INT129746

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Context Info
Confidence 0.18
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 2.15
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Tfrc) peptidase activity (Tfrc) mitochondrion (Tfrc)
extracellular region (Tfrc) cytoplasmic membrane-bounded vesicle (Tfrc) plasma membrane (Tfrc)
Anatomy Link Frequency
T cell 6
astrocyte 4
fibroblast 2
Tfrc (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 15 100.00 Very High Very High Very High
cINOD 45 99.10 Very High Very High Very High
fluoxetine 4 98.36 Very High Very High Very High
aspirin 123 97.60 Very High Very High Very High
Inflammatory response 2 96.12 Very High Very High Very High
Inflammation 26 88.00 High High
antidepressant 3 86.24 High High
depression 1 77.88 Quite High
Pyramidal cell 12 13.08 Low Low
Intracerebroventricular 32 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 4 100.00 Very High Very High Very High
INFLAMMATION 37 95.94 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 78.48 Quite High
Depression 1 77.88 Quite High
Brain Injury 6 77.56 Quite High
Disease 41 61.36 Quite High
Disorder Of Lipid Metabolism 8 50.00 Quite Low
Viral Meningitis 4 48.08 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 47.56 Quite Low
Motor Neuron Diseases 10 46.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Primary astrocyte cultures from these same TR APOE mice show LPS-mediated innate immune activation that is greatest with TR APOE2, less with TR APOE3, and least with TR APOE4 that correlates with NF-?
Positive_regulation (activation) of Gene_expression (cultures) of TR in astrocyte
1) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.35 Pain Relevance 0.08
Primary astrocyte cultures from these same TR APOE mice show LPS-mediated innate immune activation that is greatest with TR APOE2, less with TR APOE3, and least with TR APOE4 that correlates with NF-?
Positive_regulation (same) of Gene_expression (these) of TR in astrocyte
2) Confidence 0.18 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1584222 Disease Relevance 0.35 Pain Relevance 0.08
In order to study a role of some mediators of pro-inflammatory response in this process, presently, we investigated the effect of lipopolysaccharide (LPS) on imipramine- or fluoxetine-induced inhibition of GR-mediated gene transcription in fibroblast cells, stably transfected with mouse mammary tumor virus promoter (LMCAT cells).
Positive_regulation (transfected) of Gene_expression (transfected) of mammary tumor virus promoter in fibroblast associated with inflammatory response, cancer and fluoxetine
3) Confidence 0.15 Published 2005 Journal Pharmacol Rep Section Abstract Doc Link 16129923 Disease Relevance 0.50 Pain Relevance 0.61
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Positive_regulation (activation) of Gene_expression (expression) of CD71 in T cell associated with cinod and cytokine
4) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 0.99
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Positive_regulation (as) of Gene_expression (expression) of CD71 in T cell associated with cinod and cytokine
5) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 1.00
NSAIDs were shown to inhibit T cell proliferation, expression of activation-related molecules such as CD25 and CD71, and the production of cytokines such as IL-2, IFN-?
Positive_regulation (as) of Gene_expression (expression) of CD71 in T cell associated with cinod and cytokine
6) Confidence 0.08 Published 2010 Journal Immune Network Section Body Doc Link PMC2902675 Disease Relevance 0.32 Pain Relevance 0.99

General Comments

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