INT12975

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Context Info
Confidence 0.60
First Reported 1983
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 21
Total Number 23
Disease Relevance 13.62
Pain Relevance 8.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Link Frequency
platelet 18
plasma 1
vasculature 1
monocyte 1
brain 1
PLEK (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 15 100.00 Very High Very High Very High
antidepressant 7 100.00 Very High Very High Very High
fluoxetine 3 100.00 Very High Very High Very High
noradrenaline 1 100.00 Very High Very High Very High
chemokine 1 100.00 Very High Very High Very High
Desipramine 1 100.00 Very High Very High Very High
substance P 20 99.96 Very High Very High Very High
5HT 6 99.96 Very High Very High Very High
Catecholamine 3 99.44 Very High Very High Very High
aspirin 65 99.26 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 52 100.00 Very High Very High Very High
Myocardial Infarction 40 99.44 Very High Very High Very High
Adhesions 9 99.28 Very High Very High Very High
Depression 5 98.96 Very High Very High Very High
Headache 33 98.32 Very High Very High Very High
Schizophrenia 9 98.28 Very High Very High Very High
Coronary Artery Disease 25 98.14 Very High Very High Very High
Heparin-induced Thrombocytopenia 6 97.88 Very High Very High Very High
Osteoarthritis 3 97.60 Very High Very High Very High
Transient Ischemic Attack 10 95.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of canine platelet function II.
Regulation (Regulation) of platelet in platelet
1) Confidence 0.60 Published 1983 Journal Am. J. Physiol. Section Title Doc Link 6869571 Disease Relevance 0 Pain Relevance 0.37
The past several years have seen the introduction of many platelet GPIIb/IIIa blockers into the clinical arena targeting the unique platelet GPIIb/IIIa receptor for the adhesive proteins, fibrinogen and von Willebrand Factor.
Regulation (targeting) of platelet in platelet
2) Confidence 0.60 Published 2000 Journal Expert Opin Investig Drugs Section Abstract Doc Link 11060829 Disease Relevance 0.94 Pain Relevance 0.16
The introduction of new platelet glycoprotein (GP) IIb/IIIa receptor inhibitors has the potential to revolutionize the treatment of certain patients with unstable angina and non-ST-segment elevation myocardial infarction (MI).
Regulation (introduction) of platelet in platelet associated with angina and myocardial infarction
3) Confidence 0.44 Published 2000 Journal J Emerg Med Section Abstract Doc Link 11050379 Disease Relevance 0.47 Pain Relevance 0.20
In the PURSUIT trial, 9,461 patients received a platelet glycoprotein IIb/IIIa inhibitor, eptifibatide or placebo for 72 h.
Regulation (received) of platelet in platelet
4) Confidence 0.44 Published 2002 Journal J. Am. Coll. Cardiol. Section Body Doc Link 12084589 Disease Relevance 0.07 Pain Relevance 0
Finally, a number of other mediators are involved in the cerebral brain response to immune challenge including, among others, chemokines, macrophage migrating inhibitory factor, platelet activating factor, superoxide radicals and carbon monoxide.


Regulation (response) of platelet in brain associated with chemokine
5) Confidence 0.44 Published 2005 Journal Crit Care Section Body Doc Link PMC1065096 Disease Relevance 0.39 Pain Relevance 0.43
In the AMI group, both the plasma and platelet PAI-1 concentrations were greater on day 1, but the plasma PAI-1 rapidly decreased by day 5 and remained low on day 28 compared with day 1.
Regulation (greater) of platelet in plasma associated with myocardial infarction
6) Confidence 0.44 Published 2000 Journal Jpn. Circ. J. Section Abstract Doc Link 10952148 Disease Relevance 1.66 Pain Relevance 0.13
Clinical trials have reported the beneficial effects of platelet glycoprotein (GP) IIb/IIIa receptor antagonists and low-molecular-weight heparins in patients presenting with unstable angina or non-ST elevation myocardial infarction.
Regulation (effects) of platelet in platelet associated with angina, antagonist and myocardial infarction
7) Confidence 0.44 Published 2000 Journal J Invasive Cardiol Section Abstract Doc Link 10731290 Disease Relevance 0.52 Pain Relevance 0.22
The effects of treatment with serotonin (5-HT) reuptake inhibitors on platelet 5-HT2 receptors, 5-HT reuptake sites an 5-HT uptake were studied in a double-blind trial comparing two selective serotonin reuptake inhibitors (SSRI), paroxetine, and fluoxetine, for the treatment of major depression.
Regulation (effects) of platelet in platelet associated with depression, ssri, serotonin and fluoxetine
8) Confidence 0.44 Published 1997 Journal Biol. Psychiatry Section Abstract Doc Link 9018388 Disease Relevance 0.25 Pain Relevance 0.43
In controls, platelet 5HT levels remained stable, whereas 5HIAA levels and MAO activity were higher in the luteal than in the follicular phase, suggesting an increased catabolism of 5HT which occurs physiologically just before menses.
Regulation (controls) of platelet in platelet associated with 5ht
9) Confidence 0.44 Published 1996 Journal Cephalalgia Section Abstract Doc Link 8902252 Disease Relevance 0.48 Pain Relevance 0.76
This study compares the effects of chronic antidepressant treatment with a serotonin reuptake inhibitor (fluoxetine) versus a noradrenaline reuptake inhibitor (desipramine) on the binding parameters of the platelet imidazoline binding site (subtype I1) and of the platelet alpha 2-adrenoceptor in depressed patients.
Regulation (effects) of platelet in platelet associated with desipramine, antidepressant, noradrenaline, serotonin and fluoxetine
10) Confidence 0.44 Published 1996 Journal J Psychiatr Res Section Abstract Doc Link 8884656 Disease Relevance 0.10 Pain Relevance 0.53
In the present study we considered some of the parameters previously examined in the literature, such as, age, sex, response to initial steroid treatment and/or IVIG therapy, time between diagnosis and surgery, and positivity for anti-platelet antibody, platelet associated antibody, and ANA.
Regulation (response) of platelet in platelet
11) Confidence 0.44 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782196 Disease Relevance 0.63 Pain Relevance 0
Also in patients who were taking aspirin and had both osteoarthritis and ischemic heart disease, celecoxib, unlike ibuprofen, did not influence aspirin's action to irreversibly inactivate platelet COX-1.19)

Potential beneficial effects of celecoxib on the vasculature

Regulation (effects) of platelet in vasculature associated with aspirin, coronary artery disease and osteoarthritis
12) Confidence 0.44 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2910288 Disease Relevance 0.58 Pain Relevance 0.37
This paper reviews how polymorphisms in the platelet glycoprotein receptors affect platelet function, susceptibility to atherothrombosis and its major complications including myocardial infarction, stroke, and complications following percutaneous coronary interventions, and individual variability of drug response.
Regulation (affect) of platelet in platelet associated with stroke and myocardial infarction
13) Confidence 0.44 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14614592 Disease Relevance 1.28 Pain Relevance 0.08
This is assessed using the human whole blood assays which evaluate the effects of drugs on platelet COX-1 and monocyte COX-2 activities (Patrono et al 1980; Patrignani et al 1994).
Regulation (effects) of platelet in monocyte
14) Confidence 0.26 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621416 Disease Relevance 0.20 Pain Relevance 0.18
Heparin-induced thrombocytopenia (HIT) is another well known complication of heparin, its incidence being approximately 0.8%, with LMWH, about 3-fold lower than with UFH.67,68 HIT is caused by heparin-dependent antibodies (usually immunoglobulin G) binding a confirmationally modified epitope on platelet factor 4 (PF4), its modified structure being subsequently recognized as a foreign protein by the immunocompetent cells of the patients.
Regulation (epitope) of platelet in platelet associated with heparin-induced thrombocytopenia
15) Confidence 0.26 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2762431 Disease Relevance 1.18 Pain Relevance 0.12
The present study was undertaken to investigate alterations in platelet 5-HT2A receptors using 3H ketanserin as a ligand.
Spec (investigate) Regulation (alterations) of platelet in platelet
16) Confidence 0.26 Published 2003 Journal Headache Section Body Doc Link 12558763 Disease Relevance 0.08 Pain Relevance 0
The present results indicate that alteration of platelet serotonin transporters is associated with schizophrenia.
Regulation (alteration) of platelet in platelet associated with serotonin and schizophrenia
17) Confidence 0.26 Published 2002 Journal Neurochem. Int. Section Abstract Doc Link 12106771 Disease Relevance 0.52 Pain Relevance 0.40
Species differences in alpha 2-adrenergic regulation of platelet adenylate cyclase.
Regulation (regulation) of platelet in platelet
18) Confidence 0.26 Published 1991 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Title Doc Link 1658886 Disease Relevance 0 Pain Relevance 0.20
We have determined its effect on platelet cyclooxygenase in man.
Spec (determined) Regulation (effect) of platelet in platelet
19) Confidence 0.26 Published 1996 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 8866627 Disease Relevance 0.09 Pain Relevance 0.24
The concentrations of platelet SP in the migrainous patients and in the TH patients were significantly higher than those in the controls.
Regulation (concentrations) of platelet in platelet associated with headache and substance p
20) Confidence 0.26 Published 1993 Journal Headache Section Abstract Doc Link 7507472 Disease Relevance 1.01 Pain Relevance 1.29

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