.92 High High
agonist 2 75.88 Quite High
Inflammation 45 73.52 Quite High
Arthritis 64 72.32 Quite High
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 61 100.00 Very High Very High Very High
Hypoglycemia 4 98.86 Very High Very High Very High
Fibrosis 12 98.52 Very High Very High Very High
Pancreatitis 26 98.28 Very High Very High Very High
Death 19 92.28 High High
Rheumatoid Arthritis 65 91.92 High High
Necrosis 7 82.72 Quite High
Cancer 14 82.36 Quite High
Keloid Scars 2 76.56 Quite High
INFLAMMATION 19 73.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In CM, TGFbeta/IFNgamma/TRAIL induced TRAIL-R4 surface expression.
Gene_expression (expression) of TRAIL-R4
1) Confidence 0.58 Published 2006 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 17867593 Disease Relevance 1.44 Pain Relevance 0.71
We treated CM with cytokines, determined TRAIL-R expression by flow cytometry, graded degree of fibrosis in CP specimens, microdissected epithelial compartments, performed real time PCRs for NFkappaB subunits transcripts, and immunohistochemistry for IKK-gamma, IkappaB-alpha, RelA, survivin, and cIAP1.
Spec (determined) Gene_expression (expression) of TRAIL-R associated with fibrosis, chronic pancreatitis and cytokine
2) Confidence 0.58 Published 2006 Journal Verh Dtsch Ges Pathol Section Abstract Doc Link 17867593 Disease Relevance 1.36 Pain Relevance 0.63
Of note, decoy receptor-2 (DcR2) a TRAIL-R and a target for p53 siRNA [131], but only in combination with Ad5hTRAIL, eliminated the TRAIL-induced resistance to apoptosis in these cells to a more significant extent than when the cells were transfected with Ad5hTRAIL alone.
Gene_expression (transfected) of DcR2 associated with apoptosis
3) Confidence 0.07 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.17 Pain Relevance 0.34
Here, we demonstrate that in insulinoma cells CM, TGFbeta/IFNgamma/TRAIL in combination induced TRAIL-R4 surface expression.
Gene_expression (expression) of TRAIL-R4 associated with hypoglycemia
4) Confidence 0.06 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127431 Disease Relevance 1.39 Pain Relevance 0.49
Here, we demonstrate that in insulinoma cells CM, TGFbeta/IFNgamma/TRAIL in combination induced TRAIL-R4 surface expression.
Gene_expression (expression) of TRAIL-R4 associated with hypoglycemia
5) Confidence 0.05 Published 2005 Journal Lab. Invest. Section Abstract Doc Link 16127431 Disease Relevance 1.39 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox