INT129737

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 16
Disease Relevance 2.39
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Casr) signal transducer activity (Casr)
Anatomy Link Frequency
D cells 2
parietal cells 2
G cells 2
Casr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 105 99.96 Very High Very High Very High
Somatostatin 210 97.92 Very High Very High Very High
Calcitonin gene-related peptide 195 92.76 High High
peptic ulcer disease 15 68.88 Quite High
abdominal pain 1 66.56 Quite High
antagonist 30 56.68 Quite High
nud 30 21.36 Low Low
dorsal root ganglion 30 5.00 Very Low Very Low Very Low
Cholecystokinin 30 5.00 Very Low Very Low Very Low
ASIC 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 1 99.78 Very High Very High Very High
Kidney Stones 7 99.24 Very High Very High Very High
Hypocalcemia 4 98.72 Very High Very High Very High
Gastroesophageal Reflux Disease 15 98.68 Very High Very High Very High
Targeted Disruption 30 80.16 Quite High
Hypomagnesemia 1 72.96 Quite High
Acid Reflux 15 69.52 Quite High
Disease 15 68.88 Quite High
Ulcers 30 68.56 Quite High
Convulsion 2 67.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro studies on CaSR-transfected HEK 293 cell line by Quinn et al. [37] confirmed an extracellular pH-dependent activation of CaSR, as manifest by increased intracellular Ca2+ in the presence of extracellular Ca2+ and Mg2+.
Positive_regulation (activation) of CaSR
1) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.07 Pain Relevance 0.03
In light of prior known actions of CaSR activation increasing gastrin and acid secretion, the net effect of CaSR ligands may depend on its relative expression in each cell type, whether stimulatory G cells or inhibitory D cells, and whether the endocrine cells are of the closed or open type.
Positive_regulation (activation) of CaSR in D cells
2) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.16
The stimulation of CaSR in human cultured antral G cells releases gastrin.
Positive_regulation (stimulation) of CaSR in G cells
3) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.08
Stimulation of CaSR in vivo with the allosteric agonist cinacalcet supports the above findings, because significant increases in serum gastrin levels and basal gastric acid secretion have been reported [33•].
Positive_regulation (Stimulation) of CaSR associated with agonist
4) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.12
From pH 7.5 to 9.0, CaSR activation was enhanced, shifting the threshold concentration and effective concentration for 50% curve for Ca2+ to the left, whereas the opposite was observed with pH 5.5 to 7.5.
Positive_regulation (activation) of CaSR
5) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.06 Pain Relevance 0.04
Using the potent stimulant Gd3+, CaSR activation can also occur without histamine [26].
Positive_regulation (activation) of CaSR
6) Confidence 0.52 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.05 Pain Relevance 0.08
In light of prior known actions of CaSR activation increasing gastrin and acid secretion, the net effect of CaSR ligands may depend on its relative expression in each cell type, whether stimulatory G cells or inhibitory D cells, and whether the endocrine cells are of the closed or open type.
Positive_regulation (activation) of CaSR in D cells
7) Confidence 0.38 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.29 Pain Relevance 0.16
For these ligands, acidic pH enhanced activation of CaSR.
Positive_regulation (activation) of CaSR
8) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.17 Pain Relevance 0.14
CaSR activation may be modified by extracellular pH because the acid–base balance of ligands and receptor binding sites is pH-dependent [37].
Positive_regulation (activation) of CaSR
9) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.09 Pain Relevance 0
Interestingly, activity of the CaSR was markedly increased below pH 5.5 independent of agonist stimulation.
Positive_regulation (increased) of CaSR associated with agonist
10) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.05 Pain Relevance 0.05
Because the CaSR is present on the basolateral surface of G cells and parietal cells, one consideration is that exposure to the alkaline environments (eg, the alkaline tide after gastric secretion) would further enhance CaSR activation.
Positive_regulation (activation) of CaSR in parietal cells
11) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.09
In accordance with these findings, when exposed to a constant extracellular calcium concentration, CaSR activation had a linear correlation with extracellular pH, demonstrating one manner in which it may serve as a pH sensor.
Positive_regulation (activation) of CaSR
12) Confidence 0.35 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.08
The CaSR is activated by polyvalent cations and polycationic molecules as described above.
Positive_regulation (activated) of CaSR
13) Confidence 0.31 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.10 Pain Relevance 0
CaSR present on parietal cells in intact rat gastric glands [26] and human gastric tissue [31] is activated with the divalent cations Ca2+ and Mg2+, which enhances histamine-induced, H+/K+ ATPase-mediated acid secretion.
Positive_regulation (activated) of CaSR in parietal cells
14) Confidence 0.31 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.06 Pain Relevance 0.14
Autosomal dominant hypocalcaemia with hypercalciuria (ADHH) is an intriguing syndrome, in which activating mutations of the calcium sensing receptor (CaSR) have recently been recognised.
Positive_regulation (activating) of CaSR associated with hypocalcemia, syndrome and kidney stones
15) Confidence 0.16 Published 2005 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 16128246 Disease Relevance 1.16 Pain Relevance 0.07
Because the CaSR is present on the basolateral surface of G cells and parietal cells, one consideration is that exposure to the alkaline environments (eg, the alkaline tide after gastric secretion) would further enhance CaSR activation.
Positive_regulation (activation) of CaSR in G cells
16) Confidence 0.12 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0 Pain Relevance 0.09

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